1. Gene
  2. IRF3 - interferon regulatory factor 3 Gene

IRF3 - interferon regulatory factor 3 Gene

Homo sapiens

Also known as IIAE7

Gene ID: 3661 | Gene type: protein coding

About IRF3

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,659,572-49,665,857 (from NCBI)

This gene has 31 transcripts (splice variants), 200 orthologues, 8 paralogues and is associated with 1 phenotype. Ubiquitous expression in spleen (RPKM 23.8), lymph node (RPKM 21.2) and 25 other tissues.

Summary

This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. The protein plays an important role in the innate immune response against DNA and RNA viruses. Mutations in this gene are associated with Encephalopathy, acute, infection-induced, herpes-specific, 7. [provided by RefSeq, Sep 2020]

IRF3 Products(8)

mRNA Protein Name
NM_001197122.2 NP_001184051.1 interferon regulatory factor 3 isoform 2
NM_001197123.2 NP_001184052.1 interferon regulatory factor 3 isoform 3
NM_001197124.2 NP_001184053.1 interferon regulatory factor 3 isoform 4
NM_001197125.2 NP_001184054.1 interferon regulatory factor 3 isoform 5
NM_001197126.2 NP_001184055.1 interferon regulatory factor 3 isoform 5
NM_001197127.2 NP_001184056.1 interferon regulatory factor 3 isoform 6
NM_001197128.2 NP_001184057.1 interferon regulatory factor 3 isoform 6
NM_001571.6 NP_001562.1 interferon regulatory factor 3 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA-binding transcription activator activity IDA
IDA: Inferred from direct assay
8524823 GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
17560375 GOA
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
8524823 GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
8524823 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
8524823 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
IMP: Inferred from mutant phenotype
17560375 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
15841462 GOA
enables protein binding IDA
IDA: Inferred from direct assay
10920266 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15841462 GOA
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
11583620 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
22394562 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
12062447 GOA
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
17574024 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence Reference Source
involved in TRIF-dependent toll-like receptor signaling pathway IDA
IDA: Inferred from direct assay
25636800 GOA
involved in antiviral innate immune response IDA
IDA: Inferred from direct assay
9891032 GOA
involved in cellular response to virus IDA
IDA: Inferred from direct assay
25609812 GOA
involved in cytoplasmic pattern recognition receptor signaling pathway IDA
IDA: Inferred from direct assay
8524823 GOA
involved in mRNA transcription IDA
IDA: Inferred from direct assay
9891032 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
8524823 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17560375 GOA
involved in positive regulation of type I interferon production IDA
IDA: Inferred from direct assay
18636090 GOA
involved in regulation of apoptotic process IDA
IDA: Inferred from direct assay
25609812 GOA
involved in toll-like receptor 4 signaling pathway IDA
IDA: Inferred from direct assay
25636800 GOA
Cellular Component GO Annotation Evidence Reference Source
located in chromatin IDA
IDA: Inferred from direct assay
8524823 GOA
is active in cytoplasm IDA
IDA: Inferred from direct assay
9566918 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
17079289 GOA
located in cytoplasm IGI
IGI: Inferred from genetic interaction
23729669 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
25609812 GOA
is active in nucleus IDA
IDA: Inferred from direct assay
10805757 GOA
located in nucleus IDA
IDA: Inferred from direct assay
17079289 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IRF3 Protein Structure

IRF

IRF: Interferon regulatory factor transcription factor (7 - 111)

IRF-3

IRF-3: Interferon-regulatory factor 3 (201 - 379)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 427 a.a.
Protein Preferred Names Protein Names

interferon regulatory factor 3

Related Diseases

Diseases Alias
Encephalopathy, Acute, Infection-Induced 7

IIAE7

Herpes Simplex Encephalitis, Susceptibility To, 5

Encephalopathy, Acute, Infection-Induced , Susceptibility To, 7

Herpes Simplex Encephalitis 5

Encephalopathy, Acute, Infection-Induced, 7, Herpes-Specific

Encephalopathy, Acute, Infection-Induced, 7

Herpes Simplex Encephalitis 7

Hse7

Infection-Induced Acute Encephalopathy 7

Encephalitis, Herpes Simplex, Susceptibility To, Type 5

Encephalopathy, Acute, Infection-Induced 10

Herpes Simplex Encephalitis, Susceptibility To, 7

IIAE10

Encephalopathy, Acute, Infection-Induced , Susceptibility To, 10

Herpes Simplex Encephalitis 7

Encephalitis, Herpes Simplex, Susceptibility To, Type 7

Multisystem Inflammatory Syndrome In Children

Mis-C

Multisystem Inflammatory Disorder In Children And Adolescents

Paediatric Inflammatory Multisystemic Syndrome

Mic

Vaccinia
Viral Infectious Disease

Viral Disease

Arbovirus Infections

Virus Infection

Virus Diseases

Viral Infection

Viral Infections

Virus Infections

Herpes Simplex

Herpes Simplex Infections

Herpesvirus Hominis Disease

Herpes Simplex Disease

Herpesviral Infection Due To Herpes Simplex

Infections Due To Simplex Virus

Herpes Nos

Hepatitis

Chronic Hepatitis

Chronic Persistent Hepatitis

Acute Hepatitis

Hepatitis, Chronic

Acute And Subacute Liver Necrosis

Acute/Subac. Necrosis Of Liver

Animal Hepatitis

Hepatitis Chronic

Hepatitis A

Hepatitis, Animal

Hepatitis Due To Toxoplasmosis

Hepatitis In Toxoplasmosis

Toxoplasmal Hepatitis

Chronic Hepatitis, Unspecified

Chronic Active Hepatitis Nec

Other Specified Chronic Hepatitis

Chronic Persistent Hepatitis Nec

Chronic Lobular Hepatitis Nec

West Nile Virus

West Nile Virus, Susceptibility To

Wnv

Wnv, Susceptibility To

West Nile Viral Infection

Encephalitis, West Nile Fever

West Nile Fever

Measles

Rubeola

Morbilli

Measles Nos

Koplik Spots

Middle East Respiratory Syndrome

Mers

Mers - [Middle East Respiratory Syndrome]

Hepatitis C

Chronic Hepatitis C

Hepatitis C Infection

Hepatitis Nona Nonb

Nanbh

Viral Hepatitis C

Hepatitis C Chronic

Hepatitis C, Chronic

Chronic Type C Viral Hepatitis

Chronic Hcv - [Hepatitis C Virus] Infection

Hepatitis C Nos

Hepatitis C Infection Nos

Hepatitis C-Related Cirrhosis

Type C Viral Hepatitis

Hep C Nos

Sting-Associated Vasculopathy With Onset In Infancy

Savi

Sting-Associated Vasculopathy, Infantile Onset

Sting-Associated Vasculopathy, Infantile-Onset

Covid-19

2019 Novel Coronavirus

2019-Ncov Infection

Covid19

Sars-Cov-2 Infection

Wuhan Coronavirus Infection

Wuhan Seafood Market Pneumonia Virus Infection

Rabies

Lyssa

Hydrophobia

St Hubert Disease

Lymphocytic Choriomeningitis

Lcm

Lymphocytic Meningitis

Lymphocytic Choriomeningitis Virus Encephalomyelitis

Lymphocytic Meningoencephalitis

Non-Arthropod Borne Lymphocytic Choriomeningitis

Lcm - [Lymphocytic Choriomeningitis]

Benign Lymphocytic Meningitis

Meningitis Due To Lymphocytic Choriomeningitis Virus

Severe Acute Respiratory Syndrome

Sars

Sars-Cov Infection

Sars-1

Sar Deficiency

Sars - [Severe Acute Respiratory Syndrome]

Mouth Disease

Mouth Diseases

Mouth Disorders

Hepatitis C Virus

Hepatitis C Virus, Susceptibility To

Hepatitis C Virus Infection, Response To Therapy Of

Hcv

Hcv, Susceptibility To

Hepatitis C Virus, Resistance To

Hepatitis C Virus, Response To Therapy Of

Resistance To Hepatitis C Virus

Bronchiolitis
Newcastle Disease

Newcastle'S Disease

Pseudo-Fowlpest

Oropouche Fever

Oropouche Virus Disease

Oropouche Mosquito-Borne Viral Fever

Microphthalmia With Limb Anomalies

Waardenburg Anophthalmia Syndrome

Ophthalmoacromelic Syndrome

OAS

MLA

Anophthalmia-Syndactyly

Anophthalmia-Syndactyly Syndrome

Anophthalmos With Limb Anomalies

Anophthalmia Waardenburg Syndrome

Anophthalmos-Syndactyly

Ophthalmo-Acromelic Syndrome

Anophthalmia-Waardenburg Syndrome

Anophthalmos-Limb Anomalies Syndrome

Syndactyly-Anophthalmos Syndrome

Microphthalmia, With Limb Anomalies

Chilblain Lupus 1

Chilblain Lupus

CHBL1

Chilblain Lupus Erythematosus

Chle

Hutchinson Lupus

Chilblain Lupus, Type 1

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome

Cree Encephalitis

Aicardi-Goutières Syndrome

Encephalopathy With Basal Ganglia Calcification

Ags

Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid

Pseudotoxoplasmosis Syndrome

Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis

Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis

Aicardi-Goutieres Syndrome 1

Phlebotomus Fever

Pappataci Fever

Sandfly Fever

Sandfly-Borne Phleboviral Disease

Sandfly-Borne Arboviral Fever

Sandfly-Borne Bunyavirus Fever

Three Day Fever

Chitral Fever

Italy Summer Grippe

Italy Summer Grippe Influenza

Cutaneous Lupus Erythematosus

Lupus Erythematosus, Cutaneous

Lupus Erythematosus Cutaneous

Ebola Hemorrhagic Fever

Ebola Virus Disease

Viral Hemorrhagic Fever

Hemorrhagic Fever, Ebola

Ebola

Ehf

Ebola Fever

Hemorrhagic Fevers, Viral

Ebola Haemorrhagic Fever

Ebod - [Ebola Disease]

Evd - [Ebola Virus Disease]

Ebola Virus Haemorrhagic Fever

Vhf - [Viral Haemorrhagic Fever] Nos

Viral Haemorrhagic Fever, Not Otherwise Specified

Argentine Hemorrhagic Fever

Argentinian Hemorrhagic Fever

Junin Hemorrhagic Fever

Hemorrhagic Fever, Argentinian

Ahf - [Argentinian Haemorrhagic Fever]

Argentine Haemorrhagic Fever

Junin Haemorrhagic Fever

Diarrhea

Diarrhoea

Diarrhea Of Presumed Infectious Origin

Burkitt Lymphoma

Burkitt'S Lymphoma

BL

Burkitt Lymphoma, Somatic

Burkitt Lymphoma/Leukaemia

Burkitt'S Tumor

Burkitt'S Tumor Or Lymphoma

Malignant Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma

Burkitt Tumor

Burkitts Lymphoma

Lymphoma, Small Noncleaved-Cell

Burkitt Tumour

Diffuse Small Noncleaved Malignant Burkitt Lymphoma

Malignant Burkitt Lymphoma

“Burkitt-Like” Lymphoma

Undifferentiated Burkitt Lymphoma

Small Noncleaved Cell Burkitt Lymphoma

Lassa Fever

Lf

Lassa Hemorrhagic Fever

Lf - [Lassa Fever]

Monkeypox

Monkeypox Virus Infections

Japanese Encephalitis

Japanese B Encephalitis

Je

Encephalitis Japanese

Encephalitis, Japanese

Russian Autumnal Encephalitis

Je - [Japanese Encephalitis]

Japanese Encephalitis Virus Disease

Jbe - [Japanese B Encephalitis}

B Type Encephalitis

Herpes Simplex Virus Keratitis

Dendritic Keratitis

Keratitis, Dendritic

Keratitis, Herpetic

Human Immunodeficiency Virus Type 1

Aids

Hiv/Aids

Aids, Delayed/Rapid Progression To

Hiv-1, Susceptibility To

Hiv-1 Viremia, Susceptibility To

Human Immunodeficiency Virus Type 1, Susceptibility To

Hiv-1

Aids, Slow Progression To

Rapid Progression To Aids From Hiv1 Infection

Hiv1 Infection, Resistance To

Hiv1 Infection

Hiv-1 Viremia

Aids, Resistance To

Aids, Rapid Progression To

Hiv/Aids, Susceptibility To

Hiv-1, Resistance To

Hiv1, Resistance To

Hiv1

Hiv-1 Disease, Delayed Progression Of

Hiv-1 Disease, Rapid Progression Of

Hiv Infection, Resistance To

Hiv Type 1, Susceptibility To

Hiv Type 1

Hiv-1 Infection

Human Immunodeficiency Virus I Infection

Acquired Immunodeficiency Syndrome

Hiv-Infection/Aids

Viral Encephalitis

Epidemic Encephalitis

Encephalitis Viral

Encephalitis, Arbovirus

Arbovirus Encephalitis

Postviral Encephalitis Nos

Equine Encephalitis

Tick-Borne Encephalitis

Viral Encephalitis Transmitted By Tick

Mosquito-Borne Encephalitis

Acute Haemorrhagic Encephalitis

Acute Idiopathic Encephalitis

Chronic Viral Encephalitis

Endemic Encephalitis

Subacute Viral Encephalitis

Viral Haemorrhagic Encephalitis

Viral Nonepidemic Encephalitis

Nonepidemic Encephalitis

West Nile Fever
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]

Avian Influenza

Bird Flu

Influenza In Birds

Avian Flu

Listeriosis

Listeria Infection

Infection By Listeria Monocytogenes

Listeria Monocytogenes Infection

Listeria Infections

Listerial Foodborne Infection

Circling Disease

Infection Due To Listeria Monocytogenes

Listerellosis

Vasculopathy, Retinal, With Cerebral Leukoencephalopathy And Systemic Manifestations

Retinal Vasculopathy With Cerebral Leukoencephalopathy And Systemic Manifestations

Crv

Rvcl

Rvcl-S

Vasculopathy, Retinal, With Cerebral Leukodystrophy

Retinopathy, Vascular, With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena

Retinal Vasculopathy With Cerebral Leukodystrophy

Retinal Vasculopathy And Cerebral Leukoencephalopathy

Hereditary Vascular Retinopathy

Hvr

RVCLS

Cerebroretinal Vasculopathy, Hereditary

Cerebroretinal Vasculopathy

Herns

Vasculopathy, Retinal, With Cerebral Leukodystrophy, Formerly

Hereditary Cerebroretinal Vasculopathy

Hereditary Endotheliopathy, Retinopathy, Nephropathy, Stroke

Hereditary Systemic Angiopathy

Hsa

Retinal Vasculopathy With Cerebral Leukodystrophy With Systemic Manifestations

Adrvcl

Autosomal Dominant Retinal Vasculopathy With Cerebral Leukodystrophy

Hereditary Endotheliopathy With Retinopathy-Nephropathy-Stroke

Vascular Retinopathy With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena

Human Immunodeficiency Virus Infectious Disease

Hiv Infections

Coronavirus Infectious Disease
Poliomyelitis

Polio

Infantile Paralysis

Immune Deficiency Disease

Immunodeficiency

Primary Immunodeficiency

Primary Immunodeficiency Disease

Immunologic Deficiency Syndromes

Hypoimmunity

Immune Deficiency Disorder

Immunodeficiency Syndrome

Immune Disorder

Primary Immune Deficiency Disorder

Immune System Diseases

Human Immunodeficiency Virus Infection

Hiv - [Human Immunodeficiency Virus Infection]

Hiv Positive Nos

Hiv Disease

Acquired Immune Deficiency Syndrome-Related Complex

Aids-Like Syndrome

Aids-Related Complex Nos

Arc - [Aids-Related Complex]

Immunodeficiency Due To Human Immunodeficiency Virus Infection

Unspecified Human Immunodeficiency Virus Disease

Hiv Disease Nos

Human Immunodeficiency Virus Positive Nos

Hiv Nos

Deficiency Of Complement Initial Pathway

Deficiency Of Complement Terminal Pathway

Cfdd - [Complement Factor D Deficiency]

Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency

Nonfamilial Hypogammaglobulinaemia

Common Variable Immune Deficiency

Nonfamilial Agammaglobulinaemia

Common Variable Agammaglobulinaemia

Agammaglobulinaemia Nos

Agammaglobulinaemia Antibody Deficiency Syndrome

Hypogammaglobulinaemia Antibody Deficiency Syndrome

Acquired Agammaglobulinaemia Nos

Hypogammaglobulinaemia Nos

Hyper Igm

Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia

Noonan Syndrome 1

Noonan Syndrome

NS1

Male Turner Syndrome

Female Pseudo-Turner Syndrome

Turner Phenotype With Normal Karyotype

Noonan Syndrome With Pigmented Villonodular Synovitis

Turner'S Phenotype, Karyotype Normal

Familial Turner Syndrome

Noonan'S Syndrome

Noonan-Ehmke Syndrome

Ns

Pseudo-Ullrich-Turner Syndrome

Turner Syndrome In Female With X Chromosome

Turner-Like Syndrome

Ullrich-Noonan Syndrome

Noonan-Like/Multiple Giant Cell Lesion Syndrome

Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

Pterygium Colli Syndrome

Noonan Syndrome, Type 1

Turner Syndrome, Male

Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus IRF3 VGNC VGNC:67824
Canis familiaris IRF3 VGNC VGNC:54848
Macaca mulatta IRF3 VGNC VGNC:73761
Bos taurus IRF3 VGNC VGNC:30274
Rattus norvegicus IRF3 RGD RGD:1549774
Mus musculus IRF3 MGD MGI:1859179
Others IRF3 NCBI