LSM6 - LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated Gene

Homo sapiens

Also known as YDR378C

Gene ID: 11157 | Gene type: protein coding

About LSM6

Cytogenetic location: 4q31.22 Genomic coordinates (GRCh38): 4:146,175,718-146,191,535 (from NCBI)

This gene has 8 transcripts (splice variants), 225 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 5.0), lymph node (RPKM 4.2) and 25 other tissues.

Summary

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004]

LSM6 Products(1)

mRNA	Protein	Name
NM_007080.3	NP_009011.1	U6 snRNA-associated Sm-like protein LSm6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15231747	GOA
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	12515382	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within mRNA catabolic process	IDA IDA: Inferred from direct assay	12515382	GOA
involved in mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	28781166	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Lsm2-8 complex	IDA IDA: Inferred from direct assay	10523320	GOA
part of U2-type precatalytic spliceosome	IDA IDA: Inferred from direct assay	28781166	GOA
part of U4/U6 x U5 tri-snRNP complex	IDA IDA: Inferred from direct assay	26912367	GOA
part of U4/U6 x U5 tri-snRNP complex	IPI IPI: Inferred from physical interaction	30975767	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	12515382	GOA
located in nucleus	IDA IDA: Inferred from direct assay	26912367	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LSM6 Protein Structure

LSM

0
80 a.a.

Protein Preferred Names

Protein Names

U6 snRNA-associated Sm-like protein LSm6

LSM6 U6 small nuclear RNA and mRNA degradation associated

LSM6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LSM6	P62312	PATL1	Homo sapiens	Q86TB9	Anti Tag CoIP	33961781
Intra	LSM6	P62312	PATL1	Homo sapiens	Q86TB9	Validated Y2H	32296183
Intra	LSM6	P62312	SNRPD2	Homo sapiens	P62316	Anti Tag CoIP	33961781
Intra	LSM6	P62312	SNRPD2	Homo sapiens	P62316	Anti Tag CoIP	28514442
Intra	LSM6	P62312	SNRPD2	Homo sapiens	P62316	Y2H	15231747
Intra	LSM6	P62312	LSM2	Homo sapiens	Q9Y333	Anti Tag CoIP	33961781
Intra	LSM6	P62312	LSM2	Homo sapiens	Q9Y333	Anti Tag CoIP	28514442
Intra	LSM6	P62312	LSM2	Homo sapiens	Q9Y333	Validated Y2H	32296183
Intra	LSM6	P62312	LSM1	Homo sapiens	O15116	Anti Tag CoIP	33961781
Intra	LSM6	P62312	LSM1	Homo sapiens	O15116	Anti Tag CoIP	28514442
Intra	LSM6	P62312	LSM1	Homo sapiens	O15116	Y2H	15231747
Intra	LSM6	P62312	LSM8	Homo sapiens	O95777	Anti Tag CoIP	33961781
Intra	LSM6	P62312	LSM8	Homo sapiens	O95777	Y2H	15231747
Intra	LSM6	P62312	LSM8	Homo sapiens	O95777	Anti Tag CoIP	28514442
Intra	LSM6	P62312	LSM3	Homo sapiens	P62310	Anti Tag CoIP	28514442
Intra	LSM6	P62312	LSM3	Homo sapiens	P62310	Y2H Array	25416956
Intra	LSM6	P62312	LSM3	Homo sapiens	P62310	Y2H Array	32296183
Intra	LSM6	P62312	LSM3	Homo sapiens	P62310	Y2H	15231747
Intra	LSM6	P62312	LSM3	Homo sapiens	P62310	Y2H Prey Pooling	32296183
Intra	LSM6	P62312	LSM3	Homo sapiens	P62310	Anti Tag CoIP	33961781
Intra	LSM6	P62312	LSM7	Homo sapiens	Q9UK45	Anti Tag CoIP	33961781
Intra	LSM6	P62312	LSM7	Homo sapiens	Q9UK45	Anti Tag CoIP	28514442
Intra	LSM6	P62312	LSM7	Homo sapiens	Q9UK45	Y2H	15231747
Intra	LSM6	P62312	SNRPF	Homo sapiens	P62306	Y2H	22365833
Intra	LSM6	P62312	LSM5	Homo sapiens	Q9Y4Y9	Y2H Prey Pooling	25416956
Intra	LSM6	P62312	LSM5	Homo sapiens	Q9Y4Y9	Validated Y2H	25416956
Intra	LSM6	P62312	LSM5	Homo sapiens	Q9Y4Y9	Anti Tag CoIP	33961781
Intra	LSM6	P62312	LSM5	Homo sapiens	Q9Y4Y9	Y2H Prey Pooling	32296183
Intra	LSM6	P62312	LSM5	Homo sapiens	Q9Y4Y9	Validated Y2H	32296183
Intra	LSM6	P62312	LSM5	Homo sapiens	Q9Y4Y9	Y2H	15231747
Intra	LSM6	P62312	LSM5	Homo sapiens	Q9Y4Y9	Y2H Array	32296183
Intra	LSM6	P62312	LSM5	Homo sapiens	Q9Y4Y9	Y2H	22365833
Intra	LSM6	P62312	CLNS1A	Homo sapiens	P54105	Y2H Prey Pooling	32296183
Intra	LSM6	P62312	CLNS1A	Homo sapiens	P54105	Y2H	22365833
Intra	LSM6	P62312	CLNS1A	Homo sapiens	P54105	Anti Tag CoIP	33961781
Intra	LSM6	P62312	CLNS1A	Homo sapiens	P54105	Y2H Array	25416956
Intra	LSM6	P62312	CLNS1A	Homo sapiens	P54105	Y2H Array	32296183
Intra	LSM6	P62312	CLNS1A	Homo sapiens	P54105	Anti Tag CoIP	28514442
Intra	LSM6	P62312	SDCBP	Homo sapiens	O00560	Y2H Array	32296183
Intra	LSM6	P62312	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	25416956
Intra	LSM6	P62312	SDCBP	Homo sapiens	O00560	Validated Y2H	25416956
Intra	LSM6	P62312	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	32296183
Intra	LSM6	P62312	SDCBP	Homo sapiens	O00560	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Spinal Muscular Atrophy

Sma	5q Sma
Proximal Sma	Sma-Associated Sma
Spinal Amyotrophies	Spinal Amyotrophy
Spinal Muscle Degeneration	Spinal Muscle Wasting
Muscular Atrophy Spinal	Atrophy, Muscular, Spinal
Hereditary Motor Neuronopathy	Progressive Muscular Atrophy
Sma - [Spinal Muscular Atrophy]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07861	LSM6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	LSM6	VGNC	VGNC:63324
Rattus norvegicus	LSM6	RGD	RGD:1561937
Canis familiaris	LSM6	VGNC	VGNC:42845
Macaca mulatta	LSM6	VGNC	VGNC:107181
Mus musculus	LSM6	MGD	MGI:1925901
Bos taurus	LSM6	VGNC	VGNC:31058

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