2. Gene
  3. Foxo4 - forkhead box O4 Gene

Foxo4 - forkhead box O4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as afx; Afxh; Mllt7

Gene ID: 54601 | Gene type: protein coding

About Foxo4

Summary

Enables sequence-specific DNA binding activity. Acts upstream of or within mitotic G2 DNA damage checkpoint signaling; negative regulation of cell population proliferation; and positive regulation of transcription, DNA-templated. Predicted to be located in cytosol and nuclear speck. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; early embryo; genitourinary system; inner cell mass; and sensory organ. Orthologous to human FOXO4 (forkhead box O4). [provided by Alliance of Genome Resources, Apr 2022]

Foxo4 Products(1)

mRNA Protein Name
NM_018789.2 NP_061259.1 forkhead box protein O4
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
19932102 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
11353388 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within mitotic G2 DNA damage checkpoint signaling IDA
IDA: Inferred from direct assay
12048180 MGI
acts upstream of or within negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
12048180 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12048180 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

forkhead box protein O4

fork head domain transcription factor AFX1

forkhead protein

myeloid/lymphoid or mixed lineage-leukemia translocation to 7 homolog

Foxo4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Cross
Foxo4 Q9WVH3 Ogt Rattus norvegicus P56558
Anti Tag CoIP
19932102
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-153347 JY-2 99.75% Unkown
HY-P4157 FOXO4-DRI 99.93% Unkown
HY-P4157A FOXO4-DRI acetate / Unkown
HY-RS05071 FOXO4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Foxo4 NCBI NCBI:4303