CDC7 - cell division cycle 7 Gene

Homo sapiens

Also known as Hsk1; CDC7L1; HsCDC7; huCDC7

Gene ID: 8317 | Gene type: protein coding

About CDC7

Cytogenetic location: 1p22.1 Genomic coordinates (GRCh38): 1:91,500,851-91,525,764 (from NCBI)

This gene has 5 transcripts (splice variants), 209 orthologues and 12 paralogues. Broad expression in testis (RPKM 10.5), lymph node (RPKM 4.8) and 19 other tissues.

Summary

This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same protein have been detected. [provided by RefSeq, Aug 2008]

CDC7 Products(3)

mRNA	Protein	Name
NM_001134419.2	NP_001127891.1	cell division cycle 7-related protein kinase
NM_001134420.2	NP_001127892.1	cell division cycle 7-related protein kinase
NM_003503.4	NP_003494.1	cell division cycle 7-related protein kinase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables kinase activity	IDA IDA: Inferred from direct assay	9250678	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12065429	GOA
enables protein kinase activity	IMP IMP: Inferred from mutant phenotype	12065429	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell cycle phase transition	IMP IMP: Inferred from mutant phenotype	17102137	GOA
involved in positive regulation of G2/M transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	15668232	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	17102137	GOA
involved in positive regulation of nuclear cell cycle DNA replication	IMP IMP: Inferred from mutant phenotype	15668232	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	9250678	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9250678	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDC7 Protein Structure

Pkinase

0
100
200
300
400
500
574 a.a.

Protein Preferred Names

Protein Names

cell division cycle 7-related protein kinase

CDC7 (cell division cycle 7, S. cerevisiae, homolog)-like 1

CDC7 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CDC7	O00311	TMBIM6	Homo sapiens	P55061	Validated Y2H	32296183
Intra	CDC7	O00311	FXR1	Homo sapiens	P51114-2	Y2H Prey Pooling	32296183
Intra	CDC7	O00311	FXR1	Homo sapiens	P51114-2	Validated Y2H	32296183
Intra	CDC7	O00311	FXR1	Homo sapiens	P51114-2	Y2H Array	32296183
Intra	CDC7	O00311	GOLGA6A	Homo sapiens	Q9NYA3	Y2H Prey Pooling	32296183
Intra	CDC7	O00311	GOLGA6A	Homo sapiens	Q9NYA3	Validated Y2H	32296183
Intra	CDC7	O00311	GOLGA6A	Homo sapiens	Q9NYA3	Y2H Array	32296183
Intra	CDC7	O00311	IKZF1	Homo sapiens	Q13422-7	Y2H Prey Pooling	32296183
Intra	CDC7	O00311	IKZF1	Homo sapiens	Q13422-7	Y2H Array	32296183
Intra	CDC7	O00311	IKZF1	Homo sapiens	Q13422-7	Validated Y2H	32296183
Intra	CDC7	O00311	MTUS2	Homo sapiens	Q5JR59-3	Validated Y2H	32296183
Intra	CDC7	O00311	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	32296183
Intra	CDC7	O00311	MTUS2	Homo sapiens	Q5JR59-3	Y2H Prey Pooling	32296183
Intra	CDC7	O00311	BANP	Homo sapiens	Q8N9N5-2	Y2H Prey Pooling	32296183
Intra	CDC7	O00311	BANP	Homo sapiens	Q8N9N5-2	Validated Y2H	32296183
Intra	CDC7	O00311	BANP	Homo sapiens	Q8N9N5-2	Y2H Array	32296183
Intra	CDC7	O00311	ZBTB10	Homo sapiens	Q96DT7-3	Validated Y2H	32296183
Intra	CDC7	O00311	ZBTB10	Homo sapiens	Q96DT7-3	Y2H Array	32296183
Intra	CDC7	O00311	ZBTB10	Homo sapiens	Q96DT7-3	Y2H Prey Pooling	32296183
Intra	CDC7	O00311	LZTS1	Homo sapiens	Q9Y250	Y2H Prey Pooling	32296183
Intra	CDC7	O00311	LZTS1	Homo sapiens	Q9Y250	Validated Y2H	32296183
Intra	CDC7	O00311	LZTS1	Homo sapiens	Q9Y250	Y2H Array	32296183
Intra	CDC7	O00311	WUGSC:H_DJ0726N20.gs.b	Homo sapiens	Q9Y6T4	Validated Y2H	32296183
Intra	CDC7	O00311	IKZF4	Homo sapiens	Q9H2S9	Validated Y2H	32296183
Intra	CDC7	O00311	IKZF4	Homo sapiens	Q9H2S9	Y2H Prey Pooling	32296183
Intra	CDC7	O00311	IKZF4	Homo sapiens	Q9H2S9	Y2H Array	32296183
Intra	CDC7	O00311	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	CDC7	O00311	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	CDC7	O00311	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	CDC7	O00311	ZBTB8B	Homo sapiens	Q8NAP8	Y2H Prey Pooling	32296183
Intra	CDC7	O00311	ZBTB8B	Homo sapiens	Q8NAP8	Validated Y2H	32296183
Intra	CDC7	O00311	ZBTB8B	Homo sapiens	Q8NAP8	Y2H Array	32296183
Intra	CDC7	O00311	TSPY10	Homo sapiens	P0CW01	Y2H Prey Pooling	32296183
Intra	CDC7	O00311	TSPY10	Homo sapiens	P0CW01	Validated Y2H	32296183
Intra	CDC7	O00311	TSPY10	Homo sapiens	P0CW01	Y2H Array	32296183
Intra	CDC7	O00311	HMBOX1	Homo sapiens	Q6NT76	Y2H Prey Pooling	32296183
Intra	CDC7	O00311	HMBOX1	Homo sapiens	Q6NT76	Validated Y2H	32296183
Intra	CDC7	O00311	HMBOX1	Homo sapiens	Q6NT76	Y2H Array	32296183
Intra	CDC7	O00311	SERTAD2	Homo sapiens	Q14140	Y2H Prey Pooling	32296183
Intra	CDC7	O00311	SERTAD2	Homo sapiens	Q14140	Validated Y2H	32296183
Intra	CDC7	O00311	SERTAD2	Homo sapiens	Q14140	Y2H Array	32296183
Intra	CDC7	O00311	DBF4	Homo sapiens	Q9UBU7	Y2H Prey Pooling	32296183
Intra	CDC7	O00311	DBF4	Homo sapiens	Q9UBU7	Validated Y2H	32296183
Intra	CDC7	O00311	DBF4	Homo sapiens	Q9UBU7	Y2H Array	32296183
Intra	CDC7	O00311	DBF4	Homo sapiens	Q9UBU7	GMS	16899510
Intra	CDC7	O00311	DBF4	Homo sapiens	Q9UBU7	Y2H Array	31515488
Intra	CDC7	O00311	DBF4	Homo sapiens	Q9UBU7	Pull Down	32707033
Intra	CDC7	O00311	STAM2	Homo sapiens	O75886	Y2H Prey Pooling	32296183
Intra	CDC7	O00311	STAM2	Homo sapiens	O75886	Validated Y2H	32296183
Intra	CDC7	O00311	STAM2	Homo sapiens	O75886	Y2H Array	32296183
Intra	CDC7	O00311	ZBTB26	Homo sapiens	Q9HCK0	Y2H Array	32296183
Intra	CDC7	O00311	ZBTB26	Homo sapiens	Q9HCK0	Validated Y2H	32296183
Intra	CDC7	O00311	ZBTB26	Homo sapiens	Q9HCK0	Y2H Prey Pooling	32296183
Intra	CDC7	O00311	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	CDC7	O00311	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	CDC7	O00311	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	CDC7	O00311	GOLGA2	Homo sapiens	Q08379	Validated Y2H	32296183
Intra	CDC7	O00311	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	CDC7	O00311	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	CDC7	O00311	TSNAXIP1	Homo sapiens	Q2TAA8	Y2H Prey Pooling	32296183
Intra	CDC7	O00311	TSNAXIP1	Homo sapiens	Q2TAA8	Validated Y2H	32296183
Intra	CDC7	O00311	TSNAXIP1	Homo sapiens	Q2TAA8	Y2H Array	32296183
Intra	CDC7	O00311	TRIM27	Homo sapiens	P14373	Validated Y2H	32296183
Intra	CDC7	O00311	TRIM27	Homo sapiens	P14373	Y2H Array	32296183
Intra	CDC7	O00311	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	32296183
Intra	CDC7	O00311	CALCOCO2	Homo sapiens	Q13137	Y2H Prey Pooling	32296183
Intra	CDC7	O00311	CALCOCO2	Homo sapiens	Q13137	Validated Y2H	32296183
Intra	CDC7	O00311	CALCOCO2	Homo sapiens	Q13137	Y2H Array	32296183
Intra	CDC7	O00311	TRIM37	Homo sapiens	O94972	Validated Y2H	32296183
Intra	CDC7	O00311	TRIM37	Homo sapiens	O94972	Y2H Array	32296183
Intra	CDC7	O00311	TRIM37	Homo sapiens	O94972	Y2H Prey Pooling	32296183
Intra	CDC7	O00311	IKZF3	Homo sapiens	Q9UKT9	Validated Y2H	32296183
Intra	CDC7	O00311	IKZF3	Homo sapiens	Q9UKT9	Y2H Array	32296183
Intra	CDC7	O00311	IKZF3	Homo sapiens	Q9UKT9	Y2H Prey Pooling	32296183
Intra	CDC7	O00311	GMEB2	Homo sapiens	Q9UKD1	Validated Y2H	32296183
Intra	CDC7	O00311	GMEB2	Homo sapiens	Q9UKD1	Y2H Prey Pooling	32296183
Intra	CDC7	O00311	GMEB2	Homo sapiens	Q9UKD1	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Glaucoma, Primary Open Angle

Glaucoma 1, Open Angle, E	Primary Open Angle Glaucoma
POAG	Adult-Onset Primary Open Angle Glaucoma
Chronic Simple Glaucoma	GLC1E
Primary Open Angle Glaucoma 1e	Glaucoma, Open Angle, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-100888	Simurosertib	Inhibitor	99.94%	Phase 2
HY-15260C	XL413 hydrochloride	Inhibitor	/	Phase 2
HY-143430A	(S)-LY3177833 hydrate	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (32)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15260A	XL413 monohydrochloride	Inhibitor	99.72%	Unkown
HY-13461A	PHA-767491 hydrochloride		99.49%	Unkown
HY-133028	CKI-7 free base	Inhibitor	99.80%	Unkown
HY-100023	LY3177833	Inhibitor	99.48%	Unkown
HY-15260	XL413	Inhibitor	99.76%	Unkown
HY-100888A	(R)-Simurosertib		99.58%	Unkown
HY-101523	Cdc7-IN-1	Inhibitor	99.77%	Unkown
HY-130517	Cdc7-IN-5	Inhibitor	96.73%	Unkown
HY-100023A	LY3177833 monhydrate	Inhibitor	99.76%	Unkown
HY-148065	FMF-06-098-1		/	Unkown
HY-13461	PHA-767491	Inhibitor	99.85%	Unkown
HY-130516	Cdc7-IN-4	Inhibitor	/	Unkown
HY-130515	Cdc7-IN-3	Inhibitor	/	Unkown
HY-130519	Cdc7-IN-7	Inhibitor	/	Unkown
HY-117677	Cdc7-IN-21	Inhibitor	/	Unkown
HY-143377	Cdc7-IN-8	Inhibitor	/	Unkown
HY-143380	Cdc7-IN-9	Inhibitor	/	Unkown
HY-143381	Cdc7-IN-10	Inhibitor	/	Unkown
HY-143383	Cdc7-IN-11	Inhibitor	/	Unkown
HY-143385	Cdc7-IN-12	Inhibitor	/	Unkown
HY-143387	Cdc7-IN-13	Inhibitor	/	Unkown
HY-143389	Cdc7-IN-14	Inhibitor	/	Unkown
HY-143429	Cdc7-IN-15	Inhibitor	/	Unkown
HY-143430	(S)-LY3177833	Inhibitor	/	Unkown
HY-143431	Cdc7-IN-17	Inhibitor	/	Unkown
HY-143432	Cdc7-IN-18	Inhibitor	/	Unkown
HY-143432A	(S)-Cdc7-IN-18	Inhibitor	/	Unkown
HY-143433	Cdc7-IN-19	Inhibitor	/	Unkown
HY-162007	PYRA-2	Inhibitor	/	Unkown
HY-163374	Cdc7-IN-20	Inhibitor	/	Unkown
HY-RS02309	CDC7 Human Pre-designed siRNA Set A		/	Unkown
HY-W011109	CKI-7	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CDC7	VGNC	VGNC:80164
Mus musculus	CDC7	MGD	MGI:1309511
Canis familiaris	CDC7	VGNC	VGNC:39010
Macaca mulatta	CDC7	VGNC	VGNC:106340
Rattus norvegicus	CDC7	RGD	RGD:1308351
Bos taurus	CDC7	VGNC	VGNC:27082
Others	CDC7	NCBI

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