MAPK13 - mitogen-activated protein kinase 13 Gene

Homo sapiens

Also known as SAPK4; PRKM13; MAPK 13; MAPK-13; p38delta

Gene ID: 5603 | Gene type: protein coding

About MAPK13

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:36,130,513-36,144,521 (from NCBI)

This gene has 5 transcripts (splice variants), 214 orthologues and 19 paralogues. Broad expression in skin (RPKM 21.7), small intestine (RPKM 17.1) and 22 other tissues.

Summary

This gene encodes a member of the mitogen-activated protein (MAP) kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The encoded protein is a p38 MAP kinase and is activated by proinflammatory cytokines and cellular stress. Substrates of the encoded protein include the transcription factor ATF2 and the microtubule dynamics regulator stathmin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]

MAPK13 Products(2)

mRNA	Protein	Name
NR_072996.2
NM_002754.5	NP_002745.1	mitogen-activated protein kinase 13

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables MAP kinase activity	IDA IDA: Inferred from direct assay	9218798	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19135240	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	12244047	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to UV	IDA IDA: Inferred from direct assay	9218798	GOA
involved in cellular response to anisomycin	IDA IDA: Inferred from direct assay	9218798	GOA
involved in cellular response to hydrogen peroxide	IDA IDA: Inferred from direct assay	9218798	GOA
involved in cellular response to interleukin-1	IDA IDA: Inferred from direct assay	9218798	GOA
involved in cellular response to sodium arsenite	IDA IDA: Inferred from direct assay	9218798	GOA
involved in cellular response to sorbitol	IDA IDA: Inferred from direct assay	9218798	GOA
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	15850461	GOA
involved in positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	19279008	GOA
involved in response to osmotic stress	IDA IDA: Inferred from direct assay	9731215	GOA
involved in stress-activated MAPK cascade	IDA IDA: Inferred from direct assay	9218798	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAPK13 Protein Structure

Pkinase

0
100
200
300
365 a.a.

Protein Preferred Names

Protein Names

mitogen-activated protein kinase 13

MAP kinase 13	MAP kinase p38 delta
mitogen-activated protein kinase p38 delta	stress-activated protein kinase 4

MAPK13 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MAPK13	O15264	PRKD1	Homo sapiens	Q15139	Anti Tag CoIP	19135240
Intra	MAPK13	O15264	PRKD1	Homo sapiens	Q15139	Protein Kinase Assay	19135240
Intra	MAPK13	O15264	FPR1	Homo sapiens	P21462	Anti Bait CoIP	22447027
Intra	MAPK13	O15264	POTEF	Homo sapiens	A5A3E0	Anti Tag CoIP	28514442
Intra	MAPK13	O15264	POTEF	Homo sapiens	A5A3E0	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MAPK13 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73334	p38 delta/MAPK13 Protein, Human (sf9, GST)	O15264-1 (M1-L365)	≥95%

Related Diseases

Diseases

Alias

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18850	MAPK13-IN-1	Inhibitor	98.93%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MAPK13	VGNC	VGNC:42994
Mus musculus	MAPK13	MGD	MGI:1346864
Rattus norvegicus	MAPK13	RGD	RGD:3045
Macaca mulatta	MAPK13	VGNC	VGNC:74644
Felis catus	MAPK13	VGNC	VGNC:68166
Bos taurus	MAPK13	VGNC	VGNC:50213
Others	MAPK13	NCBI

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