PDPK1 - 3-phosphoinositide dependent protein kinase 1 Gene

Homo sapiens

Also known as PDK1; PDPK2; PDPK2P; PRO0461

Gene ID: 5170 | Gene type: protein coding

About PDPK1

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:2,538,021-2,603,188 (from NCBI)

This gene has 17 transcripts (splice variants), 237 orthologues and 5 paralogues. Ubiquitous expression in brain (RPKM 5.6), testis (RPKM 5.3) and 25 other tissues.

Summary

Enables 3-phosphoinositide-dependent protein kinase activity; Phospholipase activator activity; and Phospholipase binding activity. Involved in several processes, including cell surface receptor signaling pathway; regulation of protein kinase activity; and regulation of signal transduction. Acts upstream of or within intracellular signal transduction. Located in cell projection; cytosol; and plasma membrane. Implicated in prostate Cancer. Biomarker of lung non-small cell carcinoma. [provided by Alliance of Genome Resources, Apr 2022]

PDPK1 Products(3)

mRNA	Protein	Name
NM_001261816.2	NP_001248745.1	3-phosphoinositide-dependent protein kinase 1 isoform 3
NM_002613.5	NP_002604.1	3-phosphoinositide-dependent protein kinase 1 isoform 1
NM_031268.6	NP_112558.2	3-phosphoinositide-dependent protein kinase 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 3-phosphoinositide-dependent protein kinase activity	IDA IDA: Inferred from direct assay	9368760	GOA
enables phospholipase activator activity	IMP IMP: Inferred from mutant phenotype	22454520	GOA
enables phospholipase binding	IPI IPI: Inferred from physical interaction	22454520	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11438723	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	9368760	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in activation of protein kinase B activity	IDA IDA: Inferred from direct assay	9368760	GOA
involved in calcium-mediated signaling	IMP IMP: Inferred from mutant phenotype	22454520	GOA
involved in cell migration	IMP IMP: Inferred from mutant phenotype	22454520	GOA
involved in cellular response to epidermal growth factor stimulus	IMP IMP: Inferred from mutant phenotype	22454520	GOA
involved in cellular response to insulin stimulus	IMP IMP: Inferred from mutant phenotype	10567711	GOA
involved in epidermal growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	22454520	GOA
involved in extrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	16207722	GOA
acts upstream of or within intracellular signal transduction	IDA IDA: Inferred from direct assay	14749367	GOA
involved in negative regulation of endothelial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	26235810	GOA
involved in negative regulation of protein kinase activity	IDA IDA: Inferred from direct assay	9373175	GOA
involved in negative regulation of transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	17327236	GOA
involved in peptidyl-threonine phosphorylation	IDA IDA: Inferred from direct assay	9368760	GOA
involved in positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	23802567	GOA
involved in positive regulation of blood vessel endothelial cell migration	IMP IMP: Inferred from mutant phenotype	23802567	GOA
involved in positive regulation of phospholipase activity	IMP IMP: Inferred from mutant phenotype	22454520	GOA
involved in positive regulation of protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	10567711	GOA
involved in positive regulation of release of sequestered calcium ion into cytosol	IDA IDA: Inferred from direct assay	22454520	GOA
involved in positive regulation of sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	26235810	GOA
involved in positive regulation of vascular endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	23802567	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	14585963	GOA
involved in regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	16207722	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell projection	IDA IDA: Inferred from direct assay	22454520	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	9637919	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	9637919	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDPK1 Protein Structure

Pkinase

PH_3

0
100
200
300
400
500
556 a.a.

Protein Preferred Names

Protein Names

3-phosphoinositide-dependent protein kinase 1

3-phosphoinositide-dependent protein kinase 2 pseudogene

PDPK1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PDPK1	O15530	PPP2R2B	Homo sapiens	Q00005	Anti Bait CoIP	21075311
Intra	PDPK1	O15530	PPP2R2B	Homo sapiens	Q00005	Anti Tag CoIP	21075311
Intra	PDPK1	O15530	TBL2	Homo sapiens	Q9Y4P3	Anti Tag CoIP	33961781
Intra	PDPK1	O15530	TBL2	Homo sapiens	Q9Y4P3	Anti Tag CoIP	20562859
Intra	PDPK1	O15530	AKT1	Homo sapiens	P31749	Protein Kinase Assay	26256536
Intra	PDPK1	O15530	AKT1	Homo sapiens	P31749	Anti Bait CoIP	21775285
Intra	PDPK1	O15530	AKT1	Homo sapiens	P31749	Beta Lactamase	11438723
Intra	PDPK1	O15530	ULK1	Homo sapiens	O75385	CoIP	26593251

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Endometrial Cancer

Endometrial Carcinoma	Endometrial Neoplasm
Malignant Neoplasm Of Endometrium	Endometrioid Carcinoma
Endometrial Neoplasms	Carcinoma, Endometrioid
Endometrial Cancer, Familial	Endometrial Carcinoma, Somatic
Endometrial Cancer, Susceptibility To	Endometrial Ca
Malignant Endometrial Neoplasm	Neoplasm Of Endometrium
Primary Malignant Neoplasm Of Endometrium	Tumor Of Endometrium
Carcinoma Of The Endometrium	Endometrioid Carcinoma Of Female Reproductive System
ENDMC	Carcinoma Endometrioid
Endometrial Cancers	Cancer, Endometrial
Uterine Corpus Cancer

Cowden Syndrome 6

CWS6	Cowden Syndrome, Type 6

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Intestinal Obstruction

Inspissated Milk Syndrome

Milk Curd Syndrome

Small Cell Carcinoma

Small Cell Carcinoma, Intermediate Cell	Intermediate Cell Small Cell Carcinoma
Small Cell Carcinoma - Intermediate Cell	Small Cell Carcinoma Of Lung
Carcinoma, Small Cell

Esophageal Adenosquamous Carcinoma

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12063	PHT-427		98.09%	Unkown
HY-108263B	(R)-3-Hydroxy Midostaurin	Inhibitor	/	Unkown
HY-RS10287	PDPK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PDPK1	MGD	MGI:1338068
Canis familiaris	PDPK1	VGNC	VGNC:54055
Rattus norvegicus	PDPK1	RGD	RGD:620307
Felis catus	PDPK1	VGNC	VGNC:107808
Others	PDPK1	NCBI

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