XRN1 - 5'-3' exoribonuclease 1 Gene

Homo sapiens

Also known as SEP1

Gene ID: 54464 | Gene type: protein coding

About XRN1

Cytogenetic location: 3q23 Genomic coordinates (GRCh38): 3:142,306,610-142,448,037 (from NCBI)

This gene has 14 transcripts (splice variants), 218 orthologues and 1 paralogue. Ubiquitous expression in appendix (RPKM 6.9), lymph node (RPKM 6.5) and 25 other tissues.

Summary

This gene encodes a member of the 5'-3' exonuclease family. The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts directly with the enhancer of mRNA-decapping protein 4. In addition to mRNA metabolism, a similar protein in yeast has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly. Mutations in this gene are associated with osteosarcoma, suggesting that the encoded protein may also play a role in bone formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

XRN1 Products(3)

mRNA	Protein	Name
NM_001282857.2	NP_001269786.1	5'-3' exoribonuclease 1 isoform c
NM_001282859.2	NP_001269788.1	5'-3' exoribonuclease 1 isoform d
NM_019001.5	NP_061874.3	5'-3' exoribonuclease 1 isoform a

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables 5'-3' RNA exonuclease activity	IMP IMP: Inferred from mutant phenotype	26950371	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15687258	GOA
enables telomerase RNA binding	IPI IPI: Inferred from physical interaction	26950371	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in histone mRNA catabolic process	IMP IMP: Inferred from mutant phenotype	18172165	GOA
involved in nuclear mRNA surveillance	IMP IMP: Inferred from mutant phenotype	17545563	GOA
involved in nuclear-transcribed mRNA catabolic process	IMP IMP: Inferred from mutant phenotype	17545563	GOA
involved in rRNA catabolic process	IMP IMP: Inferred from mutant phenotype	20368444	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

XRN1 Protein Structure

XRN_N

0
300
600
900
1200
1500
1706 a.a.

Protein Preferred Names

Protein Names

5'-3' exoribonuclease 1

strand-exchange protein 1 homolog

XRN1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	XRN1	Q8IZH2	EDC4	Homo sapiens	Q6P2E9	Pull Down	24510189

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Murray Valley Encephalitis

Australian Encephalitis	Australian X Disease
Encephalitis Australia	Murray River Encephalitis
Australian Arboencephalitis	Australian X Disorder
Mve - [Murray Valley Encephalitis]

Osteogenic Sarcoma

Osteosarcoma	OSRC
Osteosarcoma, Somatic	Neoplasms, Bone Tissue
Bone Tissue Neoplasm	Osteoid Sarcoma
Skeletal Sarcoma	Osteosarcoma Of Bone
Bone Sarcoma

Sarcoma

Connective And Soft Tissue Neoplasm	Tumor Of Soft Tissue And Skeleton
Sarcomas	Sarcoma - Category

Autosomal Recessive Nonsyndromic Deafness 32

Deafness, Autosomal Recessive 32	Autosomal Recessive Deafness 105
Autosomal Recessive Deafness 32	Dfnb32
Hearing Impairment Infertile Male Syndrome	Hiims
Deafness, Autosomal Recessive, Type 32

Alkhurma Hemorrhagic Fever

Alkhumra Haemorrhagic Fever

Zika Fever

Zika Virus Infection	Zika Virus Disease
Zika Virus	Zika Virus Fever
Mosquito-Borne Viral Fever, Zika

Perlman Syndrome

Nephroblastomatosis, Fetal Ascites, Macrosomia And Wilms Tumor	PRLMNS
Renal Hamartomas, Nephroblastomatosis, And Fetal Gigantism	Nephroblastomatosis Fetal Ascites Macrosomia And Wilms Tumor
Nephroblastomatosis, Fetal Ascites, Macrosomia, And Wilms Tumor	Nephroblastomatosis - Fetal Ascites - Macrosomia - Wilms Tumor
Renal Hamartomas, Nephroblastomatosis And Fetal Gigantism	Nephroblastomatosis-Fetal Ascites-Macrosomia-Wilms Tumor Syndrome
Renal Hamartomas Nephroblastomatosis And Fetal Gigantism	Nephroblastoma
Fetal Macrosomia

Kyasanur Forest Disease

Kfd	Monkey Fever
Kfd Virus	Kyasanur Hemorrhagic Fever
Monkey Disease	Monkey Diseases
Kfd - [ Kyasanur Forest Disease]	Monkey Sickness

Hemophagocytic Lymphohistiocytosis, Familial, 2

Familial Hemophagocytic Lymphohistiocytosis 2	FHL2
Hplh2	Hlh2
Hemophagocytic Lymphohistiocytosis, Familial, 2, Susceptibility To	Lymphohistiocytosis, Hemophagocytic, Familial, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15902	XRN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	XRN1	MGD	MGI:891964
Canis familiaris	XRN1	VGNC	VGNC:48471
Bos taurus	XRN1	VGNC	VGNC:37008
Rattus norvegicus	XRN1	RGD	RGD:1309713
Felis catus	XRN1	VGNC	VGNC:67122
Macaca mulatta	XRN1	VGNC	VGNC:79862

Name
Email *

	Sorry, but the email address you supplied was invalid.