ZMAT2 - zinc finger matrin-type 2 Gene

Homo sapiens

Also known as Snu23; Ptg-12

Gene ID: 153527 | Gene type: protein coding

About ZMAT2

Cytogenetic location: 5q31.3 Genomic coordinates (GRCh38): 5:140,700,447-140,706,686 (from NCBI)

This gene has 3 transcripts (splice variants), 210 orthologues and 9 paralogues. Ubiquitous expression in brain (RPKM 45.9), fat (RPKM 34.0) and 25 other tissues.

Summary

Predicted to enable DNA binding activity and zinc ion binding activity. Involved in mRNA splicing, via spliceosome. Located in nucleus. Part of U2-type precatalytic spliceosome. [provided by Alliance of Genome Resources, Apr 2022]

ZMAT2 Products(1)

mRNA	Protein	Name
NM_144723.3	NP_653324.1	zinc finger matrin-type protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20195357	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	28781166	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of U2-type precatalytic spliceosome	IDA IDA: Inferred from direct assay	28781166	GOA
located in nucleus	IDA IDA: Inferred from direct assay	28781166	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZMAT2 Protein Structure

zf-C2H2_jaz

0
100
199 a.a.

Protein Preferred Names

Protein Names

zinc finger matrin-type protein 2

ZMAT2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZMAT2	Q96NC0	KRT40	Homo sapiens	Q6A162	Y2H Array	25416956
Intra	ZMAT2	Q96NC0	ZBTB14	Homo sapiens	O43829	Validated Y2H	25416956
Intra	ZMAT2	Q96NC0	FXR1	Homo sapiens	P51114-2	Y2H Array	32296183
Intra	ZMAT2	Q96NC0	FXR1	Homo sapiens	P51114-2	Y2H Prey Pooling	32296183
Intra	ZMAT2	Q96NC0	PSEN1	Homo sapiens	P49768-2	Y2H Array	32814053
Intra	ZMAT2	Q96NC0	PSEN1	Homo sapiens	P49768-2	Validated Y2H	32814053
Intra	ZMAT2	Q96NC0	PSEN1	Homo sapiens	P49768-2	Y2H Pooling	32814053
Intra	ZMAT2	Q96NC0	TFIP11	Homo sapiens	Q9UBB9	Y2H Prey Pooling	25416956
Intra	ZMAT2	Q96NC0	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	31515488
Intra	ZMAT2	Q96NC0	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	32296183
Intra	ZMAT2	Q96NC0	MTUS2	Homo sapiens	Q5JR59-3	Y2H Prey Pooling	32296183
Intra	ZMAT2	Q96NC0	CDR2	Homo sapiens	Q01850	Y2H Prey Pooling	32296183
Intra	ZMAT2	Q96NC0	CDR2	Homo sapiens	Q01850	Y2H Array	32296183
Intra	ZMAT2	Q96NC0	BICD2	Homo sapiens	Q8TD16-2	Y2H Prey Pooling	32296183
Intra	ZMAT2	Q96NC0	BICD2	Homo sapiens	Q8TD16-2	Y2H Array	32296183
Intra	ZMAT2	Q96NC0	PSEN2	Homo sapiens	P49810	Y2H Pooling	32814053
Intra	ZMAT2	Q96NC0	PSEN2	Homo sapiens	P49810	Validated Y2H	32814053
Intra	ZMAT2	Q96NC0	PSEN2	Homo sapiens	P49810	Y2H Array	32814053
Intra	ZMAT2	Q96NC0	APBB2	Homo sapiens	Q92870-2	Validated Y2H	32814053
Intra	ZMAT2	Q96NC0	APBB2	Homo sapiens	Q92870-2	Y2H Array	32814053
Intra	ZMAT2	Q96NC0	APBB2	Homo sapiens	Q92870-2	Y2H Pooling	32814053
Intra	ZMAT2	Q96NC0	TRIM36	Homo sapiens	Q9NQ86	Y2H Array	25416956
Intra	ZMAT2	Q96NC0	HMBOX1	Homo sapiens	Q6NT76	Validated Y2H	25416956
Intra	ZMAT2	Q96NC0	KANK2	Homo sapiens	Q63ZY3	Y2H Prey Pooling	32296183
Intra	ZMAT2	Q96NC0	KANK2	Homo sapiens	Q63ZY3	Y2H Array	32296183
Intra	ZMAT2	Q96NC0	VPS52	Homo sapiens	Q8N1B4	Y2H Prey Pooling	25416956
Intra	ZMAT2	Q96NC0	VPS52	Homo sapiens	Q8N1B4	Validated Y2H	25416956
Intra	ZMAT2	Q96NC0	CCDC57	Homo sapiens	Q2TAC2	Y2H Prey Pooling	25416956
Intra	ZMAT2	Q96NC0	CCDC57	Homo sapiens	Q2TAC2	Y2H Array	25416956
Intra	ZMAT2	Q96NC0	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
Intra	ZMAT2	Q96NC0	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
Intra	ZMAT2	Q96NC0	TRAF2	Homo sapiens	Q12933	Y2H Array	25416956
Intra	ZMAT2	Q96NC0	TRAF2	Homo sapiens	Q12933	Validated Y2H	25416956
Intra	ZMAT2	Q96NC0	TNIP1	Homo sapiens	Q15025	Y2H Array	32296183
Intra	ZMAT2	Q96NC0	TNIP1	Homo sapiens	Q15025	Y2H Prey Pooling	32296183
Intra	ZMAT2	Q96NC0	SPAG5	Homo sapiens	Q96R06	Y2H Array	25416956
Intra	ZMAT2	Q96NC0	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	ZMAT2	Q96NC0	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	ZMAT2	Q96NC0	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	ZMAT2	Q96NC0	FSD2	Homo sapiens	A1L4K1	Validated Y2H	25416956
Intra	ZMAT2	Q96NC0	FSD2	Homo sapiens	A1L4K1	Y2H Prey Pooling	25416956
Intra	ZMAT2	Q96NC0	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Intra	ZMAT2	Q96NC0	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
Intra	ZMAT2	Q96NC0	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	ZMAT2	Q96NC0	GOLGA2	Homo sapiens	Q08379	Y2H Array	25416956
Intra	ZMAT2	Q96NC0	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	ZMAT2	Q96NC0	HAP1	Homo sapiens	P54257	Y2H Prey Pooling	32296183
Intra	ZMAT2	Q96NC0	HAP1	Homo sapiens	P54257	Y2H Array	32296183
Intra	ZMAT2	Q96NC0	PHC2	Homo sapiens	Q8IXK0	Y2H Array	25416956
Intra	ZMAT2	Q96NC0	PHC2	Homo sapiens	Q8IXK0	Y2H Prey Pooling	25416956
Intra	ZMAT2	Q96NC0	NDRG1	Homo sapiens	Q92597	Validated Y2H	32814053
Intra	ZMAT2	Q96NC0	NDRG1	Homo sapiens	Q92597	Y2H Array	32814053
Intra	ZMAT2	Q96NC0	NDRG1	Homo sapiens	Q92597	Y2H Pooling	32814053
Intra	ZMAT2	Q96NC0	GRIPAP1	Homo sapiens	Q4V328	Y2H Prey Pooling	32296183
Intra	ZMAT2	Q96NC0	GRIPAP1	Homo sapiens	Q4V328	Y2H Array	32296183
Intra	ZMAT2	Q96NC0	FXR2	Homo sapiens	P51116	Y2H Prey Pooling	32296183
Intra	ZMAT2	Q96NC0	FXR2	Homo sapiens	P51116	Y2H Array	32296183
Intra	ZMAT2	Q96NC0	LZTS2	Homo sapiens	Q9BRK4	Y2H Prey Pooling	25416956
Intra	ZMAT2	Q96NC0	TRIM37	Homo sapiens	O94972	Validated Y2H	25416956
Intra	ZMAT2	Q96NC0	TRIM37	Homo sapiens	O94972	Y2H Array	25416956
Intra	ZMAT2	Q96NC0	ZBTB8A	Homo sapiens	Q96BR9	Y2H Prey Pooling	25416956
Intra	ZMAT2	Q96NC0	CEP76	Homo sapiens	Q8TAP6	Y2H Prey Pooling	25416956
Intra	ZMAT2	Q96NC0	MTUS2	Homo sapiens	Q5JR59	Y2H Prey Pooling	25416956
Intra	ZMAT2	Q96NC0	IKZF1	Homo sapiens	Q13422	Y2H Prey Pooling	25416956
Intra	ZMAT2	Q96NC0	IKZF1	Homo sapiens	Q13422	Validated Y2H	25416956
Intra	ZMAT2	Q96NC0	MEOX2	Homo sapiens	P50222	Y2H Prey Pooling	25416956
Intra	ZMAT2	Q96NC0	MEOX2	Homo sapiens	P50222	Validated Y2H	25416956
Intra	ZMAT2	Q96NC0	OPTN	Homo sapiens	Q96CV9	Display Tech	20195357
Intra	ZMAT2	Q96NC0	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32814053
Intra	ZMAT2	Q96NC0	OPTN	Homo sapiens	Q96CV9	Y2H Pooling	32814053
Intra	ZMAT2	Q96NC0	OPTN	Homo sapiens	Q96CV9	Y2H Array	32814053
Intra	ZMAT2	Q96NC0	CALCOCO1	Homo sapiens	Q9P1Z2	Y2H Prey Pooling	32296183
Intra	ZMAT2	Q96NC0	CALCOCO1	Homo sapiens	Q9P1Z2	Validated Y2H	32296183
Intra	ZMAT2	Q96NC0	CALCOCO1	Homo sapiens	Q9P1Z2	Y2H Array	32296183
Intra	ZMAT2	Q96NC0	PRPH	Homo sapiens	P41219	Y2H Prey Pooling	32296183
Intra	ZMAT2	Q96NC0	PRPH	Homo sapiens	P41219	Y2H Array	32296183
Intra	ZMAT2	Q96NC0	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	ZMAT2	Q96NC0	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	ZMAT2	Q96NC0	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	ZMAT2	Q96NC0	AK8	Homo sapiens	Q96MA6	Y2H Array	25416956
Intra	ZMAT2	Q96NC0	AK8	Homo sapiens	Q96MA6	Y2H Prey Pooling	25416956
Intra	ZMAT2	Q96NC0	NAB2	Homo sapiens	Q15742	Y2H Prey Pooling	32296183
Intra	ZMAT2	Q96NC0	NAB2	Homo sapiens	Q15742	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Radioulnar Synostosis

Radio-Ulnar Synostosis Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16084	ZMAT2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ZMAT2	MGD	MGI:1913742
Rattus norvegicus	ZMAT2	RGD	RGD:1583592
Macaca mulatta	ZMAT2	VGNC	VGNC:79610
Canis familiaris	ZMAT2	VGNC	VGNC:48639
Bos taurus	ZMAT2	VGNC	VGNC:37191
Felis catus	ZMAT2	VGNC	VGNC:67252

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