PPIL3 - peptidylprolyl isomerase like 3 Gene

Homo sapiens

Also known as CYPJ

Gene ID: 53938 | Gene type: protein coding

About PPIL3

Cytogenetic location: 2q33.1 Genomic coordinates (GRCh38): 2:200,870,907-200,889,291 (from NCBI)

This gene has 15 transcripts (splice variants), 129 orthologues and 22 paralogues. Ubiquitous expression in lymph node (RPKM 8.6), ovary (RPKM 7.0) and 25 other tissues.

Summary

This gene encodes a member of the Cyclophilin family. Cyclophilins catalyze the cis-trans isomerization of peptidylprolyl imide bonds in oligopeptides. They have been proposed to act either as catalysts or as molecular chaperones in protein-folding events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2008]

PPIL3 Products(2)

mRNA	Protein	Name
NM_032472.4	NP_115861.1	peptidyl-prolyl cis-trans isomerase-like 3 isoform PPIL3a
NM_130906.3	NP_570981.1	peptidyl-prolyl cis-trans isomerase-like 3 isoform PPIL3b

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	11991638	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPIL3 Protein Structure

Pro_isomerase

0
100
161 a.a.

Protein Preferred Names

Protein Names

peptidyl-prolyl cis-trans isomerase-like 3

PPIase

PPIL3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PPIL3	Q9H2H8	CENATAC	Homo sapiens	Q86UT8	Y2H Prey Pooling	32296183
Intra	PPIL3	Q9H2H8	CENATAC	Homo sapiens	Q86UT8	Y2H Array	32296183
Intra	PPIL3	Q9H2H8	SLU7	Homo sapiens	O95391	Anti Tag CoIP	33961781
Intra	PPIL3	Q9H2H8	SLU7	Homo sapiens	O95391	Y2H	22365833
Intra	PPIL3	Q9H2H8	SLU7	Homo sapiens	O95391	Validated Y2H	25416956
Cross	PPIL3	Q9H2H8	VP3	Chicken anemia virus	Q99152	Pull Down	18474220
Cross	PPIL3	Q9H2H8	VP3	Chicken anemia virus	Q99152	Y2H	18474220

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Estrogen-Receptor Negative Breast Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10956	PPIL3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PPIL3	VGNC	VGNC:103061
Mus musculus	PPIL3	MGD	MGI:1917475
Macaca mulatta	PPIL3	VGNC	VGNC:82208
Rattus norvegicus	PPIL3	RGD	RGD:631415
Bos taurus	PPIL3	VGNC	VGNC:33203

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