2. Gene
  3. PRMT7 - protein arginine methyltransferase 7 Gene

PRMT7 - protein arginine methyltransferase 7 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SBIDDS

Gene ID: 54496 | Gene type: protein coding

About PRMT7

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:68,311,019-68,360,870 (from NCBI)

This gene has 55 transcripts (splice variants), 206 orthologues, 7 paralogues and is associated with 3 phenotypes. Ubiquitous expression in small intestine (RPKM 5.3), testis (RPKM 5.1) and 25 other tissues.

Summary

This gene encodes a member of the protein arginine N-methyltransferase family of proteins. The encoded Enzyme transfers single methyl groups to arginine residues to generate monomethylarginines on histone proteins as well as other protein substrates. This Enzyme plays a role in a wide range of biological processes, including neuronal differentiation, male germ line imprinting, small nuclear ribonucleoprotein biogenesis, and regulation of the Wnt signaling pathway. Mutations in this gene underlie multiple related syndromes in human patients characterized by intellectual disability, short stature and other features. The encoded protein may promote breast Cancer cell invasion and metastasis in human patients. [provided by RefSeq, May 2017]

PRMT7 Products(64)

mRNA Protein Name
XM_017023292.3 XP_016878781.1 protein arginine N-methyltransferase 7 isoform X2
XM_011523112.4 XP_011521414.1 protein arginine N-methyltransferase 7 isoform X1
XM_011523121.4 XP_011521423.1 protein arginine N-methyltransferase 7 isoform X9
XM_047434235.1 XP_047290191.1 protein arginine N-methyltransferase 7 isoform X17
XM_011523116.4 XP_011521418.1 protein arginine N-methyltransferase 7 isoform X2
XM_047434226.1 XP_047290182.1 protein arginine N-methyltransferase 7 isoform X9
NM_001378020.1 NP_001364949.1 protein arginine N-methyltransferase 7 isoform 10
NR_147058.3
XR_007064885.1
XM_047434232.1 XP_047290188.1 protein arginine N-methyltransferase 7 isoform X15
NM_001351143.3 NP_001338072.1 protein arginine N-methyltransferase 7 isoform 4
XM_047434236.1 XP_047290192.1 protein arginine N-methyltransferase 7 isoform X18
XM_047434227.1 XP_047290183.1 protein arginine N-methyltransferase 7 isoform X10
XR_007064888.1
NR_165369.1
XR_002957814.2
XM_047434233.1 XP_047290189.1 protein arginine N-methyltransferase 7 isoform X16
NM_001378018.1 NP_001364947.1 protein arginine N-methyltransferase 7 isoform 1
XM_047434220.1 XP_047290176.1 protein arginine N-methyltransferase 7 isoform X5
XM_047434224.1 XP_047290180.1 protein arginine N-methyltransferase 7 isoform X8
XM_017023301.3 XP_016878790.1 protein arginine N-methyltransferase 7 isoform X12
XM_017023296.3 XP_016878785.1 protein arginine N-methyltransferase 7 isoform X4
XM_047434229.1 XP_047290185.1 protein arginine N-methyltransferase 7 isoform X12
NM_001290018.2 NP_001276947.1 protein arginine N-methyltransferase 7 isoform 1
XR_007064887.1
NR_147057.3
XM_047434230.1 XP_047290186.1 protein arginine N-methyltransferase 7 isoform X13
NM_001184824.4 NP_001171753.1 protein arginine N-methyltransferase 7 isoform 2
XM_047434222.1 XP_047290178.1 protein arginine N-methyltransferase 7 isoform X5
NR_165373.1
NR_165365.1
NR_147056.3
XM_017023300.3 XP_016878789.1 protein arginine N-methyltransferase 7 isoform X11
XM_047434239.1 XP_047290195.1 protein arginine N-methyltransferase 7 isoform X21
XM_017023297.3 XP_016878786.1 protein arginine N-methyltransferase 7 isoform X5
XM_017023304.3 XP_016878793.1 protein arginine N-methyltransferase 7 isoform X14
XM_017023299.3 XP_016878788.1 protein arginine N-methyltransferase 7 isoform X8
XM_047434234.1 XP_047290190.1 protein arginine N-methyltransferase 7 isoform X17
NR_165366.1
NM_001378021.1 NP_001364950.1 protein arginine N-methyltransferase 7 isoform 11
XR_001751915.3
XM_047434219.1 XP_047290175.1 protein arginine N-methyltransferase 7 isoform X3
XM_047434231.1 XP_047290187.1 protein arginine N-methyltransferase 7 isoform X15
NR_165370.1
XM_047434225.1 XP_047290181.1 protein arginine N-methyltransferase 7 isoform X9
NR_165368.1
XM_047434217.1 XP_047290173.1 protein arginine N-methyltransferase 7 isoform X1
XM_017023298.3 XP_016878787.1 protein arginine N-methyltransferase 7 isoform X6
XR_007064886.1
NM_019023.5 NP_061896.1 protein arginine N-methyltransferase 7 isoform 1
XM_047434237.1 XP_047290193.1 protein arginine N-methyltransferase 7 isoform X19
XM_047434218.1 XP_047290174.1 protein arginine N-methyltransferase 7 isoform X2
XM_011523113.4 XP_011521415.1 protein arginine N-methyltransferase 7 isoform X1
XM_047434238.1 XP_047290194.1 protein arginine N-methyltransferase 7 isoform X20
XM_047434228.1 XP_047290184.1 protein arginine N-methyltransferase 7 isoform X12
XM_047434221.1 XP_047290177.1 protein arginine N-methyltransferase 7 isoform X5
XM_011523115.4 XP_011521417.1 protein arginine N-methyltransferase 7 isoform X1
NM_001351144.3 NP_001338073.1 protein arginine N-methyltransferase 7 isoform 5
NR_165367.1
NR_165372.1
NM_001378022.1 NP_001364951.1 protein arginine N-methyltransferase 7 isoform 11
NM_001378023.1 NP_001364952.1 protein arginine N-methyltransferase 7 isoform 11
NR_165371.1
XM_047434223.1 XP_047290179.1 protein arginine N-methyltransferase 7 isoform X7
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables S-adenosylmethionine-dependent methyltransferase activity IDA
IDA: Inferred from direct assay
15044439 GOA
enables histone H4 methyltransferase activity IDA
IDA: Inferred from direct assay
15494416 GOA
enables histone binding IDA
IDA: Inferred from direct assay
15494416 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28587924 GOA
enables protein-arginine omega-N monomethyltransferase activity IDA
IDA: Inferred from direct assay
15044439 GOA
enables protein-arginine omega-N symmetric methyltransferase activity IDA
IDA: Inferred from direct assay
15494416 GOA
enables protein-arginine omega-N symmetric methyltransferase activity IMP
IMP: Inferred from mutant phenotype
17709427 GOA
enables ribonucleoprotein complex binding IPI
IPI: Inferred from physical interaction
17709427 GOA
Biological Process GO Annotation Evidence Reference Source
involved in peptidyl-arginine methylation IDA
IDA: Inferred from direct assay
15044439 GOA
involved in peptidyl-arginine methylation IMP
IMP: Inferred from mutant phenotype
17709427 GOA
involved in spliceosomal snRNP assembly IMP
IMP: Inferred from mutant phenotype
17709427 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytosol IDA
IDA: Inferred from direct assay
15494416 GOA
located in nucleus IDA
IDA: Inferred from direct assay
15494416 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRMT7 Protein Structure

PrmA

PrmA: Ribosomal protein L11 methyltransferase (PrmA) (65 - 124)

  • 0
  • 200
  • 400
  • 600
  • 692 a.a.
Protein Preferred Names Protein Names

protein arginine N-methyltransferase 7

[Myelin basic protein]-arginine N-methyltransferase PRMT7

histone-arginine N-methyltransferase PRMT7

Related Diseases

Diseases Alias
Primary Bone Dysplasia

Primary Osteodysplasia

Primary Skeletal Dysplasia
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Diabetes Mellitus, Non-Insulin-Dependent

Type 2 Diabetes

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
Osteochondrodysplasia

Chondrodystrophy

Skeletal Dysplasia

Congenital Anomaly Of Cartilage

Osteochondrodysplasias

Cartilage Development Disorder

Osteochondrodysplasia Syndrome

Dysplasia, Skeletal

Mucopolysaccharidosis Iv
Breast Cancer

Breast Carcinoma

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Male Breast Cancer

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Acanthosis Nigricans

Keratosis Nigricans

An
Fatty Liver Disease, Nonalcoholic 1

NAFLD1

Hepatic Steatosis

Fatty Liver Disease, Nonalcoholic, Susceptibility To, 1

Non-Alcoholic Fatty Liver Disease 1

Fatty Liver

Steatohepatitis
Short Stature, Brachydactyly, Impaired Intellectual Development, And Seizures

SBIDDS

Short Stature, Brachydactyly, Intellectual Developmental Disability, And Seizures

Short Stature-Brachydactyly-Obesity-Global Developmental Delay Syndrome

Short Stature, Brachydactyly, Impaired Intellectual Developmental, And Seizures
Coffin-Siris Syndrome 9

Mrd27

CSS9

Mental Retardation, Autosomal Dominant 27

Autosomal Dominant Mental Retardation 27

Autosomal Dominant Non-Syndromic Intellectual Disability 27

Coffin-Siris Syndrome, Type 9
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
Brachydactyly
Autosomal Recessive Disease

Autosomal Recessive Disorder
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Obesity , Susceptibility To

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
Testicular Cancer

Testis Cancer

Testicular Carcinoma

Testicular Neoplasms

Malignant Neoplasm Of Testis

Childhood Neoplasm Of The Testis

Neoplasm Of Testis

Pediatric Testicular Neoplasm

Testicular Tumor

Testis Neoplasm

Testicular Tumors

Testicular Neoplasm

Testicular Malignant Germ Cell Tumor

Childhood Testicular Neoplasm

Carcinoma Of The Testis

Cancer Of Testis

Malignant Neoplasm Of Testis, Nos

Malignant Neoplasm Of Testis, Unspecified

Malignant Tumour Of Testis

Testicle Cancer

Primary Malignant Neoplasm Of Testis
Renal Hypoplasia
Epilepsy, Progressive Myoclonic, 12

EPM12

Epilepsy, Progressive Myoclonic 12
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-112445 SGC3027 Inhibitor 98.29% Unkown
HY-124131 DS-437 Inhibitor 98.00% Unkown
HY-146810 PRMT4-IN-1 Inhibitor / Unkown
HY-114211 SGC8158 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PRMT7 VGNC VGNC:64362
Rattus norvegicus PRMT7 RGD RGD:1304869
Bos taurus PRMT7 VGNC VGNC:33352
Macaca mulatta PRMT7 VGNC VGNC:76315
Canis familiaris PRMT7 VGNC VGNC:45000
Mus musculus PRMT7 MGD MGI:2384879
Others PRMT7 NCBI