Ogt - O-linked N-acetylglucosamine (GlcNAc) transferase Gene

Rattus norvegicus

Gene ID: 26295 | Gene type: protein coding

About Ogt

Summary

Enables several functions, including identical protein binding activity; monosaccharide binding activity; and protein N-acetylglucosaminyltransferase activity. Involved in several processes, including intracellular distribution of mitochondria; negative regulation of protein targeting to membrane; and regulation of protein phosphorylation. Located in several cellular components, including euchromatin; neuronal cell body; and zymogen granule. Part of protein N-acetylglucosaminyltransferase complex. Biomarker of congestive heart failure. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 106. Orthologous to human OGT (O-linked N-acetylglucosamine (GlcNAc) transferase). [provided by Alliance of Genome Resources, Apr 2022]

Ogt Products(2)

mRNA	Protein	Name
NM_001398715.1	NP_001385644.1	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform 2
NM_017107.3	NP_058803.2	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	10542233	RGD
enables peptide binding	IDA IDA: Inferred from direct assay	10542233	RGD
enables protein O-acetylglucosaminyltransferase activity	IDA IDA: Inferred from direct assay	9083067	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12435728	RGD
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	24995978	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	1533623	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	21712532	RGD
involved in cellular response to insulin stimulus	IEP IEP: Inferred from expression pattern	15561949	RGD
involved in cellular response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	19098112	RGD
involved in cellular response to toxic substance	IEP IEP: Inferred from expression pattern	12054585	RGD
involved in forebrain development	IEP IEP: Inferred from expression pattern	22928023	RGD
involved in glucosamine metabolic process	IDA IDA: Inferred from direct assay	12054585	RGD
involved in glucosamine metabolic process	IMP IMP: Inferred from mutant phenotype	18539296	RGD
involved in intracellular distribution of mitochondria	IMP IMP: Inferred from mutant phenotype	24995978	RGD
involved in negative regulation of cellular response to hypoxia	IMP IMP: Inferred from mutant phenotype	18539296	RGD
involved in negative regulation of peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	21712532	RGD
involved in negative regulation of peptidyl-threonine phosphorylation	IMP IMP: Inferred from mutant phenotype	21712532	RGD
involved in negative regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	21712532	RGD
involved in negative regulation of protein targeting to membrane	IMP IMP: Inferred from mutant phenotype	21712532	RGD
involved in positive regulation of cell size	IMP IMP: Inferred from mutant phenotype	23665912	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	20978008	RGD
involved in positive regulation of protein localization to nucleus	IMP IMP: Inferred from mutant phenotype	16052526	RGD
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	20978008	RGD
involved in positive regulation of reactive oxygen species biosynthetic process	IMP IMP: Inferred from mutant phenotype	21712532	RGD
involved in protein O-linked glycosylation	IDA IDA: Inferred from direct assay	9083067	RGD
involved in protein O-linked glycosylation	IMP IMP: Inferred from mutant phenotype	24995978	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	12618343	RGD
is active in cerebellar granule cell to Purkinje cell synapse	IDA IDA: Inferred from direct assay	12618343	RGD
located in euchromatin	IDA IDA: Inferred from direct assay	10580430	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	12618343	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	22928023	RGD
is active in postsynaptic cytosol	IDA IDA: Inferred from direct assay	12618343	RGD
is active in presynaptic cytosol	IDA IDA: Inferred from direct assay	12618343	RGD
part of protein N-acetylglucosaminyltransferase complex	IDA IDA: Inferred from direct assay	10542233	RGD
located in zymogen granule	IDA IDA: Inferred from direct assay	10580430	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

O linked N-acetylglucosamine transferase	O-GlcNAc transferase subunit p110
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)	O-linked N-acetylglucosamine transferase 110 kDa subunit

Ogt Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Ogt	P56558	Nrf1	Mus musculus	Q9WU00	Anti Tag CoIP	26231763
Cross	Ogt	P56558	Foxo4	Mus musculus	Q9WVH3	Anti Tag CoIP	19932102

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-119738	OSMI-1	Inhibitor	99.90%	Unkown
HY-114361	OSMI-4	Inhibitor	99.55%	Unkown
HY-112174	UDP-GlcNAc disodium		≥99.0%	Unkown
HY-136282	OGT-IN-2	Inhibitor	99.82%	Unkown
HY-145934A	UDP-GlcNAz disodium		98.93%	Unkown
HY-139793	UDP-glucosamine disodium		99.43%	Unkown
HY-135784	OSMI-2	Inhibitor	98.73%	Unkown
HY-148113	PG 34		≥98.0%	Unkown
HY-119738A	(Rac)-OSMI-1	Inhibitor	96.51%	Unkown
HY-101548	OGT-IN-1	Inhibitor	98.14%	Unkown
HY-125278	OGT-IN-4	Inhibitor	/	Unkown
HY-135785	OSMI-3	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ogt	NCBI	NCBI:8473

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