2. Gene
  3. TRIM36 - tripartite motif containing 36 Gene

TRIM36 - tripartite motif containing 36 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ANPH; ANPH1; RNF98; HAPRIN; RBCC728

Gene ID: 55521 | Gene type: protein coding

About TRIM36

Cytogenetic location: 5q22.3 Genomic coordinates (GRCh38): 5:115,124,772-115,180,294 (from NCBI)

This gene has 10 transcripts (splice variants), 209 orthologues, 80 paralogues and is associated with 1 phenotype. Biased expression in testis (RPKM 36.6), brain (RPKM 4.1) and 4 other tissues.

Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

TRIM36 Products(5)

mRNA Protein Name
NM_001017397.2 NP_001017397.1 E3 ubiquitin-protein ligase TRIM36 isoform 2
NM_001017398.2 NP_001017398.1 E3 ubiquitin-protein ligase TRIM36 isoform 3
NM_001300752.2 NP_001287681.1 E3 ubiquitin-protein ligase TRIM36 isoform 4
NM_001300759.2 NP_001287688.1 E3 ubiquitin-protein ligase TRIM36 isoform 5
NM_018700.4 NP_061170.2 E3 ubiquitin-protein ligase TRIM36 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence Reference Source
involved in mitotic cytokinesis IMP
IMP: Inferred from mutant phenotype
28087737 GOA
involved in regulation of microtubule cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
28087737 GOA
involved in spindle organization IMP
IMP: Inferred from mutant phenotype
28087737 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
28087737 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM36 Protein Structure

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (33 - 61)

zf-B_box

zf-B_box: B-box zinc finger (210 - 248)

fn3

fn3: Fibronectin type III domain (431 - 494)

SPRY

SPRY: SPRY domain (571 - 710)

  • 0
  • 200
  • 400
  • 600
  • 728 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase TRIM36

RING finger protein 98

TRIM36 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
TRIM36 Q9NQ86 EIF4A2 Homo sapiens Q14240-2
Validated Y2H
25416956
Intra
TRIM36 Q9NQ86 EIF4A2 Homo sapiens Q14240-2
Y2H Array
25416956
Intra
TRIM36 Q9NQ86 ZMAT2 Homo sapiens Q96NC0
Y2H Prey Pooling
25416956
Intra
TRIM36 Q9NQ86 ZMAT2 Homo sapiens Q96NC0
Validated Y2H
25416956
Intra
TRIM36 Q9NQ86 BTRC Homo sapiens Q9Y297
Y2H Prey Pooling
32296183
Intra
TRIM36 Q9NQ86 BTRC Homo sapiens Q9Y297
Validated Y2H
32296183
Intra
TRIM36 Q9NQ86 BTRC Homo sapiens Q9Y297
Y2H Array
32296183
Intra
TRIM36 Q9NQ86 GLRX3 Homo sapiens O76003
Y2H Prey Pooling
32296183
Intra
TRIM36 Q9NQ86 GLRX3 Homo sapiens O76003
Y2H Prey Pooling
25416956
Intra
TRIM36 Q9NQ86 GLRX3 Homo sapiens O76003
Y2H Array
32296183
Intra
TRIM36 Q9NQ86 EIF4A2 Homo sapiens Q14240
Y2H Prey Pooling
25416956
Intra
TRIM36 Q9NQ86 ZNF417 Homo sapiens Q8TAU3
Y2H Array
25416956
Intra
TRIM36 Q9NQ86 TRAF3IP3 Homo sapiens Q9Y228
Y2H Prey Pooling
25416956
Intra
TRIM36 Q9NQ86 TRAF3IP3 Homo sapiens Q9Y228
Validated Y2H
25416956
Intra
TRIM36 Q9NQ86 TRAF3IP3 Homo sapiens Q9Y228
Y2H Array
25416956
Intra
TRIM36 Q9NQ86 GRB7 Homo sapiens Q14451
Y2H Prey Pooling
25416956
Intra
TRIM36 Q9NQ86 GRB7 Homo sapiens Q14451
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Anencephaly 1

ANPH1

Anph

Isolated Anencephaly/Exencephaly

Anencephalus
Anencephaly

Aprosencephaly

Anencephalus

Congenital Absence Of Brain

Absence Of A Large Part Of The Brain And The Skull

Anencephalia

Anencephalic Monster

Brain Absence

Brain Agenesis

Brain Aplasia

Absent Brain

Anencephalic

Congenital Absence Of Cerebrum

Congenital Hemicrania

Incomplete Anencephaly
Non-Syndromic X-Linked Intellectual Disability 101

Mrx101

X-Linked Mental Retardation 101
Syndromic X-Linked Intellectual Disability Cabezas Type

Cabezas Syndrome

Syndromic X-Linked Mental Retardation 15

Mental Retardation, X-Linked, Syndromic 15

Mrss

Mrxs15

Mrxsc

X-Linked Mental Retardation With Short Stature

X-Linked Mental Retardation With Short Stature, Hypogonadism, And Abnormal Gait

Mental Retardation, X-Linked, With Short Stature

Mental Retardation, X-Linked, With Short Stature, Hypogonadism, And Abnormal Gait
Neuronopathy, Distal Hereditary Motor, Type Iid

HMN2D

Hmn Iid

Dhmn2d

Distal Hereditary Motor Neuronopathy Type 2d

Distal Hereditary Motor Neuropathy Type Iid

Neuronopathy, Distal Hereditary Motor, Type 2d

Neuropathy, Distal Hereditary Motor, Type Iid

Spinal Muscular Atrophy, Distal, Autosomal Dominant, Calf-Predominant

Distal Spinal Muscular Atrophy With Calf Predominance

Neuronopathy, Distal Hereditary Motor, 2d

Autosomal Dominant Spinal Muscular Atrophy Distal Calf-Predominant

Dhmn Iid

Neuropathy, Motor, Distal, Hereditary, Type 2d
Gait Apraxia
Distal Hereditary Motor Neuronopathy Type 2

Distal Hereditary Motor Neuropathy, Type Ii

Distal Hereditary Motor Neuropathy Type 2

Distal Hereditary Motor Neuropathy Type Ii

Hmn Ii

Hmn2

Distal Hereditary Motor Neuronopathy, Type Ii

Distal Spinal Muscular Atrophy Type 2

Dhmn2

Dsma2

Neuropathy, Motor, Distal, Hereditary, Type Ii

Spinal Muscular Atrophy, Jerash Type
Non-Syndromic X-Linked Intellectual Disability

X-Linked Non-Syndromic Intellectual Disability

Non-Specific X-Linked Mental Retardation

X-Linked Non-Specific Intellectual Disability
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15040 TRIM36 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TRIM36 MGD MGI:106264
Macaca mulatta TRIM36 VGNC VGNC:79023
Felis catus TRIM36 VGNC VGNC:66536
Canis familiaris TRIM36 VGNC VGNC:47817
Rattus norvegicus TRIM36 RGD RGD:1308714
Bos taurus TRIM36 VGNC VGNC:36331