2. Gene
  3. MCM10 - minichromosome maintenance 10 replication initiation factor Gene

MCM10 - minichromosome maintenance 10 replication initiation factor Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CNA43; DNA43; IMD80; PRO2249

Gene ID: 55388 | Gene type: protein coding

About MCM10

Cytogenetic location: 10p13 Genomic coordinates (GRCh38): 10:13,161,558-13,211,110 (from NCBI)

This gene has 7 transcripts (splice variants), 203 orthologues and is associated with 1 phenotype. Broad expression in bone marrow (RPKM 2.8), lymph node (RPKM 2.2) and 15 other tissues.

Summary

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of Other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

MCM10 Products(2)

mRNA Protein Name
NM_018518.5 NP_060988.3 protein MCM10 homolog isoform 2
NM_182751.3 NP_877428.1 protein MCM10 homolog isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
17823614 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11095689 GOA
Biological Process GO Annotation Evidence Reference Source
involved in DNA damage response IMP
IMP: Inferred from mutant phenotype
24726359 GOA
involved in DNA replication initiation IMP
IMP: Inferred from mutant phenotype
32865517 GOA
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
11095689 GOA
located in nucleus IMP
IMP: Inferred from mutant phenotype
32865517 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MCM10 Protein Structure

zf-primase

zf-primase: Primase zinc finger (382 - 427)

Mcm10

Mcm10: Mcm10 replication factor (523 - 873)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 875 a.a.
Protein Preferred Names Protein Names

protein MCM10 homolog

MCM10 minichromosome maintenance deficient 10

MCM10 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
MCM10 Q7L590 MCM6 Homo sapiens Q14566
Anti Tag CoIP
35271311
Intra
MCM10 Q7L590 MCM6 Homo sapiens Q14566
Protein Array
15232106
Intra
MCM10 Q7L590 CDC6 Homo sapiens Q99741
Protein Array
15232106
Intra
MCM10 Q7L590 CDC45 Homo sapiens O75419
Protein Array
15232106
Intra
MCM10 Q7L590 CEP72 Homo sapiens Q9P209
Y2H Array
31515488
Intra
MCM10 Q7L590 CDC7 Homo sapiens O00311
Protein Array
15232106
Intra
MCM10 Q7L590 CDK6 Homo sapiens Q00534
Protein Array
15232106
Intra
MCM10 Q7L590 ORC2 Homo sapiens Q13416
Y2H
11095689
Intra
MCM10 Q7L590 CEP72 Homo sapiens Q9P209
Y2H Pooling
16189514
Intra
MCM10 Q7L590 CCND3 Homo sapiens P30281
Protein Array
15232106
Intra
MCM10 Q7L590 MCM10 Homo sapiens Q7L590
GMS
17823614
Intra
MCM10 Q7L590 CDC5L Homo sapiens Q99459
Protein Array
15232106
Intra
MCM10 Q7L590 MCM10 Homo sapiens Q7L590
EM
17823614
Intra
MCM10 Q7L590 CCND1 Homo sapiens P24385
Protein Array
15232106
Intra
MCM10 Q7L590 ORC2 Homo sapiens Q13416
Anti Bait CoIP
11095689
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Immunodeficiency 80 With Or Without Congenital Cardiomyopathy

IMD80

Mcm10 Deficiency

Immunodeficiency 80 With Or Without Cardiomyopathy
Nk Cell Deficiency
Restrictive Cardiomyopathy

Familial Restrictive Cardiomyopathy

Cardiomyopathy, Restrictive

Cardiomyopathy, Constrictive

Primary Restrictive Cardiomyopathy

Rcm

Cardiomyopathy Restrictive
Endometrial Mixed Adenocarcinoma
Baller-Gerold Syndrome

BGS

Craniosynostosis With Radial Defects

Craniosynostosis-Radial Aplasia Syndrome

Craniosynostosis Radial Aplasia Syndrome
Rapadilino Syndrome

Absent Thumbs, Dislocated Joints, Long Face With Narrow Palpebral Fissures, Long Slender Nose, Arched Palate

Radial And Patellar Aplasia

Radial And Patellar Hypoplasia

RAPADILINOS
Ovary Serous Adenocarcinoma

Malignant Ovarian Serous Tumor

Serous Carcinoma Of Ovary
Filippi Syndrome

Scott Craniodigital Syndrome With Mental Retardation

Type 1 Syndactyly-Microcephaly-Intellectual Disability Syndrome

FLPIS

Scott Bryant Graham Syndrome

Craniodigital-Intellectual Disability Syndrome

Scott Craniodigital Syndrome

Scott-Bryant-Graham Syndrome

Syndactyly, Type I, With Microcephaly And Mental Retardation

Syndactyly Type I With Microcephaly And Intellectual Disability

Unusual Facial Appearance, Microcephaly, Growth And Intellectual Disability And Syndactyly

Craniodigital Syndrome With Intellectual Disability

Craniodigital Syndrome-Intellectual Disability Syndrome

Craniodigital Syndrome-Intellectual Disability, Scott Type

Intellectual Disability-Craniodigital Syndrome
Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia
Meier-Gorlin Syndrome 1

Meier-Gorlin Syndrome

Ear, Patella, Short Stature Syndrome

Microtia, Absent Patellae, Micrognathia Syndrome

MGORS1

Eps

Ear-Patella-Short Stature Syndrome

Ear Patella Short Stature Syndrome

Microtia Absent Patellae Micrognathia Syndrome

Meier-Gorlin Syndrome, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08233 MCM10 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus MCM10 VGNC VGNC:31307
Macaca mulatta MCM10 VGNC VGNC:74528
Mus musculus MCM10 MGD MGI:1917274
Felis catus MCM10 VGNC VGNC:63414
Rattus norvegicus MCM10 RGD RGD:1311330
Canis familiaris MCM10 VGNC VGNC:43080