SLU7 - SLU7 homolog, splicing factor Gene

Homo sapiens

Also known as 9G8; hSlu7

Gene ID: 10569 | Gene type: protein coding

About SLU7

Cytogenetic location: 5q33.3 Genomic coordinates (GRCh38): 5:160,401,641-160,419,081 (from NCBI)

This gene has 9 transcripts (splice variants) and 206 orthologues. Ubiquitous expression in brain (RPKM 16.4), thyroid (RPKM 15.4) and 25 other tissues.

Summary

Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the spliceosome and contains a zinc knuckle motif that is found in other splicing factors and is involved in protein-nucleic acid and protein-protein interactions. [provided by RefSeq, Jul 2008]

SLU7 Products(7)

mRNA	Protein	Name
NM_001364517.2	NP_001351446.1	pre-mRNA-splicing factor SLU7 isoform a
NM_001364518.2	NP_001351447.1	pre-mRNA-splicing factor SLU7 isoform b
NM_001364520.2	NP_001351449.1	pre-mRNA-splicing factor SLU7 isoform b
NM_001364521.2	NP_001351450.1	pre-mRNA-splicing factor SLU7 isoform b
NM_001364522.2	NP_001351451.1	pre-mRNA-splicing factor SLU7 isoform c
NM_001364523.2	NP_001351452.1	pre-mRNA-splicing factor SLU7 isoform c
NM_006425.5	NP_006416.3	pre-mRNA-splicing factor SLU7 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables pre-mRNA 3'-splice site binding	IDA IDA: Inferred from direct assay	15728250	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables second spliceosomal transesterification activity	IDA IDA: Inferred from direct assay	10197984	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	15181151	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in RNA splicing, via transesterification reactions	IDA IDA: Inferred from direct assay	10197984	GOA
involved in alternative mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	15728250	GOA
involved in cellular response to heat	IDA IDA: Inferred from direct assay	21122810	GOA
involved in intracellular protein transport	IDA IDA: Inferred from direct assay	21122810	GOA
involved in mRNA 3'-splice site recognition	IDA IDA: Inferred from direct assay	15728250	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	11991638	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	21122810	GOA
located in nuclear speck	IDA IDA: Inferred from direct assay	15728250	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21122810	GOA
part of small nuclear ribonucleoprotein complex	IDA IDA: Inferred from direct assay	15181151	GOA
part of spliceosomal complex	IDA IDA: Inferred from direct assay	10197984	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLU7 Protein Structure

Slu7

0
100
200
300
400
500
586 a.a.

Protein Preferred Names

Protein Names

pre-mRNA-splicing factor SLU7

SLU7 splicing factor homolog

Related Diseases

Diseases

Alias

Alcoholic Gastritis

Alcoholic Gastritis, With Hemorrhage	Alcoholic Gastritis, Without Mention Of Hemorrhage
Alcohol Gastritis	Etoh Gastritis

Non-Syndromic X-Linked Intellectual Disability

X-Linked Non-Syndromic Intellectual Disability	Non-Specific X-Linked Mental Retardation
X-Linked Non-Specific Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13384	SLU7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SLU7	MGD	MGI:2385598
Canis familiaris	SLU7	VGNC	VGNC:46515
Bos taurus	SLU7	VGNC	VGNC:34971
Macaca mulatta	SLU7	VGNC	VGNC:77728
Felis catus	SLU7	VGNC	VGNC:65457
Rattus norvegicus	SLU7	RGD	RGD:631432

Name
Email *

	Sorry, but the email address you supplied was invalid.