PLRG1 - pleiotropic regulator 1 Gene

Homo sapiens

Also known as Cwc1; PRL1; PRP46; PRPF46; TANGO4

Gene ID: 5356 | Gene type: protein coding

About PLRG1

Cytogenetic location: 4q31.3 Genomic coordinates (GRCh38): 4:154,535,005-154,550,400 (from NCBI)

This gene has 13 transcripts (splice variants) and 219 orthologues. Ubiquitous expression in thyroid (RPKM 15.5), brain (RPKM 13.3) and 25 other tissues.

Summary

This gene encodes a core component of the cell division cycle 5-like (CDC5L) complex. The CDC5L complex is part of the spliceosome and is required for pre-mRNA splicing. The encoded protein plays a critical role in alternative splice site selection. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

PLRG1 Products(2)

mRNA	Protein	Name
NM_001201564.2	NP_001188493.1	pleiotropic regulator 1 isoform 2
NM_002669.4	NP_002660.1	pleiotropic regulator 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17332742	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	28076346	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of DNA replication factor A complex	IDA IDA: Inferred from direct assay	24332808	GOA
part of Prp19 complex	IPI IPI: Inferred from physical interaction	20176811	GOA
part of U2-type catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	28076346	GOA
part of catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	11991638	GOA
located in nucleus	IDA IDA: Inferred from direct assay	28076346	GOA
part of spliceosomal complex	IPI IPI: Inferred from physical interaction	20176811	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLRG1 Protein Structure

WD40

0
100
200
300
400
514 a.a.

Protein Preferred Names

Protein Names

pleiotropic regulator 1

pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)

PLRG1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PLRG1	O43660	BCAS2	Homo sapiens	O75934	Anti Bait CoIP	17353931
Intra	PLRG1	O43660	BCAS2	Homo sapiens	O75934	Crosslink	20176811
Intra	PLRG1	O43660	BCAS2	Homo sapiens	O75934	Anti Tag CoIP	33961781
Intra	PLRG1	O43660	SF3A2	Homo sapiens	Q15428	Affinity Chrom	17332742
Intra	PLRG1	O43660	CDC5L	Homo sapiens	Q99459	Anti Tag CoIP	33961781
Intra	PLRG1	O43660	CDC5L	Homo sapiens	Q99459	Anti Bait CoIP	17353931
Intra	PLRG1	O43660	CDC5L	Homo sapiens	Q99459	Far-WB	20176811
Intra	PLRG1	O43660	PRPF19	Homo sapiens	Q9UMS4	Crosslink	20176811
Intra	PLRG1	O43660	PRPF19	Homo sapiens	Q9UMS4	Anti Bait CoIP	17353931
Intra	PLRG1	O43660	PRPF19	Homo sapiens	Q9UMS4	Anti Tag CoIP	33961781
Intra	PLRG1	O43660	HNRNPM	Homo sapiens	P52272	IF	20467437
Intra	PLRG1	O43660	HNRNPM	Homo sapiens	P52272	Anti Bait CoIP	20467437
Intra	PLRG1	O43660	HNRNPM	Homo sapiens	P52272	Pull Down	20467437
Intra	PLRG1	O43660	HNRNPM	Homo sapiens	P52272	FRET	20467437

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Poikiloderma With Neutropenia

Poikiloderma With Neutropenia, Clericuzio Type	PN
Clericuzio Type Poikiloderma With Neutropenia	Poikiloderma With Neutropenia, Clericuzio-Type
Clericuzio-Type Poikiloderma With Neutropenia	Poikiloderma With Neutropenia Clericuzio Type
Immune-Deficient Poikiloderma	Clericuzio-Type Poikiloderma Neutropenia Syndrome
Poikiloderma With Neutropenia Clericuzio-Type	Poikiloderma, With Neutropenia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10738	PLRG1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PLRG1	MGD	MGI:1858197
Rattus norvegicus	PLRG1	RGD	RGD:621047
Bos taurus	PLRG1	VGNC	VGNC:33050
Macaca mulatta	PLRG1	VGNC	VGNC:76180
Canis familiaris	PLRG1	VGNC	VGNC:44710
Felis catus	PLRG1	VGNC	VGNC:68911

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