PPID - peptidylprolyl isomerase D Gene

Homo sapiens

Also known as CYPD; CYP-40

Gene ID: 5481 | Gene type: protein coding

About PPID

Cytogenetic location: 4q32.1 Genomic coordinates (GRCh38): 4:158,709,127-158,723,396 (from NCBI)

This gene has 3 transcripts (splice variants), 243 orthologues and 22 paralogues. Ubiquitous expression in testis (RPKM 15.6), duodenum (RPKM 13.0) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein has been shown to possess PPIase activity and, similar to other family members, can bind to the immunosuppressant cyclosporin A. [provided by RefSeq, Jul 2008]

PPID Products(1)

mRNA	Protein	Name
NM_005038.3	NP_005029.1	peptidyl-prolyl cis-trans isomerase D

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables Hsp90 protein binding	IDA IDA: Inferred from direct assay	12145316	GOA
enables heat shock protein binding	IPI IPI: Inferred from physical interaction	9660753	GOA
enables peptidyl-prolyl cis-trans isomerase activity	IDA IDA: Inferred from direct assay	11350175	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9659917	GOA
enables transcription factor binding	IDA IDA: Inferred from direct assay	9659917	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to UV-A	IMP IMP: Inferred from mutant phenotype	23220213	GOA
involved in chaperone-mediated protein folding	IDA IDA: Inferred from direct assay	11350175	GOA
involved in lipid droplet organization	IMP IMP: Inferred from mutant phenotype	21711559	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18708059	GOA
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	23220213	GOA
involved in positive regulation of protein secretion	IMP IMP: Inferred from mutant phenotype	21711559	GOA
involved in positive regulation of viral genome replication	IMP IMP: Inferred from mutant phenotype	19932913	GOA
involved in protein-containing complex assembly	IDA IDA: Inferred from direct assay	18708059	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11525244	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	11525244	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11525244	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPID Protein Structure

Pro_isomerase

TPR_7

TPR_11

0
100
200
300
370 a.a.

Protein Preferred Names

Protein Names

peptidyl-prolyl cis-trans isomerase D

40 kDa peptidyl-prolyl cis-trans isomerase D

Recombinant PPID Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71224	PPID Protein, Human (His)	Q08752 (M1-A370)	≥95%

Related Diseases

Diseases

Alias

Anaplastic Large Cell Lymphoma

Alcl	Cd30 Positive Anaplastic Large Cell Lymphoma
Ki-1 Positive Anaplastic Large Cell Lymphoma	Primary Systemic Alcl
Sacl	Ki-1+ Anaplastic Large Cell Lymphoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10949	PPID Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PPID	RGD	RGD:1303174
Bos taurus	PPID	VGNC	VGNC:33197
Canis familiaris	PPID	VGNC	VGNC:44851
Felis catus	PPID	VGNC	VGNC:79975
Mus musculus	PPID	MGD	MGI:1914988
Others	PPID	NCBI

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