STRADB - STE20 related adaptor beta Gene

Homo sapiens

Also known as PAPK; ILPIP; ILPIPA; ALS2CR2; CALS-21; PRO1038

Gene ID: 55437 | Gene type: protein coding

About STRADB

Cytogenetic location: 2q33.1 Genomic coordinates (GRCh38): 2:201,451,740-201,480,846 (from NCBI)

This gene has 10 transcripts (splice variants), 205 orthologues and 35 paralogues. Ubiquitous expression in bone marrow (RPKM 24.2), kidney (RPKM 22.5) and 25 other tissues.

Summary

This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of Apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

STRADB Products(2)

mRNA	Protein	Name
NM_001206864.2	NP_001193793.1	STE20-related kinase adapter protein beta isoform 2
NM_018571.6	NP_061041.2	STE20-related kinase adapter protein beta isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14676191	GOA
NOT enables protein kinase activity	IDA IDA: Inferred from direct assay	14517248	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in activation of protein kinase activity	IDA IDA: Inferred from direct assay	14517248	GOA
involved in protein export from nucleus	IDA IDA: Inferred from direct assay	14517248	GOA
NOT involved in protein phosphorylation	IDA IDA: Inferred from direct assay	14517248	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	14517248	GOA
located in nucleus	IDA IDA: Inferred from direct assay	14517248	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STRADB Protein Structure

Pkinase

0
100
200
300
418 a.a.

Protein Preferred Names

Protein Names

STE20-related kinase adapter protein beta

ILP-interacting protein ILPIPA

STRADB Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	STRADB	Q9C0K7	STK11	Homo sapiens	Q15831	Pull Down	32707033
Intra	STRADB	Q9C0K7	STK11	Homo sapiens	Q15831	IF	14676191
Intra	STRADB	Q9C0K7	STK11	Homo sapiens	Q15831	Anti Tag CoIP	33961781
Intra	STRADB	Q9C0K7	STK11	Homo sapiens	Q15831	Anti Tag CoIP	14676191
Intra	STRADB	Q9C0K7	STK11	Homo sapiens	Q15831	Protein Kinase Assay	14676191
Intra	STRADB	Q9C0K7	CAB39	Homo sapiens	Q9Y376	Anti Tag CoIP	33961781
Intra	STRADB	Q9C0K7	CAB39	Homo sapiens	Q9Y376	Anti Tag CoIP	14676191
Intra	STRADB	Q9C0K7	CAB39	Homo sapiens	Q9Y376	IF	14676191
Intra	STRADB	Q9C0K7	CAB39	Homo sapiens	Q9Y376	Pull Down	32707033
Intra	STRADB	Q9C0K7	CAB39	Homo sapiens	Q9Y376	Y2H Fragment Pooling	23414517

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Amyotrophic Lateral Sclerosis 2, Juvenile

ALS2	Als, Juvenile
Alsj	Amyotrophic Lateral Sclerosis Type 2
Amyotrophic Lateral Sclerosis 2	Amyotrophic Lateral Sclerosis Type 2, Juvenile
Amyotrophic Lateral Sclerosis Juvenile	Amyotrophic Lateral Sclerosis Juvenile 2
Sclerosis, Lateral, Amyotrophic, Type Type 2

Pyelitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13960	STRADB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	STRADB	VGNC	VGNC:46940
Mus musculus	STRADB	MGD	MGI:2144047
Felis catus	STRADB	VGNC	VGNC:80370
Rattus norvegicus	STRADB	RGD	RGD:1559449
Bos taurus	STRADB	VGNC	VGNC:35419
Macaca mulatta	STRADB	VGNC	VGNC:99408

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