SERPINI2 - serpin family I member 2 Gene

Homo sapiens

Also known as MEPI; PI14; PANCPIN; TSA2004

Gene ID: 5276 | Gene type: protein coding

About SERPINI2

Cytogenetic location: 3q26.1 Genomic coordinates (GRCh38): 3:167,441,933-167,476,963 (from NCBI)

This gene has 8 transcripts (splice variants), 104 orthologues and 36 paralogues. Restricted expression toward pancreas (RPKM 124.3).

Summary

The gene encodes a member of a family of proteins that acts as inhibitors of serine proteases. These proteins function in the regulation of a variety of physiological processes, including coagulation, fibrinolysis, development, malignancy, and inflammation. Expression of the encoded protein may be downregulated during pancreatic carcinogenesis. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]

SERPINI2 Products(3)

mRNA	Protein	Name
NM_001012303.3	NP_001012303.2	serpin I2 precursor
NM_001394327.1	NP_001381256.1	serpin I2 precursor
NM_006217.6	NP_006208.1	serpin I2 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SERPINI2 Protein Structure

Serpin

0
100
200
300
405 a.a.

Protein Preferred Names

Protein Names

serpin I2

myoepithelium-derived serine protease inhibitor

Recombinant SERPINI2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71039	Serpin I2 Protein, Human (HEK293, His)	O75830 (S19-L405 )	≥95%

Related Diseases

Diseases

Alias

Retinitis Pigmentosa 61

RP61	Retinitis Pigmentosa, Type 61

Cardiomyopathy, Dilated, 1o

Dilated Cardiomyopathy 1o	CMD1O
Dilated Cardiomyopathy With Ventricular Tachycardia	Cardiomyopathy, Dilated, With Ventricular Tachycardia
Cardiomyopathy, Dilated 1o	Cardiomyopathy, Dilated, Type 1o

Encephalopathy, Familial, With Neuroserpin Inclusion Bodies

Familial Encephalopathy With Neuroserpin Inclusion Bodies	FENIB
Encephalopathy, Familial, With Collins Bodies	Familial Dementia With Neuroserpin Inclusion Bodies
Familial Encephalopathy With Collins Bodies

Corneal Dystrophy, Meesmann, 1

Meesmann Corneal Dystrophy	Mecd
Corneal Dystrophy, Meesmann Epithelial	Juvenile Hereditary Epithelial Dystrophy
Corneal Dystrophy, Juvenile Epithelial Of Meesmann	MECD1
Meesmann Corneal Dystrophy 1	Meesmann Corneal Epithelial Dystrophy
Meesmann Epithelial Corneal Dystrophy	Corneal Dystrophy, Juvenile Epithelial, Of Meesmann
Stocker-Holt Dystrophy	Meesman Dystrophy
Meesman'S Corneal Dystrophy	Juvenile Hereditary Epithelial Dystrophy Of Meesmann
Corneal Dystrophy, Meesmann 1	Juvenile Epithelial Corneal Dystrophy Of Meesmann
Mcd	Dystrophy, Corneal, Meesmann

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12730	SERPINI2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SERPINI2	MGD	MGI:1915181
Macaca mulatta	SERPINI2	VGNC	VGNC:77367
Canis familiaris	SERPINI2	VGNC	VGNC:46043
Felis catus	SERPINI2	VGNC	VGNC:68835
Bos taurus	SERPINI2	VGNC	VGNC:34482
Rattus norvegicus	SERPINI2	RGD	RGD:619897
Others	SERPINI2	NCBI

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