MED9 - mediator complex subunit 9 Gene

Homo sapiens

Also known as MED25

Gene ID: 55090 | Gene type: protein coding

About MED9

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:17,477,000-17,493,221 (from NCBI)

This gene has 5 transcripts (splice variants) and 203 orthologues. Ubiquitous expression in heart (RPKM 9.0), brain (RPKM 7.1) and 25 other tissues.

Summary

The multiprotein Mediator complex is a coactivator required for activation of RNA polymerase II transcription by DNA bound transcription factors. The protein encoded by this gene is thought to be a subunit of the Mediator complex. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

MED9 Products(1)

mRNA	Protein	Name
NM_018019.3	NP_060489.1	mediator of RNA polymerase II transcription subunit 9

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14638676	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of core mediator complex	IPI IPI: Inferred from physical interaction	24882805	GOA
located in nucleus	IDA IDA: Inferred from direct assay	24882805	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MED9 Protein Structure

Med9

0
100
146 a.a.

Protein Preferred Names

Protein Names

mediator of RNA polymerase II transcription subunit 9

mediator of RNA polymerase II transcription, subunit 9 homolog

Related Diseases

Diseases

Alias

Smith-Magenis Syndrome

SMS	Chromosome 17p11.2 Deletion Syndrome
17p11.2 Microdeletion Syndrome	17p11.2 Monosomy
Chromosome 17p Deletion Syndrome	Del(17)
P11.2	17p- Syndrome
Deletion 17p Syndrome	Partial Monosomy 17p

Jacobsen Syndrome

Chromosome 11q Deletion Syndrome	Partial 11q Monosomy Syndrome
Jacobsen Distal 11q Deletion Syndrome	JBS
11q Partial Monosomy Syndrome	Chromosome 11q Deletion
11q Deletion	11q Monosomy
Deletion 11q	Monosomy 11q
Partial Monosomy 11q	11q Deletion Disorder
11q Deletion Syndrome	11q Terminal Deletion Disorder
11q- Deletion Syndrome	11q23 Deletion Disorder
Jacobsen Thrombocytopenia	11q Terminal Deletion Syndrome
Del(11)(Q23.3)	Del(11)(Qter)
Distal Deletion 11q	Distal Monosomy 11q
Monosomy 11qter	Telomeric Deletion 11q
Paris-Trousseau Thrombocytopenia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08307	MED9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MED9	VGNC	VGNC:43142
Mus musculus	MED9	MGD	MGI:2183151
Felis catus	MED9	VGNC	VGNC:99277
Rattus norvegicus	MED9	RGD	RGD:1563669
Bos taurus	MED9	VGNC	VGNC:31370
Macaca mulatta	MED9	VGNC	VGNC:74577
Others	MED9	NCBI

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