PRKX - protein kinase cAMP-dependent X-linked catalytic subunit Gene

Homo sapiens

Also known as PKX1

Gene ID: 5613 | Gene type: protein coding

About PRKX

Cytogenetic location: Xp22.33 Genomic coordinates (GRCh38): X:3,604,340-3,713,649 (from NCBI)

This gene has 4 transcripts (splice variants), 193 orthologues and 5 paralogues. Broad expression in thyroid (RPKM 22.9), kidney (RPKM 7.3) and 20 other tissues.

Summary

This gene encodes a serine threonine protein kinase that has similarity to the catalytic subunit of cyclic AMP dependent protein kinases. The encoded protein is developmentally regulated and may be involved in renal epithelial morphogenesis. This protein may also be involved in macrophage and granulocyte maturation. Abnormal recombination between this gene and a related pseudogene on chromosome Y is a frequent cause of sex reversal disorder in XX males and XY females. Pseudogenes of this gene are found on chromosomes X, 15 and Y. [provided by RefSeq, Feb 2010]

PRKX Products(1)

mRNA	Protein	Name
NM_005044.5	NP_005035.1	cAMP-dependent protein kinase catalytic subunit PRKX

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cAMP-dependent protein kinase activity	IDA IDA: Inferred from direct assay	10026146	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16491121	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in angiogenesis	IMP IMP: Inferred from mutant phenotype	21684272	GOA
involved in cell adhesion	IMP IMP: Inferred from mutant phenotype	21684272	GOA
involved in cell-substrate adhesion	IMP IMP: Inferred from mutant phenotype	16491121	GOA
involved in endothelial cell migration	IMP IMP: Inferred from mutant phenotype	21684272	GOA
involved in endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	21684272	GOA
involved in epithelial tube morphogenesis	IDA IDA: Inferred from direct assay	17980165	GOA
involved in kidney morphogenesis	IDA IDA: Inferred from direct assay	17980165	GOA
involved in myeloid cell differentiation	IDA IDA: Inferred from direct assay	9860982	GOA
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	16491121	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	10026146	GOA
involved in regulation of cell adhesion	IDA IDA: Inferred from direct assay	17980165	GOA
involved in regulation of cell migration	IDA IDA: Inferred from direct assay	17980165	GOA
involved in regulation of epithelial cell differentiation involved in kidney development	IDA IDA: Inferred from direct assay	17980165	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10026146	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10026146	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRKX Protein Structure

Pkinase

0
100
200
300
358 a.a.

Protein Preferred Names

Protein Names

cAMP-dependent protein kinase catalytic subunit PRKX

protein kinase PKX1

PRKX Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PRKX	P51817	HSP90AB1	Homo sapiens	P08238	Pull Down	32707033
Intra	PRKX	P51817	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	22939624
Intra	PRKX	P51817	PRKAR1A	Homo sapiens	P10644	Y2H	16491121
Intra	PRKX	P51817	PRKAR1A	Homo sapiens	P10644	Anti Tag CoIP	16491121
Intra	PRKX	P51817	GPKOW	Homo sapiens	Q92917	Anti Tag CoIP	16491121
Intra	PRKX	P51817	SMAD6	Homo sapiens	O43541	Anti Bait CoIP	16491121
Intra	PRKX	P51817	SMAD6	Homo sapiens	O43541	Protein Kinase Assay	16491121
Intra	PRKX	P51817	SMAD6	Homo sapiens	O43541	Y2H	16491121
Intra	PRKX	P51817	SMAD6	Homo sapiens	O43541	Anti Tag CoIP	16491121

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Asbestos-Related Lung Carcinoma

Breast Ductal Adenoma

Primary Pigmented Nodular Adrenocortical Disease

Ppnad	Primary Pigmented Nodular Adrenal Dysplasia
Pigmented Nodular Adrenocortical Disease, Primary, 2	Pigmented Nodular Adrenocortical Disease, Primary, 1

Acth-Independent Macronodular Adrenal Hyperplasia

Acth-Independent Macronodular Adrenocortical Hyperplasia	Adrenocorticotropic Hormone-Independent Macronodular Adrenal Hyperplasia
Corticotropin-Independent Macronodular Adrenal Hyperplasia	Cushing Syndrome Due To Macronodular Adrenal Hyperplasia
AIMAH1	Aimah
Massive Macronodular Adrenocortical Disease	Mmad
Primary Macronodular Adrenal Hyperplasia	Cushing Syndrome, Adrenal, Due To Aimah
Primary Bilateral Macronodular Adrenal Hyperplasia	Acth-Independent Macronodular Adrenal Hyperplasia 1
Acth-Independent Cushing Syndrome	Adrenal Cushing Syndrome Due To Aimah
Acth-Independent Macronodular Adrenal Hyperplasia 2

Polycystic Kidney Disease

Polycystic Kidney Diseases	Pkd
Polycystic Renal Disease	Kidney Disease, Polycystic
Polycystic Kidney, Autosomal Dominant

Carney Complex Variant

Carney Complex	Carney Syndrome
Carney Complex, Type 1	Lamb Syndrome
Name Syndrome	Myxoma-Spotty Pigmentation-Endocrine Overactivity Syndrome
Carney Complex - Trismus - Pseudocamptodactyly Syndrome	Carney Complex, Type 2
Car	Cnc1
Carney Myxoma-Endocrine Complex	Myxoma - Spotty Pigmentation - Endocrine Overactivity
Myxoma, Spotty Pigmentation, And Endocrine Overactivity	Lamb - Lentigines, Atrial Myxoma, Mucocutaneous Myoma, Blue Nevus Syndrome
Name - Nevi, Atrial Myxoma, Skin Myxoma, Ephelides Syndrome	Carney Complex-Trismus-Pseudocamptodactyly Syndrome
CACOV

Fibrolamellar Carcinoma

Fibrolamellar Hepatocellular Carcinoma	Fhcc
Fibrolamellar Hepatocarcinoma	Hepatocellular Carcinoma, Fibrolamellar
Oncocytic Hepatocellular Tumor	Eosinophilic Glassy Cell Hepatoma
Eosinophilic Hepatocellular Carcinoma With Lamellar Fibrosis	Fl-Hcc
Fibrolamellar Oncocytic Hepatoma	Hepatocellular Carcinoma With Increased Stromal Fibrosis
Polygonal Cell Hepatocellular Carcinoma With Fibrous Stroma

Breast Adenoma

Ademoma - Breast

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11159	PRKX Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PRKX	MGD	MGI:1309999
Rattus norvegicus	PRKX	RGD	RGD:1564076
Canis familiaris	PRKX	VGNC	VGNC:54833
Others	PRKX	NCBI

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