WRAP53 - WD repeat containing antisense to TP53 Gene

Homo sapiens

Also known as DKCB3; TCAB1; WDR79

Gene ID: 55135 | Gene type: protein coding

About WRAP53

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,686,071-7,703,502 (from NCBI)

This gene has 16 transcripts (splice variants), 190 orthologues and is associated with 3 phenotypes. Ubiquitous expression in lymph node (RPKM 2.8), testis (RPKM 2.5) and 25 other tissues.

Summary

This gene encodes an essential component of the Telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for Telomerase function. It interacts with dyskerin, TERT and TERC, Other components of active Telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011]

WRAP53 Products(4)

mRNA	Protein	Name
NM_001143990.2	NP_001137462.1	telomerase Cajal body protein 1
NM_001143991.2	NP_001137463.1	telomerase Cajal body protein 1
NM_001143992.2	NP_001137464.1	telomerase Cajal body protein 1
NM_018081.2	NP_060551.2	telomerase Cajal body protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA binding	IDA IDA: Inferred from direct assay	19179534	GOA
enables RNA binding	IPI IPI: Inferred from physical interaction	20351177	GOA
enables RNA folding chaperone	IDA IDA: Inferred from direct assay	19179534	GOA
enables histone binding	IPI IPI: Inferred from physical interaction	26734725	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	21072240	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19179534	GOA
enables protein carrier chaperone	IMP IMP: Inferred from mutant phenotype	25467444	GOA
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	25467444	GOA
enables protein-folding chaperone binding	IPI IPI: Inferred from physical interaction	25467444	GOA
enables telomerase RNA binding	IDA IDA: Inferred from direct assay	22547674	GOA
enables telomerase RNA binding	IPI IPI: Inferred from physical interaction	20351177	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	25512560	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Cajal body organization	IMP IMP: Inferred from mutant phenotype	21072240	GOA
involved in RNA folding	IDA IDA: Inferred from direct assay	29804836	GOA
involved in positive regulation of DNA repair	IDA IDA: Inferred from direct assay	25512560	GOA
involved in positive regulation of double-strand break repair	IDA IDA: Inferred from direct assay	27715493	GOA
involved in positive regulation of double-strand break repair via homologous recombination	IDA IDA: Inferred from direct assay	25512560	GOA
involved in positive regulation of double-strand break repair via nonhomologous end joining	IDA IDA: Inferred from direct assay	25512560	GOA
involved in positive regulation of establishment of protein localization to telomere	IMP IMP: Inferred from mutant phenotype	25467444	GOA
acts upstream of positive regulation of telomere maintenance via telomerase	IDA IDA: Inferred from direct assay	23685356	GOA
involved in protein localization to Cajal body	IDA IDA: Inferred from direct assay	22547674	GOA
involved in scaRNA localization to Cajal body	IDA IDA: Inferred from direct assay	19285445	GOA
involved in scaRNA localization to Cajal body	IMP IMP: Inferred from mutant phenotype	25467444	GOA
involved in telomerase RNA localization to Cajal body	IMP IMP: Inferred from mutant phenotype	25467444	GOA
involved in telomere formation via telomerase	IMP IMP: Inferred from mutant phenotype	19179534	GOA
involved in telomere maintenance via telomerase	IDA IDA: Inferred from direct assay	29695869	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Cajal body	IDA IDA: Inferred from direct assay	19179534	GOA
located in Cajal body	IMP IMP: Inferred from mutant phenotype	25467444	GOA
located in site of double-strand break	IDA IDA: Inferred from direct assay	25512560	GOA
part of telomerase holoenzyme complex	IDA IDA: Inferred from direct assay	19179534	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WRAP53 Protein Structure

WD40

0
100
200
300
400
500
548 a.a.

Protein Preferred Names

Protein Names

telomerase Cajal body protein 1

WD repeat-containing protein 79

WRAP53 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	WRAP53	Q9BUR4	VAC14	Homo sapiens	Q08AM6	Y2H Array	32296183
Intra	WRAP53	Q9BUR4	VAC14	Homo sapiens	Q08AM6	Y2H Prey Pooling	32296183
Intra	WRAP53	Q9BUR4	UBAP2	Homo sapiens	Q5T6F2	Y2H Array	32296183
Intra	WRAP53	Q9BUR4	UBAP2	Homo sapiens	Q5T6F2	Y2H Prey Pooling	32296183
Intra	WRAP53	Q9BUR4	DKC1	Homo sapiens	O60832	Anti Bait CoIP	19179534
Intra	WRAP53	Q9BUR4	CCT2	Homo sapiens	P78371	Anti Bait CoIP	25467444
Intra	WRAP53	Q9BUR4	CCT3	Homo sapiens	P49368	Anti Tag CoIP	25467444
Intra	WRAP53	Q9BUR4	CCT2	Homo sapiens	P78371	Anti Tag CoIP	25467444
Intra	WRAP53	Q9BUR4	CCT3	Homo sapiens	P49368	Anti Bait CoIP	25467444
Intra	WRAP53	Q9BUR4	TCP1	Homo sapiens	P17987	Anti Tag CoIP	25467444
Intra	WRAP53	Q9BUR4	CCT3	Homo sapiens	P49368	Anti Tag CoIP	26496610
Intra	WRAP53	Q9BUR4	DKC1	Homo sapiens	O60832	Anti Tag CoIP	25467444
Intra	WRAP53	Q9BUR4	CCT2	Homo sapiens	P78371	Anti Tag CoIP	26496610
Intra	WRAP53	Q9BUR4	TCP1	Homo sapiens	P17987	Anti Bait CoIP	25467444
Intra	WRAP53	Q9BUR4	DKC1	Homo sapiens	O60832	Anti Tag CoIP	26496610
Intra	WRAP53	Q9BUR4	SMN1	Homo sapiens	Q16637	Anti Bait CoIP	21072240
Intra	WRAP53	Q9BUR4	SMN1	Homo sapiens	Q16637	Anti Tag CoIP	21072240
Intra	WRAP53	Q9BUR4	COIL	Homo sapiens	P38432	Anti Bait CoIP	21072240
Intra	WRAP53	Q9BUR4	COIL	Homo sapiens	P38432	Anti Tag CoIP	21072240
Cross	WRAP53	Q9BUR4	CCT6	Oryctolagus cuniculus	O77622	Anti Tag CoIP	25467444

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Dyskeratosis Congenita, Autosomal Recessive 3

DKCB3	Autosomal Recessive Dyskeratosis Congenita 3
Dyskeratosis Congenita, Autosomal Recessive, 3	Dyskeratosis Congenita, Autosomal Recessive, Type 3

Li-Fraumeni Syndrome

Sarcoma Family Syndrome Of Li And Fraumeni	Sbla Syndrome
LFS	Li-Fraumeni Familiar Cancer Susceptibility Syndrome
Sarcoma, Breast, Leukaemia And Adrenal Gland Syndrome	Lfs1
Li Fraumeni Syndrome	Sarcoma, Breast, Leukemia, And Adrenal Gland Syndrome
Lfl	Sbla Syndrome Li-Fraumeni-Like Syndrome
Li-Fraumeni Syndrome 1

Dyskeratosis Congenita

Dyskeratosis Congenita Autosomal Dominant	Dc
Dkc	Zinsser-Engman-Cole Syndrome
Dyskeratosis Congenita, Autosomal Dominant	Autosomal Dominant Dyskeratosis Congenita
Dkca	Dyskeratosis Congenita Scoggins Type
Zinsser-Cole-Engman Syndrome	X-Linked Dyskeratosis Congenita
Hoyeraal-Hreidarsson Syndrome

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Revesz Syndrome

Exudative Retinopathy With Bone Marrow Failure	DKCA5
Dyskeratosis Congenita, Autosomal Dominant 5	Dyskeratosis Congenita With Bilateral Exudative Retinopathy
Retinopathy-Anemia-Central Nervous System Anomalies Syndrome	Revesz-Debuse Syndrome
Dyskeratosis Congenita, Autosomal Dominant, 5	Revesz Debuse Syndrome

Dyskeratosis Congenita Autosomal Recessive

Autosomal Recessive Dyskeratosis Congenita	Dkcb
Dyskeratosis Congenita, Autosomal Recessive

Aplastic Anemia

Aplastic Anemia, Susceptibility To	Anemia Aplastic
Idiopathic Aplastic Anemia	Secondary Aplastic Anemia
Idiopathic Bone Marrow Failure	Aplastic Anemia Idiopathic
AA	Anemia, Aplastic
Aplastic Anemia, Idiopathic	Erythroid Aplasia
Aa - [Aplastic Anaemia]	Haematopoietic Aplasia
Aleukia Haemorrhagica	Anaemia Due To Decreased Red Cell Production
Aplasia Bone Marrow	Aplastic Bone Marrow
Hypoplastic Anaemia Nos	Myeloid Bone Marrow Aplasia
Pancytopenia	Panhaematopenia
Hypoproliferative Anaemia	Medullary Hypoplasia
Red Blood Cells Hypoplastic Anaemia	Panmyelophthisis
Panhemocytopenia	Refractive Hypoproliferative Anaemia
Toxic Anaemia	Toxic Aplastic Anaemia
Aplastic Anaemia Due To Toxic Cause	Idiopathic Aplastic Anaemia Nos

Dyskeratosis Congenita, Autosomal Dominant 1

DKCA1	Dyskeratosis Congenita, Scoggins Type
Autosomal Dominant Dyskeratosis Congenita 1	Dyskeratosis Congenita, Autosomal Dominant, Type 1
Dyskeratosis Congenita, Autosomal Dominant

Retinal Telangiectasia

Coats Disease

Exudative Retinopathy	Retinal Telangiectasis
Coats' Disease	Leber Miliary Aneurysm
Coats' Syndrome	Congenital Retinal Telangiectasia

Entropion

Melanoma, Cutaneous Malignant 1

Familial Melanoma	Melanoma, Cutaneous Malignant, Susceptibility To, 1
Melanoma, Malignant	CMM1
Melanoma, Cutaneous Malignant	Cmm
Familial Atypical Mole-Malignant Melanoma Syndrome	Fammm
Melanoma, Familial	Mlm
Dysplastic Nevus Syndrome, Hereditary	Dns
B-K Mole Syndrome	Melanoma, Cutaneous Malignant, 1
Malignant Melanoma, Cutaneous	Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1
Dysplastic Nevus Syndrome	Cutaneous Melanoma
Familial Atypical Mole Melanoma Syndrome	Hereditary Melanoma

Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia	Aase Syndrome
Erythrogenesis Imperfecta	Anemia, Diamond-Blackfan
Congenital Hypoplastic Anemia	Aase-Smith Ii Syndrome
Bds	Blackfan-Diamond Anemia
Congenital Prca	Congenital Hypoplastic Anemia, Blackfan-Diamond Type
Dba	Blackfan - Diamond Syndrome
Chronic Constitutional Pure Red Cell Anaemia	Anemia Diamond Blackfan Type
Anemia Congenital Erythroid Hypoplastic	Aregenerative Anemia Chronic Congenital
Blackfan Diamond Syndrome	Red Cell Aplasia, Pure Hereditary
Aase-Smith Syndrome Ii	Bda
Blackfan Diamond Anemia	Blackfan-Diamond Disease
Blackfan-Diamond Syndrome	Chronic Congenital Agenerative Anemia
Congenital Erythroid Hypoplastic Anemia	Congenital Hypoplastic Anemia Of Blackfan And Diamond
Congenital Pure Red Cell Anemia	Hypoplastic Congenital Anemia
Inherited Erythroblastopenia	Pure Hereditary Red Cell Aplasia
Anemia, Hypoplastic, Congenital	Anemia Hypoplastic Congenital
Fanconi Anemia	Constitutional Aplastic Anemia
Diamond-Blackfan Anemia 1	Aase Smith Syndrome 2
Congenital Red Cell Aplasia	Red Cell Aplasia Of Infants
Pure Red Cell Aplasia Of Infants	Congenital Red Cell Aplastic Anaemia
Congenital Pure Red Cell Anaemia	Congenital Erythroid Hypoplasia
Pearson Marrow-Pancreas Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15846	WRAP53 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	WRAP53	VGNC	VGNC:79508
Bos taurus	WRAP53	VGNC	VGNC:36968
Rattus norvegicus	WRAP53	RGD	RGD:1359624
Canis familiaris	WRAP53	VGNC	VGNC:48432
Mus musculus	WRAP53	MGD	MGI:2384933
Felis catus	WRAP53	VGNC	VGNC:67088

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