MAD2L1BP - MAD2L1 binding protein Gene

Homo sapiens

Also known as CMT2

Gene ID: 9587 | Gene type: protein coding

About MAD2L1BP

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:43,629,540-43,640,941 (from NCBI)

This gene has 3 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in bone marrow (RPKM 14.5), duodenum (RPKM 8.6) and 25 other tissues.

Summary

The protein encoded by this gene was identified as a binding protein of the MAD2 mitotic arrest deficient-like 1 (MAD2/MAD2L1). MAD2 is a key component of the spindle checkpoint that delays the onset of anaphase until all the kinetochores are attached to the spindle. This protein may interact with the spindle checkpoint and coordinate cell cycle events in late mitosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

MAD2L1BP Products(2)

mRNA	Protein	Name
NM_001003690.2	NP_001003690.1	MAD2L1-binding protein isoform 1
NM_014628.3	NP_055443.1	MAD2L1-binding protein isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16169070	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in deactivation of mitotic spindle assembly checkpoint	IMP IMP: Inferred from mutant phenotype	18022368	GOA
involved in regulation of exit from mitosis	IMP IMP: Inferred from mutant phenotype	12456649	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10942595	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10942595	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAD2L1BP Protein Structure

p31comet

0
100
200
274 a.a.

Protein Preferred Names

Protein Names

MAD2L1-binding protein

caught by MAD2 protein

MAD2L1BP Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MAD2L1BP	Q15013	HOMEZ	Homo sapiens	Q8IX15-3	Y2H Prey Pooling	25416956
Intra	MAD2L1BP	Q15013	HOMEZ	Homo sapiens	Q8IX15-3	Y2H Array	25416956
Intra	MAD2L1BP	Q15013	ZBTB14	Homo sapiens	O43829	Validated Y2H	25416956
Intra	MAD2L1BP	Q15013	ZBTB14	Homo sapiens	O43829	Y2H Prey Pooling	32296183
Intra	MAD2L1BP	Q15013	ZBTB14	Homo sapiens	O43829	Y2H Array	32296183
Intra	MAD2L1BP	Q15013	FNDC8	Homo sapiens	Q8TC99	Y2H Array	32296183
Intra	MAD2L1BP	Q15013	FNDC8	Homo sapiens	Q8TC99	Y2H Prey Pooling	32296183
Intra	MAD2L1BP	Q15013	FNDC8	Homo sapiens	Q8TC99	Validated Y2H	32296183
Intra	MAD2L1BP	Q15013	TRIP13	Homo sapiens	Q15645	Y2H Pooling	16169070
Intra	MAD2L1BP	Q15013	TRIP13	Homo sapiens	Q15645	Y2H Array	31515488
Intra	MAD2L1BP	Q15013	TRIP13	Homo sapiens	Q15645	Pull Down	16189514
Intra	MAD2L1BP	Q15013	TRIP13	Homo sapiens	Q15645	Y2H Prey Pooling	32296183
Intra	MAD2L1BP	Q15013	TRIP13	Homo sapiens	Q15645	Y2H Array	19060904
Intra	MAD2L1BP	Q15013	TRIP13	Homo sapiens	Q15645	Validated Y2H	32296183
Intra	MAD2L1BP	Q15013	TRIP13	Homo sapiens	Q15645	Y2H Pooling	19060904
Intra	MAD2L1BP	Q15013	TRIP13	Homo sapiens	Q15645	Y2H Array	32296183
Intra	MAD2L1BP	Q15013	NMI	Homo sapiens	Q13287	Validated Y2H	25416956
Intra	MAD2L1BP	Q15013	NMI	Homo sapiens	Q13287	Y2H Array	25416956
Intra	MAD2L1BP	Q15013	INPP5K	Homo sapiens	Q9BT40	Y2H Prey Pooling	25416956
Intra	MAD2L1BP	Q15013	INPP5K	Homo sapiens	Q9BT40	Validated Y2H	32296183
Intra	MAD2L1BP	Q15013	INPP5K	Homo sapiens	Q9BT40	Y2H Array	25416956
Intra	MAD2L1BP	Q15013	INPP5K	Homo sapiens	Q9BT40	Y2H Array	29892012
Intra	MAD2L1BP	Q15013	INPP5K	Homo sapiens	Q9BT40	Anti Tag CoIP	33961781
Intra	MAD2L1BP	Q15013	ZNF202	Homo sapiens	O95125	Y2H Array	32296183
Intra	MAD2L1BP	Q15013	ZNF202	Homo sapiens	O95125	Y2H Prey Pooling	32296183
Intra	MAD2L1BP	Q15013	MAD2L1	Homo sapiens	Q13257	Pull Down	18022368
Intra	MAD2L1BP	Q15013	MAD2L1	Homo sapiens	Q13257	Anti Tag CoIP	18022368
Intra	MAD2L1BP	Q15013	MAD2L1	Homo sapiens	Q13257	Anti Tag CoIP	33961781
Intra	MAD2L1BP	Q15013	MAD2L1	Homo sapiens	Q13257	Anti Tag CoIP	21666598
Intra	MAD2L1BP	Q15013	MAD2L1	Homo sapiens	Q13257	Y2H Array	31515488
Intra	MAD2L1BP	Q15013	MAD2L1	Homo sapiens	Q13257	GMS	18022368
Intra	MAD2L1BP	Q15013	MAD2L1	Homo sapiens	Q13257	Y2H Array	25502805
Intra	MAD2L1BP	Q15013	MAD2L1	Homo sapiens	Q13257	Validated Y2H	25416956
Intra	MAD2L1BP	Q15013	MAD2L1	Homo sapiens	Q13257	Y2H Array	25416956
Intra	MAD2L1BP	Q15013	SGO2	Homo sapiens	Q562F6	Anti Tag CoIP	21666598

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07950	MAD2L1BP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MAD2L1BP	MGD	MGI:1913841
Bos taurus	MAD2L1BP	VGNC	VGNC:31131
Rattus norvegicus	MAD2L1BP	RGD	RGD:1309175
Canis familiaris	MAD2L1BP	VGNC	VGNC:42915
Macaca mulatta	MAD2L1BP	VGNC	VGNC:74325
Felis catus	MAD2L1BP	VGNC	VGNC:63360

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