AKIP1 - A-kinase interacting protein 1 Gene

Homo sapiens

Also known as BCA3; C11orf17

Gene ID: 56672 | Gene type: protein coding

About AKIP1

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:8,911,189-8,920,079 (from NCBI)

This gene has 11 transcripts (splice variants) and 170 orthologues. Ubiquitous expression in thyroid (RPKM 4.3), adrenal (RPKM 4.1) and 25 other tissues.

Summary

This gene encodes a nuclear protein that interacts with protein kinase A catalytic subunit, and regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]

AKIP1 Products(4)

mRNA	Protein	Name
NM_001206646.2	NP_001193575.1	A-kinase-interacting protein 1 isoform b
NM_001206647.2	NP_001193576.1	A-kinase-interacting protein 1 isoform c
NM_001206648.2	NP_001193577.1	A-kinase-interacting protein 1 isoform d
NM_020642.4	NP_065693.2	A-kinase-interacting protein 1 isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15630084	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

A-kinase-interacting protein 1

A kinase (PRKA) interacting protein 1

AKIP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	AKIP1	Q9NQ31	q9y649_human	Homo sapiens	Q9Y649	Validated Y2H	32814053
Intra	AKIP1	Q9NQ31	q9y649_human	Homo sapiens	Q9Y649	Y2H Array	32814053
Intra	AKIP1	Q9NQ31	q9y649_human	Homo sapiens	Q9Y649	Y2H Pooling	32814053
Intra	AKIP1	Q9NQ31	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	AKIP1	Q9NQ31	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	AKIP1	Q9NQ31	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	AKIP1	Q9NQ31	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	AKIP1	Q9NQ31	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	AKIP1	Q9NQ31	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	AKIP1	Q9NQ31	PRKACA	Homo sapiens	P17612	Y2H	15630084
Intra	AKIP1	Q9NQ31	PRKACA	Homo sapiens	P17612	Pull Down	15630084
Intra	AKIP1	Q9NQ31	PRKACA	Homo sapiens	P17612	CoIP	15630084

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00526	AKIP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	AKIP1	RGD	RGD:1306959
Macaca mulatta	AKIP1	VGNC	VGNC:69600
Canis familiaris	AKIP1	VGNC	VGNC:37764
Bos taurus	AKIP1	VGNC	VGNC:25792
Felis catus	AKIP1	VGNC	VGNC:59720
Mus musculus	AKIP1	MGD	MGI:3041226

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