2. Gene
  3. CDC7 - cell division cycle 7 Gene

CDC7 - cell division cycle 7 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as Hsk1; CDC7L1; HsCDC7; huCDC7

Gene ID: 8317 | Gene type: protein coding

About CDC7

Cytogenetic location: 1p22.1 Genomic coordinates (GRCh38): 1:91,500,851-91,525,764 (from NCBI)

This gene has 5 transcripts (splice variants), 209 orthologues and 12 paralogues. Broad expression in testis (RPKM 10.5), lymph node (RPKM 4.8) and 19 other tissues.

Summary

This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same protein have been detected. [provided by RefSeq, Aug 2008]

CDC7 Products(3)

mRNA Protein Name
NM_001134419.2 NP_001127891.1 cell division cycle 7-related protein kinase
NM_001134420.2 NP_001127892.1 cell division cycle 7-related protein kinase
NM_003503.4 NP_003494.1 cell division cycle 7-related protein kinase
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables kinase activity IDA
IDA: Inferred from direct assay
9250678 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12065429 GOA
enables protein kinase activity IMP
IMP: Inferred from mutant phenotype
12065429 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cell cycle phase transition IMP
IMP: Inferred from mutant phenotype
17102137 GOA
involved in positive regulation of G2/M transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
15668232 GOA
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
17102137 GOA
involved in positive regulation of nuclear cell cycle DNA replication IMP
IMP: Inferred from mutant phenotype
15668232 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
9250678 GOA
located in nucleus IDA
IDA: Inferred from direct assay
9250678 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDC7 Protein Structure

Pkinase

Pkinase: Protein kinase domain (58 - 204)

Pkinase

Pkinase: Protein kinase domain (365 - 569)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 574 a.a.
Protein Preferred Names Protein Names

cell division cycle 7-related protein kinase

CDC7 (cell division cycle 7, S. cerevisiae, homolog)-like 1

Related Diseases

Diseases Alias
Glaucoma, Primary Open Angle

Glaucoma 1, Open Angle, E

Primary Open Angle Glaucoma

POAG

Adult-Onset Primary Open Angle Glaucoma

Chronic Simple Glaucoma

GLC1E

Primary Open Angle Glaucoma 1e

Glaucoma, Open Angle, Primary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-100888 Simurosertib Inhibitor 99.94% Phase 2
HY-143430A (S)-LY3177833 hydrate Inhibitor / Phase 1
Pre-clinical Phase
Bioactive Molecules (33)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15260A XL413 monohydrochloride Inhibitor 99.72% Unkown
HY-13461A PHA-767491 hydrochloride 98.06% Unkown
HY-133028 CKI-7 free base Inhibitor 99.80% Unkown
HY-100023 LY3177833 Inhibitor 99.48% Unkown
HY-15260 XL413 Inhibitor 99.76% Unkown
HY-100888A (R)-Simurosertib 99.58% Unkown
HY-101523 Cdc7-IN-1 Inhibitor 99.77% Unkown
HY-130517 Cdc7-IN-5 Inhibitor 96.73% Unkown
HY-100023A LY3177833 monhydrate Inhibitor 99.76% Unkown
HY-148065 FMF-06-098-1 / Unkown
HY-13461 PHA-767491 Inhibitor 99.85% Unkown
HY-130516 Cdc7-IN-4 Inhibitor / Unkown
HY-130515 Cdc7-IN-3 Inhibitor / Unkown
HY-130519 Cdc7-IN-7 Inhibitor / Unkown
HY-117677 Cdc7-IN-21 Inhibitor / Unkown
HY-143377 Cdc7-IN-8 Inhibitor / Unkown
HY-143380 Cdc7-IN-9 Inhibitor / Unkown
HY-143381 Cdc7-IN-10 Inhibitor / Unkown
HY-143383 Cdc7-IN-11 Inhibitor / Unkown
HY-143385 Cdc7-IN-12 Inhibitor / Unkown
HY-143387 Cdc7-IN-13 Inhibitor / Unkown
HY-143389 Cdc7-IN-14 Inhibitor / Unkown
HY-143429 Cdc7-IN-15 Inhibitor / Unkown
HY-143430 (S)-LY3177833 Inhibitor / Unkown
HY-143431 Cdc7-IN-17 Inhibitor / Unkown
HY-143432 Cdc7-IN-18 Inhibitor / Unkown
HY-143432A (S)-Cdc7-IN-18 Inhibitor / Unkown
HY-143433 Cdc7-IN-19 Inhibitor / Unkown
HY-15260C XL413 hydrochloride Inhibitor / Unkown
HY-162007 PYRA-2 Inhibitor / Unkown
HY-163374 Cdc7-IN-20 Inhibitor / Unkown
HY-RS02309 CDC7 Human Pre-designed siRNA Set A / Unkown
HY-W011109 CKI-7 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CDC7 VGNC VGNC:80164
Mus musculus CDC7 MGD MGI:1309511
Canis familiaris CDC7 VGNC VGNC:39010
Macaca mulatta CDC7 VGNC VGNC:106340
Rattus norvegicus CDC7 RGD RGD:1308351
Bos taurus CDC7 VGNC VGNC:27082
Others CDC7 NCBI