EDC4 - enhancer of mRNA decapping 4 Gene

Homo sapiens

Also known as GE1; Ge-1; RCD8; HEDL5; HEDLS; RCD-8

Gene ID: 23644 | Gene type: protein coding

About EDC4

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:67,873,052-67,884,499 (from NCBI)

This gene has 14 transcripts (splice variants) and 212 orthologues. Ubiquitous expression in testis (RPKM 17.8), bone marrow (RPKM 15.0) and 25 other tissues.

Summary

Predicted to be involved in deadenylation-independent decapping of nuclear-transcribed mRNA. Located in P-body and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

EDC4 Products(1)

mRNA	Protein	Name
NM_014329.5	NP_055144.3	enhancer of mRNA-decapping protein 4

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15231747	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in P-body	IDA IDA: Inferred from direct assay	20826699	GOA
located in nucleus	IDA IDA: Inferred from direct assay	7520377	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

enhancer of mRNA-decapping protein 4

autoantigen Ge-1

EDC4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	EDC4	Q6P2E9	NBDY	Homo sapiens	A0A0U1RRE5	Crosslink	27918561
Intra	EDC4	Q6P2E9	NBDY	Homo sapiens	A0A0U1RRE5	Anti Tag CoIP	27918561
Intra	EDC4	Q6P2E9	NBDY	Homo sapiens	A0A0U1RRE5	Pull Down	27918561
Intra	EDC4	Q6P2E9	XRN1	Homo sapiens	Q8IZH2	Pull Down	24510189
Intra	EDC4	Q6P2E9	XRN1	Homo sapiens	Q8IZH2	Anti Bait CoIP	20584987
Intra	EDC4	Q6P2E9	XRN1	Homo sapiens	Q8IZH2	Anti Tag CoIP	24510189
Intra	EDC4	Q6P2E9	XRN1	Homo sapiens	Q8IZH2	Anti Tag CoIP	35271311
Intra	EDC4	Q6P2E9	DCP1A	Homo sapiens	Q9NPI6	IF	16364915
Intra	EDC4	Q6P2E9	DCP1A	Homo sapiens	Q9NPI6	Anti Tag CoIP	24510189
Intra	EDC4	Q6P2E9	DCP1A	Homo sapiens	Q9NPI6	Anti Tag CoIP	35271311
Intra	EDC4	Q6P2E9	DCP1A	Homo sapiens	Q9NPI6	Anti Tag CoIP	16364915
Intra	EDC4	Q6P2E9	DCP2	Homo sapiens	Q8IU60	Anti Tag CoIP	16364915
Intra	EDC4	Q6P2E9	DCP2	Homo sapiens	Q8IU60	Anti Tag CoIP	24510189
Intra	EDC4	Q6P2E9	DCP2	Homo sapiens	Q8IU60	Pull Down	24510189
Intra	EDC4	Q6P2E9	DCP2	Homo sapiens	Q8IU60-2	Anti Tag CoIP	16364915
Intra	EDC4	Q6P2E9	COASY	Homo sapiens	Q13057	Anti Bait CoIP	22982864

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Human Granulocytic Anaplasmosis

Human Granulocytic Ehrlichiosis	Hge
Human Ehrlichial Infection, Human Granulocytic Type	Human Anaplasmosis Due To Anaplasma Phagocytophilum

Spherocytosis, Type 2

Hereditary Spherocytosis Type 2	SPH2
Spherocytosis, Hereditary, 2	Hs2
Hereditary Spherocytosis 2	Spherocytosis 2
Spherocytosis, Type 2, Autosomal Dominant

Ulnar Neuropathy

Ulnar Neuropathies

Thoracic Outlet Syndrome

Tos	Tos - Thoracic Outlet Syndrome
Thoracic Outlet Syndromes	Thoracic Outlet Compression Syndrome

Ehrlichiosis

Human Ehrlichiosis	He
Hey

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04156	EDC4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	EDC4	VGNC	VGNC:72058
Bos taurus	EDC4	VGNC	VGNC:28321
Felis catus	EDC4	VGNC	VGNC:61721
Mus musculus	EDC4	MGD	MGI:2446249
Rattus norvegicus	EDC4	RGD	RGD:1562009
Canis familiaris	EDC4	VGNC	VGNC:40193

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