CDK14 - cyclin dependent kinase 14 Gene

Homo sapiens

Also known as PFTK1; PFTAIRE1

Gene ID: 5218 | Gene type: protein coding

About CDK14

Cytogenetic location: 7q21.13 Genomic coordinates (GRCh38): 7:90,596,321-91,210,590 (from NCBI)

This gene has 15 transcripts (splice variants), 201 orthologues and 26 paralogues. Ubiquitous expression in brain (RPKM 6.5), kidney (RPKM 3.1) and 24 other tissues.

Summary

PFTK1 is a member of the CDC2 (MIM 116940)-related protein kinase family (Yang and Chen, 2001 [PubMed 11313143]).[supplied by OMIM, Mar 2008]

CDK14 Products(4)

mRNA	Protein	Name
NM_001287136.1	NP_001274065.1	cyclin-dependent kinase 14 isoform c
NM_001287137.1	NP_001274066.1	cyclin-dependent kinase 14 isoform d
NM_001287135.2	NP_001274064.1	cyclin-dependent kinase 14 isoform a
NM_012395.3	NP_036527.1	cyclin-dependent kinase 14 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cyclin binding	IPI IPI: Inferred from physical interaction	19524571	GOA
enables cyclin-dependent protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	19524571	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16775625	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in G2/M transition of mitotic cell cycle	IDA IDA: Inferred from direct assay	20059949	GOA
involved in regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	20059949	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of cyclin-dependent protein kinase holoenzyme complex	IPI IPI: Inferred from physical interaction	19524571	GOA
part of cytoplasmic cyclin-dependent protein kinase holoenzyme complex	IDA IDA: Inferred from direct assay	19524571	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	19524571	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDK14 Protein Structure

Pkinase

0
100
200
300
400
469 a.a.

Protein Preferred Names

Protein Names

cyclin-dependent kinase 14

PFTAIRE protein kinase 1	cell division protein kinase 14
serine/threonine-protein kinase PFTAIRE-1

CDK14 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CDK14	O94921	CCNY	Homo sapiens	Q8ND76	Y2H	19524571
Intra	CDK14	O94921	CCNY	Homo sapiens	Q8ND76	Anti Tag CoIP	19524571
Intra	CDK14	O94921	CCNY	Homo sapiens	Q8ND76	IF	19524571
Intra	CDK14	O94921	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	16775625
Intra	CDK14	O94921	YWHAH	Homo sapiens	Q04917	Y2H	16775625
Intra	CDK14	O94921	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	33961781
Intra	CDK14	O94921	YWHAE	Homo sapiens	P62258	Y2H	16775625
Intra	CDK14	O94921	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	16775625
Intra	CDK14	O94921	YWHAB	Homo sapiens	P31946	Anti Tag CoIP	16775625
Intra	CDK14	O94921	YWHAB	Homo sapiens	P31946	Y2H	16775625
Intra	CDK14	O94921	YWHAQ	Homo sapiens	P27348	Y2H	16775625
Intra	CDK14	O94921	CCND3	Homo sapiens	P30281	Y2H	17517622
Intra	CDK14	O94921	CCND3	Homo sapiens	P30281	Anti Bait CoIP	17517622
Intra	CDK14	O94921	CCND3	Homo sapiens	P30281	Anti Tag CoIP	17517622
Intra	CDK14	O94921	CDKN1A	Homo sapiens	P38936	Anti Bait CoIP	17517622
Intra	CDK14	O94921	CDKN1A	Homo sapiens	P38936	TAP	23602568
Intra	CDK14	O94921	CDKN1A	Homo sapiens	P38936	Anti Tag CoIP	33961781
Intra	CDK14	O94921	CDKN1A	Homo sapiens	P38936	Anti Tag CoIP	17517622

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-127104	FMF-04-159-2	Inhibitor	99.48%	Unkown
HY-X0150	JSH-150	Inhibitor	98.36%	Unkown
HY-X0009A	JSH-009 dimaleate	Inhibitor	/	Unkown
HY-160213	JA397	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CDK14	VGNC	VGNC:106680
Canis familiaris	CDK14	VGNC	VGNC:39046
Rattus norvegicus	CDK14	RGD	RGD:1305544
Macaca mulatta	CDK14	VGNC	VGNC:71164
Mus musculus	CDK14	MGD	MGI:894318
Felis catus	CDK14	VGNC	VGNC:68810
Others	CDK14	NCBI

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