PPP2R5D - protein phosphatase 2 regulatory subunit B'delta Gene

Homo sapiens

Also known as B56D; MRD35; B56delta

Gene ID: 5528 | Gene type: protein coding

About PPP2R5D

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:42,984,570-43,012,342 (from NCBI)

This gene has 10 transcripts (splice variants), 207 orthologues, 4 paralogues and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 23.6), brain (RPKM 18.9) and 25 other tissues.

Summary

The product of this gene belongs to the Phosphatase 2A regulatory subunit B family. Protein Phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core Enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a delta isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

PPP2R5D Products(4)

mRNA	Protein	Name
NM_001270476.2	NP_001257405.1	serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform 4
NM_006245.4	NP_006236.1	serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform 1
NM_180976.3	NP_851307.1	serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform 2
NM_180977.3	NP_851308.1	serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform 3

PPP2R5D Protein Structure

B56

0
100
200
300
400
500
602 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

PPP2R5D Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PPP2R5D	Q14738	PPP2R1A	Homo sapiens	P30153	Anti Tag CoIP	26496610
Intra	PPP2R5D	Q14738	PPP2R1B	Homo sapiens	P30154	Y2H	23555304
Intra	PPP2R5D	Q14738	PPP2R1B	Homo sapiens	P30154	Anti Tag CoIP	26496610
Intra	PPP2R5D	Q14738	FSD2	Homo sapiens	A1L4K1	Y2H Array	25416956
Intra	PPP2R5D	Q14738	FSD2	Homo sapiens	A1L4K1	Validated Y2H	25416956
Intra	PPP2R5D	Q14738	USHBP1	Homo sapiens	Q8N6Y0	Y2H Prey Pooling	25416956
Intra	PPP2R5D	Q14738	DYDC1	Homo sapiens	Q8WWB3	Validated Y2H	32296183
Intra	PPP2R5D	Q14738	DYDC1	Homo sapiens	Q8WWB3	Y2H Array	32296183
Intra	PPP2R5D	Q14738	DYDC1	Homo sapiens	Q8WWB3	Y2H Prey Pooling	32296183
Intra	PPP2R5D	Q14738	PPFIA1	Homo sapiens	Q13136	Y2H Array	29892012
Intra	PPP2R5D	Q14738	PPFIA1	Homo sapiens	Q13136	Y2H Pooling	16189514
Intra	PPP2R5D	Q14738	PPFIA1	Homo sapiens	Q13136	Anti Tag CoIP	26496610
Intra	PPP2R5D	Q14738	SGO1	Homo sapiens	Q5FBB7	Y2H	21666598
Intra	PPP2R5D	Q14738	SGO1	Homo sapiens	Q5FBB7	Y2H	16541025

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder, Autosomal Dominant 35

MRD35	Intellectual Disability-Macrocephaly-Hypotonia-Behavioral Abnormalities Syndrome
Autosomal Dominant Non-Syndromic Intellectual Disability 35	Mental Retardation, Autosomal Dominant 35
Autosomal Dominant Intellectual Developmental Disorder 35	Autosomal Dominant Mental Retardation 35
Mental Retardation, Autosomal Dominant, Type 35

Encephalopathy

Brain Diseases	Encephalopathies
Toxic Encephalopathy	Toxic Brain Fever
Toxic Brain Inflammation	Toxic Brain Stem Inflammation
Toxic Cerebral Fever	Toxic Cerebrospinal Fever
Toxic Cerebrospinal Inflammation	Encephalopathy Nec
Encephalopathy Nos	Encephalopathy Disease
Encephalopathy Syndrome

Macrocephaly/Autism Syndrome

Macrocephaly-Autism Syndrome	Macrocephaly-Intellectual Disability-Autism Syndrome
MCEPHAS

Alzheimer Disease 8

Ad8	Alzheimer'S Disease 8
Alzheimer Disease, Familial, 8	Alzheimer Disease, Familial 8
Alzheimer'S Disease 8, Late Onset

Noonan Syndrome 4

NS4	Noonan Syndrome, Type 4

Intellectual Developmental Disorder, Autosomal Dominant 13

MRD13	Mental Retardation, Autosomal Dominant 13
Mental Retardation, Autosomal Dominant 13, With Neuronal Migration Defects	Autosomal Dominant Non-Syndromic Intellectual Disability 13
Autosomal Dominant Intellectual Developmental Disorder 13	Autosomal Dominant Mental Retardation 13
Mental Retardation, Autosomal Dominant, Type 13

Cornelia De Lange Syndrome

De Lange Syndrome	Brachmann De Lange Syndrome
Brachmann-De Lange Syndrome	Cdls
Bdls	Typus Degenerativus Amstelodamensis

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Lissencephaly

Pachygyria	Broad Gyri Of Cerebrum
Large Gyri Of Cerebrum	Macrogyria

Epilepsy, Myoclonic Juvenile

Juvenile Myoclonic Epilepsy	Janz Syndrome
Jme	Myoclonic Epilepsy, Juvenile, Susceptibility To, 1
EJM	Myoclonic Epilepsy, Juvenile
Petit Mal, Impulsive	Myoclonic Epilepsy, Juvenile 1
Myoclonic Epilepsy, Juvenile, 1	Adolescent Myoclonic Epilepsy
Juvenile Myoclonus Epilepsy	Juvenile Myoclonic Epilepsy 1
EJM1	Petit Mal Impulsive
Susceptibility To Juvenile Myoclonic Epilepsy 1	Myoclonic Epilepsy Juvenile
Epilepsy, Myoclonic, Juvenile	Myoclonic Epilepsy Of Janz
Jme - [Juvenile Myoclonic Epilepsy]

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11021	PPP2R5D Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PPP2R5D	RGD	RGD:1306666
Felis catus	PPP2R5D	VGNC	VGNC:69018
Macaca mulatta	PPP2R5D	VGNC	VGNC:76380
Mus musculus	PPP2R5D	MGD	MGI:2388481
Bos taurus	PPP2R5D	VGNC	VGNC:33263
Canis familiaris	PPP2R5D	VGNC	VGNC:44916

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