2. Gene
  3. CAB39 - calcium binding protein 39 Gene

CAB39 - calcium binding protein 39 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MO25; CGI-66

Gene ID: 51719 | Gene type: protein coding

About CAB39

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:230,712,842-230,821,075 (from NCBI)

This gene has 6 transcripts (splice variants), 139 orthologues and 1 paralogue. Ubiquitous expression in colon (RPKM 18.8), appendix (RPKM 18.4) and 25 other tissues.

Summary

Enables kinase binding activity and protein serine/threonine kinase activator activity. Involved in intracellular signal transduction; peptidyl-serine phosphorylation; and positive regulation of protein phosphorylation. Located in extracellular exosome. Implicated in hepatocellular carcinoma. Biomarker of hepatocellular carcinoma and pancreatic Cancer. [provided by Alliance of Genome Resources, Apr 2022]

CAB39 Products(3)

mRNA Protein Name
NM_001130849.2 NP_001124321.1 calcium-binding protein 39
NM_001130850.2 NP_001124322.1 calcium-binding protein 39
NM_016289.4 NP_057373.1 calcium-binding protein 39
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables kinase binding IPI
IPI: Inferred from physical interaction
19892943 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
14676191 GOA
enables protein kinase activator activity IDA
IDA: Inferred from direct assay
19892943 GOA
enables protein serine/threonine kinase activator activity IDA
IDA: Inferred from direct assay
19892943 GOA
Biological Process GO Annotation Evidence Reference Source
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
24393035 GOA
involved in peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
24393035 GOA
involved in positive regulation of peptidyl-threonine phosphorylation IDA
IDA: Inferred from direct assay
24393035 GOA
involved in positive regulation of protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
19892943 GOA
involved in signal transduction IDA
IDA: Inferred from direct assay
24393035 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
14517248 GOA
part of serine/threonine protein kinase complex IPI
IPI: Inferred from physical interaction
19892943 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CAB39 Protein Structure

Mo25

Mo25: Mo25-like (1 - 334)

  • 0
  • 100
  • 200
  • 300
  • 341 a.a.
Protein Preferred Names Protein Names

calcium-binding protein 39

MO25alpha

CAB39 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CAB39 Q9Y376 STK24 Homo sapiens Q9Y6E0-2
Validated Y2H
32296183
Intra
CAB39 Q9Y376 STK24 Homo sapiens Q9Y6E0-2
Y2H Array
32296183
Intra
CAB39 Q9Y376 STK24 Homo sapiens Q9Y6E0-2
Y2H Prey Pooling
32296183
Intra
CAB39 Q9Y376 STRADA Homo sapiens Q7RTN6
Anti Tag CoIP
21423148
Intra
CAB39 Q9Y376 STRADA Homo sapiens Q7RTN6
Anti Tag CoIP
33961781
Intra
CAB39 Q9Y376 MCCD1 Homo sapiens P59942
Y2H Array
32296183
Intra
CAB39 Q9Y376 MCCD1 Homo sapiens P59942
Y2H Prey Pooling
32296183
Intra
CAB39 Q9Y376 STRADA Homo sapiens Q7RTN6-1
Anti Bait CoIP
26479318
Intra
CAB39 Q9Y376 STK26 Homo sapiens Q9P289-1
Comigration in SDS
23434407
Intra
CAB39 Q9Y376 STK26 Homo sapiens Q9P289-1
Anti Tag CoIP
23434407
Intra
CAB39 Q9Y376 STK26 Homo sapiens Q9P289-1
BLI
23434407
Intra
CAB39 Q9Y376 STK26 Homo sapiens Q9P289-1
X-Ray Diffraction
23434407
Intra
CAB39 Q9Y376 STK26 Homo sapiens Q9P289-1
GMS
23434407
Intra
CAB39 Q9Y376 STK39 Homo sapiens Q9UEW8
Anti Tag CoIP
21423148
Intra
CAB39 Q9Y376 STK39 Homo sapiens Q9UEW8
SPR
21423148
Intra
CAB39 Q9Y376 STK11 Homo sapiens Q15831
Anti Tag CoIP
33961781
Intra
CAB39 Q9Y376 STK11 Homo sapiens Q15831
Affinity Chrom
15733851
Intra
CAB39 Q9Y376 STK11 Homo sapiens Q15831
Anti Bait CoIP
26479318
Intra
CAB39 Q9Y376 STK11 Homo sapiens Q15831
Anti Tag CoIP
14676191
Intra
CAB39 Q9Y376 STK11 Homo sapiens Q15831
PLA
25241761
Intra
CAB39 Q9Y376 STRADB Homo sapiens Q9C0K7
Y2H Fragment Pooling
23414517
Intra
CAB39 Q9Y376 STRADB Homo sapiens Q9C0K7
Anti Tag CoIP
14676191
Intra
CAB39 Q9Y376 MED7 Homo sapiens O43513
Y2H Array
32296183
Intra
CAB39 Q9Y376 MED7 Homo sapiens O43513
Y2H Prey Pooling
32296183
Intra
CAB39 Q9Y376 STK26 Homo sapiens Q9P289
Anti Tag CoIP
21423148
Intra
CAB39 Q9Y376 STK26 Homo sapiens Q9P289
SPR
21423148
Intra
CAB39 Q9Y376 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
CAB39 Q9Y376 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
CAB39 Q9Y376 OXSR1 Homo sapiens O95747
SPR
21423148
Intra
CAB39 Q9Y376 CEP44 Homo sapiens Q9C0F1
Y2H Prey Pooling
32296183
Intra
CAB39 Q9Y376 CEP44 Homo sapiens Q9C0F1
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

CAB39 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83016 CAB39 Antibody (YA2761) WB, IHC-P, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01778 CAB39 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01779 CAB39L Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CAB39 VGNC VGNC:60281
Canis familiaris CAB39 VGNC VGNC:38619
Mus musculus CAB39 MGD MGI:107438
Bos taurus CAB39 VGNC VGNC:26661
Rattus norvegicus CAB39 RGD RGD:1306390
Macaca mulatta CAB39 VGNC VGNC:70590
Others CAB39 NCBI