INPP5K - inositol polyphosphate-5-phosphatase K Gene

Homo sapiens

Also known as PPS; SKIP; MDCCAID

Gene ID: 51763 | Gene type: protein coding

About INPP5K

Cytogenetic location: 17p13.3 Genomic coordinates (GRCh38): 17:1,494,577-1,516,612 (from NCBI)

This gene has 20 transcripts (splice variants), 287 orthologues, 13 paralogues and is associated with 3 phenotypes. Ubiquitous expression in fat (RPKM 17.9), lung (RPKM 14.5) and 25 other tissues.

Summary

This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin Cytoskeleton. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]

INPP5K Products(3)

mRNA	Protein	Name
NM_001135642.2	NP_001129114.1	inositol polyphosphate 5-phosphatase K isoform 2
NM_016532.4	NP_057616.2	inositol polyphosphate 5-phosphatase K isoform 1
NM_130766.3	NP_570122.1	inositol polyphosphate 5-phosphatase K isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables inositol bisphosphate phosphatase activity	IDA IDA: Inferred from direct assay	10753883	GOA
enables inositol trisphosphate phosphatase activity	IDA IDA: Inferred from direct assay	10753883	GOA
enables phosphatidylinositol phosphate 5-phosphatase activity	IMP IMP: Inferred from mutant phenotype	18774950	GOA
enables phosphatidylinositol trisphosphate phosphatase activity	IDA IDA: Inferred from direct assay	12556481	GOA
enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity	IDA IDA: Inferred from direct assay	21712384	GOA
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	IMP IMP: Inferred from mutant phenotype	28190456	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16002321	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to epidermal growth factor stimulus	IDA IDA: Inferred from direct assay	21712384	GOA
involved in cellular response to insulin stimulus	IDA IDA: Inferred from direct assay	12556481	GOA
involved in cellular response to tumor necrosis factor	IDA IDA: Inferred from direct assay	21712384	GOA
involved in dephosphorylation	IDA IDA: Inferred from direct assay	21712384	GOA
involved in dephosphorylation	IMP IMP: Inferred from mutant phenotype	18774950	GOA
involved in negative regulation by host of viral transcription	IDA IDA: Inferred from direct assay	18774950	GOA
involved in negative regulation of D-glucose transmembrane transport	IDA IDA: Inferred from direct assay	12556481	GOA
involved in negative regulation of MAP kinase activity	IDA IDA: Inferred from direct assay	12556481	GOA
involved in negative regulation of calcium ion transport	IDA IDA: Inferred from direct assay	12556481	GOA
involved in negative regulation of glycogen biosynthetic process	IDA IDA: Inferred from direct assay	12556481	GOA
involved in negative regulation of insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	12556481	GOA
involved in negative regulation of peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	12556481	GOA
involved in negative regulation of peptidyl-threonine phosphorylation	IDA IDA: Inferred from direct assay	12556481	GOA
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	12556481	GOA
involved in negative regulation of protein kinase activity	IDA IDA: Inferred from direct assay	12556481	GOA
involved in negative regulation of protein targeting to membrane	IDA IDA: Inferred from direct assay	12556481	GOA
involved in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	IDA IDA: Inferred from direct assay	18774950	GOA
involved in negative regulation of stress fiber assembly	IDA IDA: Inferred from direct assay	12556481	GOA
acts upstream of or within phosphatidylinositol dephosphorylation	IDA IDA: Inferred from direct assay	12536145	GOA
involved in phosphatidylinositol dephosphorylation	IDA IDA: Inferred from direct assay	12556481	GOA
involved in ruffle assembly	IDA IDA: Inferred from direct assay	12556481	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	10753883	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	12536145	GOA
located in membrane	IDA IDA: Inferred from direct assay	12536145	GOA
located in neuron projection	IDA IDA: Inferred from direct assay	10753883	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18774950	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	18774950	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	12556481	GOA
located in ruffle	IDA IDA: Inferred from direct assay	12536145	GOA
located in ruffle membrane	IDA IDA: Inferred from direct assay	12556481	GOA
located in trans-Golgi network	IDA IDA: Inferred from direct assay	12556481	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

INPP5K Protein Structure

Exo_endo_phos

0
100
200
300
400
448 a.a.

Protein Preferred Names

Protein Names

inositol polyphosphate 5-phosphatase K

phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase

INPP5K Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	INPP5K	Q9BT40	TNFRSF10D	Homo sapiens	Q9UBN6	Y2H Prey Pooling	32296183
Intra	INPP5K	Q9BT40	TNFRSF10D	Homo sapiens	Q9UBN6	Validated Y2H	32296183
Intra	INPP5K	Q9BT40	TNFRSF10D	Homo sapiens	Q9UBN6	Y2H Array	32296183
Intra	INPP5K	Q9BT40	KLK6	Homo sapiens	Q92876	Y2H Pooling	32814053
Intra	INPP5K	Q9BT40	KLK6	Homo sapiens	Q92876	Validated Y2H	32814053
Intra	INPP5K	Q9BT40	KLK6	Homo sapiens	Q92876	Y2H Array	32814053
Intra	INPP5K	Q9BT40	ATP5PF	Homo sapiens	P18859	Y2H Prey Pooling	32296183
Intra	INPP5K	Q9BT40	ATP5PF	Homo sapiens	P18859	Y2H Array	32296183
Intra	INPP5K	Q9BT40	FADS6	Homo sapiens	Q8N9I5	Y2H Array	32296183
Intra	INPP5K	Q9BT40	FADS6	Homo sapiens	Q8N9I5	Y2H Prey Pooling	32296183
Intra	INPP5K	Q9BT40	SFT2D2	Homo sapiens	O95562	Y2H Prey Pooling	32296183
Intra	INPP5K	Q9BT40	SFT2D2	Homo sapiens	O95562	Y2H Array	32296183
Intra	INPP5K	Q9BT40	GOLT1B	Homo sapiens	Q9Y3E0	Y2H Prey Pooling	32296183
Intra	INPP5K	Q9BT40	GOLT1B	Homo sapiens	Q9Y3E0	Y2H Array	32296183
Intra	INPP5K	Q9BT40	GOLT1B	Homo sapiens	Q9Y3E0	Validated Y2H	32296183
Intra	INPP5K	Q9BT40	MAD2L1BP	Homo sapiens	Q15013	Validated Y2H	25416956
Intra	INPP5K	Q9BT40	MAD2L1BP	Homo sapiens	Q15013	Y2H Prey Pooling	32296183
Intra	INPP5K	Q9BT40	MAD2L1BP	Homo sapiens	Q15013	Y2H Array	32296183
Intra	INPP5K	Q9BT40	MAD2L1BP	Homo sapiens	Q15013	Anti Tag CoIP	33961781
Intra	INPP5K	Q9BT40	ARL6IP1	Homo sapiens	Q15041	Y2H Prey Pooling	32296183
Intra	INPP5K	Q9BT40	ARL6IP1	Homo sapiens	Q15041	Y2H Array	32296183
Intra	INPP5K	Q9BT40	LNX1	Homo sapiens	Q8TBB1	Y2H	16002321
Intra	INPP5K	Q9BT40	LNX1	Homo sapiens	Q8TBB1	Anti Tag CoIP	16002321
Intra	INPP5K	Q9BT40	LNX1	Homo sapiens	Q8TBB1	IF	16002321
Intra	INPP5K	Q9BT40	PBX3	Homo sapiens	Q96AL5	Y2H Prey Pooling	32296183
Intra	INPP5K	Q9BT40	PBX3	Homo sapiens	Q96AL5	Y2H Array	32296183
Intra	INPP5K	Q9BT40	FATE1	Homo sapiens	Q969F0	Y2H Prey Pooling	25416956
Intra	INPP5K	Q9BT40	FATE1	Homo sapiens	Q969F0	Y2H Prey Pooling	32296183
Intra	INPP5K	Q9BT40	FATE1	Homo sapiens	Q969F0	Y2H Array	25416956
Intra	INPP5K	Q9BT40	FATE1	Homo sapiens	Q969F0	Y2H Array	32296183
Intra	INPP5K	Q9BT40	KRT31	Homo sapiens	Q15323	Validated Y2H	25416956
Intra	INPP5K	Q9BT40	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	INPP5K	Q9BT40	KRT31	Homo sapiens	Q15323	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Muscular Dystrophy, Congenital, With Cataracts And Intellectual Disability

Congenital Muscular Dystrophy With Cataracts And Intellectual Disability

MDCCAID

Marinesco-Sjogren Syndrome

Marinesco-Sjögren Syndrome	MSS
Marinesco-Garland Syndrome	Garland-Moorhouse Syndrome
Hereditary Oligophrenic Cerebello-Lental Degeneration	Oligophrenic Cerebellolenticular Degeneration
Marinesco-Sjogren Syndrome-Hypergonadotrophic Hypogonadism	Marinesco-Sjogren Syndrome-Myopathy
Marinesco-Sjogren-Garland Syndrome	Marinesco-Sjoegren Syndrome

Muscular Dystrophy

Muscular Dystrophies	Congenital Md
Congenital Muscular Dystrophy	Cmd
Mdc	Dystrophy, Muscular
Gower'S Muscular Dystrophy	Progressive Musclular Dystrophy
Pseudohypertrophic Atrophy	Pseudohypertrophic Muscle Paralysis
Pseudohypertrophic Muscular Atrophy	Pseudohypertrophic Muscular Dystrophy
Pseudohypertrophic Paralysis	Pseudomuscular Hypertrophy

Macrocephaly/Autism Syndrome

Macrocephaly-Autism Syndrome	Macrocephaly-Intellectual Disability-Autism Syndrome
MCEPHAS

Joubert Syndrome 1

Joubert Syndrome	Jbts
Cerebellooculorenal Syndrome 1	JBTS1
Joubert-Boltshauser Syndrome	Cerebelloparenchymal Disorder Iv
Cpd4	Cors1
Joubert Syndrome And Related Disorders	Jsrd
Familial Aplasia Of The Vermis	Joubert Syndrome Related Disorders
Js	Cerebellar Vermis Agenesis
Cerebelloparenchymal Disorder 4	Agenesis Of Cerebellar Vermis
Cerebello-Oculo-Renal Syndrome	Cors
Joubert-Bolthauser Syndrome	Cpd Iv
Classic Joubert Syndrome	Joubert Syndrome Type A
Pure Joubert Syndrome	Cerebello-Oculo-Renal Syndrome 1
Joubert Syndrome-1	Joubert Syndrome, Type 1
Joubert'S Syndrome

Muscular Dystrophy, Congenital, Lmna-Related

Congenital Muscular Dystrophy	Congenital Muscular Dystrophy Due To Lmna Mutation
MDCL	L-Cmd
Lmna-Related Congenital Muscular Dystrophy	Muscular Dystrophy, Congenital
Congenital Muscular Dystrophy Lmna-Related	Lmna-Related Cmd
Cmd	Mdc
Muscular Dystrophy Congenital Lmna-Related	Dystrophy, Muscular, Congenital, Lmna-Related
Dystrophy, Muscular, Congenital	Hereditary Muscular Dystrophy
Congenital Hereditary Muscular Dystrophy	Congenital Progressive Muscular Dystrophy
Hereditary Progressive Muscular Dystrophy

Lowe Oculocerebrorenal Syndrome

Lowe Syndrome	Oculocerebrorenal Syndrome
OCRL	Oculocerebrorenal Syndrome Of Lowe
Ocrl1	Phosphatidylinositol 4,5-Bisphosphate 5-Phosphatase Deficiency
Lowe Disease	Phosphatidylinositol 4,5-Biphosphate 5-Phosphatase Deficiency
Cerebrooculorenal Syndrome	Phosphatidylinositol-4,5-Bisphosphate-5-Phosphatase Deficiency
Lowe Oculo-Cerebro-Renal Dystrophy	Lowe Oculo-Cerebro-Renal Syndrome
Lowe Oculocerebrorenal Dystrophy	Low
Chromosome 11p Deletion Syndrome	Oculocerebrorenal Dystrophy
Cerebro-Oculorenal Dystrophy	Ocrl1 - [Oculocerebrorenal Syndrome]
Lowe-Terrey-Maclachlan Syndrome	Renal-Oculocerebrodystrophy

Hutchinson-Gilford Progeria Syndrome

Progeria	HGPS
Hutchinson-Gilford Syndrome	Hutchinson-Gilford Progeria
Hutchinson Gilford Syndrome	Hutchinson Gilford Progeria Syndrome
Hutchinson-Gilford Disease	Progeria Of Childhood
Hutchinson-Gilford-Progeria Syndrome

Cataract

Cataracts	Cat - [Cataract]
Cataract Form	Lens Opacity
Lens Opacities

Miller-Dieker Lissencephaly Syndrome

Miller-Dieker Syndrome	Mds
MDLS	Miller Dieker Syndrome
Classical Lissencephaly Syndrome	Lissencephaly Due To 17p13.3 Deletion
Monosomy 17p13.3	Telomeric Deletion 17p
Classical Lissencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06833	INPP5K Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	INPP5K	RGD	RGD:1359130
Bos taurus	INPP5K	VGNC	VGNC:30214
Mus musculus	INPP5K	MGD	MGI:1194899
Felis catus	INPP5K	VGNC	VGNC:62931
Canis familiaris	INPP5K	VGNC	VGNC:42036
Macaca mulatta	INPP5K	VGNC	VGNC:73695

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