1. Gene
  2. LAPTM4B - lysosomal protein transmembrane 4 beta Gene

LAPTM4B - lysosomal protein transmembrane 4 beta Gene

Homo sapiens

Also known as LC27; LAPTM4beta

Gene ID: 55353 | Gene type: protein coding

About LAPTM4B

Cytogenetic location: 8q22.1 Genomic coordinates (GRCh38): 8:97,775,788-97,853,013 (from NCBI)

This gene has 4 transcripts (splice variants), 288 orthologues and 2 paralogues. Ubiquitous expression in heart (RPKM 97.2), testis (RPKM 52.3) and 23 other tissues.

Summary

Enables ceramide binding activity; Enzyme binding activity; and phosphatidylinositol bisphosphate binding activity. Involved in several processes, including negative regulation of macromolecule metabolic process; regulation of lysosomal membrane permeability; and regulation of lysosome organization. Located in several cellular components, including endosome; lysosomal membrane; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

LAPTM4B Products(1)

mRNA Protein Name
NM_018407.6 NP_060877.4 lysosomal-associated transmembrane protein 4B
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables ceramide binding IDA
IDA: Inferred from direct assay
26280656 GOA
enables kinase binding IPI
IPI: Inferred from physical interaction
25588945 GOA
enables phosphatidylinositol bisphosphate binding IDA
IDA: Inferred from direct assay
25588945 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20711237 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
25588945 GOA
Biological Process GO Annotation Evidence Reference Source
involved in endosome organization IMP
IMP: Inferred from mutant phenotype
21224396 GOA
involved in endosome transport via multivesicular body sorting pathway IDA
IDA: Inferred from direct assay
25588945 GOA
involved in negative regulation of lysosomal protein catabolic process IMP
IMP: Inferred from mutant phenotype
25588945 GOA
involved in negative regulation of transforming growth factor beta1 production IDA
IDA: Inferred from direct assay
26126825 GOA
involved in regulation of lysosomal membrane permeability IMP
IMP: Inferred from mutant phenotype
26280656 GOA
involved in regulation of lysosome organization IMP
IMP: Inferred from mutant phenotype
26280656 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cell projection IDA
IDA: Inferred from direct assay
22096579 GOA
located in early endosome IDA
IDA: Inferred from direct assay
25588945 GOA
located in endosome IDA
IDA: Inferred from direct assay
25588945 GOA
located in late endosome membrane IDA
IDA: Inferred from direct assay
21224396 GOA
located in lysosomal membrane IDA
IDA: Inferred from direct assay
21224396 GOA
located in lysosome IDA
IDA: Inferred from direct assay
25588945 GOA
located in multivesicular body membrane IDA
IDA: Inferred from direct assay
25588945 GOA
located in multivesicular body, internal vesicle IDA
IDA: Inferred from direct assay
26280656 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
22096579 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LAPTM4B Protein Structure

Mtp

Mtp: Golgi 4-transmembrane spanning transporter (155 - 317)

  • 0
  • 100
  • 200
  • 317 a.a.
Protein Preferred Names Protein Names

lysosomal-associated transmembrane protein 4B

lysosomal associated protein transmembrane 4 beta

Related Diseases

Diseases Alias
Gallbladder Cancer

Gallbladder Carcinoma

Gallbladder Neoplasm

Malignant Neoplasm Of Gallbladder

Malignant Tumour Of Gallbladder

Gallbladder Ca

Localized Malignant Gallbladder Neoplasm

Malignant Tumor Of The Gallbladder

Tumor Of The Gallbladder

Cancer Of The Gallbladder

Carcinoma Gallbladder

Carcinoma Of Gallbladder

Gallbladder Neoplasms

Malignant Neoplasm Of Gallbladder Localized

Cancer Of Gallbladder

Primary Malignant Neoplasm Of Gallbladder

Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus LAPTM4B VGNC VGNC:81664
Canis familiaris LAPTM4B VGNC VGNC:54319
Mus musculus LAPTM4B MGD MGI:1890494
Macaca mulatta LAPTM4B VGNC VGNC:84010
Rattus norvegicus LAPTM4B RGD RGD:1311853