2. Gene
  3. QKI - QKI, KH domain containing RNA binding Gene

QKI - QKI, KH domain containing RNA binding Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as QK; Hqk; QK1; QK3; hqkI

Gene ID: 9444 | Gene type: protein coding

About QKI

Cytogenetic location: 6q26 Genomic coordinates (GRCh38): 6:163,414,718-163,578,592 (from NCBI)

This gene has 17 transcripts (splice variants), 257 orthologues, 4 paralogues and is associated with 71 phenotypes. Broad expression in brain (RPKM 50.5), fat (RPKM 18.4) and 21 other tissues.

Summary

The protein encoded by this gene is an RNA-binding protein that regulates pre-mRNA splicing, export of mRNAs from the nucleus, protein translation, and mRNA stability. The encoded protein is involved in myelinization and oligodendrocyte differentiation and may play a role in schizophrenia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

QKI Products(5)

mRNA Protein Name
NM_001301085.2 NP_001288014.1 protein quaking isoform 5
NM_006775.3 NP_006766.1 protein quaking isoform 1
NM_206853.3 NP_996735.1 protein quaking isoform 2
NM_206854.3 NP_996736.1 protein quaking isoform 3
NM_206855.3 NP_996737.1 protein quaking isoform 4
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables internal N(7)-methylguanine-containing RNA reader activity IDA
IDA: Inferred from direct assay
37379838 GOA
enables mRNA 3'-UTR binding IDA
IDA: Inferred from direct assay
22398723 GOA
enables mRNA binding IDA
IDA: Inferred from direct assay
25768908 GOA
enables miRNA binding IDA
IDA: Inferred from direct assay
31792053 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence Reference Source
involved in intracellular mRNA localization IDA
IDA: Inferred from direct assay
37379838 GOA
involved in mRNA stabilization IDA
IDA: Inferred from direct assay
32732889 GOA
involved in mRNA transport IDA
IDA: Inferred from direct assay
37379838 GOA
involved in negative regulation of angiogenesis IDA
IDA: Inferred from direct assay
32732889 GOA
involved in negative regulation of macrophage differentiation IDA
IDA: Inferred from direct assay
22398723 GOA
involved in negative regulation of miRNA catabolic process IDA
IDA: Inferred from direct assay
31792053 GOA
involved in negative regulation of translation IDA
IDA: Inferred from direct assay
31829086 GOA
involved in negative regulation of type I interferon production IDA
IDA: Inferred from direct assay
31829086 GOA
involved in regulation of epithelial to mesenchymal transition IDA
IDA: Inferred from direct assay
25768908 GOA
involved in regulation of mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
27029405 GOA
involved in regulation of macrophage differentiation IDA
IDA: Inferred from direct assay
27029405 GOA
involved in spliceosome-depend formation of circular RNA IDA
IDA: Inferred from direct assay
25768908 GOA
involved in vascular associated smooth muscle cell differentiation IDA
IDA: Inferred from direct assay
31331967 GOA
Cellular Component GO Annotation Evidence Reference Source
is active in cytoplasmic stress granule IDA
IDA: Inferred from direct assay
37379838 GOA
is active in cytosol IDA
IDA: Inferred from direct assay
37379838 GOA
is active in nucleus IDA
IDA: Inferred from direct assay
37379838 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

QKI Protein Structure

KH_1

KH_1: KH domain (97 - 126)

  • 0
  • 100
  • 200
  • 300
  • 341 a.a.
Protein Preferred Names Protein Names

protein quaking

QKI/LOC100132735 fusion

QKI Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra QKI Q96PU8 MALT1 Homo sapiens Q9UDY8
Anti Bait CoIP
31774199
Intra QKI Q96PU8 CARM1 Homo sapiens Q86X55
Anti Tag CoIP
23455924
Intra QKI Q96PU8 NABP1 Homo sapiens Q96AH0
Validated Y2H
25416956
Intra QKI Q96PU8 NABP1 Homo sapiens Q96AH0
Y2H Array
25416956
Intra QKI Q96PU8 HNRNPK Homo sapiens P61978
Pull Down
16713569
Intra QKI Q96PU8 HNRNPK Homo sapiens P61978
Y2H Array
25416956
Intra QKI Q96PU8 HNRNPK Homo sapiens P61978
Y2H Array
29892012
Intra QKI Q96PU8 PTBP1 Homo sapiens P26599
Pull Down
16713569
Intra QKI Q96PU8 PTBP1 Homo sapiens P26599
Y2H
22365833
Intra QKI Q96PU8 HNRNPLL Homo sapiens Q8WVV9
Y2H Prey Pooling
25416956
Intra QKI Q96PU8 HNRNPLL Homo sapiens Q8WVV9
Y2H Array
25416956
Intra QKI Q96PU8 SNRPA Homo sapiens P09012
Y2H Array
25416956
Intra QKI Q96PU8 RBPMS Homo sapiens Q93062
Pull Down
16713569
Intra QKI Q96PU8 RBPMS Homo sapiens Q93062
Validated Y2H
25416956
Intra QKI Q96PU8 RBPMS Homo sapiens Q93062
Y2H Array
25416956
Intra QKI Q96PU8 RBM11 Homo sapiens P57052
Validated Y2H
25416956
Intra QKI Q96PU8 RBM11 Homo sapiens P57052
Y2H Prey Pooling
25416956
Intra QKI Q96PU8 RBFOX2 Homo sapiens O43251
Anti Tag CoIP
33961781
Intra QKI Q96PU8 RBFOX2 Homo sapiens O43251
Pull Down
16713569
Intra QKI Q96PU8 RBFOX2 Homo sapiens O43251
Y2H
22365833
Intra QKI Q96PU8 PCBP1 Homo sapiens Q15365
Y2H
16713569
Intra QKI Q96PU8 FUBP3 Homo sapiens Q96I24
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Angiocentric Glioma
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Pilomyxoid Astrocytoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11500 QKI Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta QKI VGNC VGNC:99431
Canis familiaris QKI VGNC VGNC:45232
Felis catus QKI VGNC VGNC:64456
Rattus norvegicus QKI RGD RGD:1584886
Mus musculus QKI MGD MGI:97837
Bos taurus QKI VGNC VGNC:33597
Others QKI NCBI