DPYSL5 - dihydropyrimidinase like 5 Gene

Homo sapiens

Also known as CV2; CRAM; CRMP5; RTSC4; Ulip6; CRMP-5

Gene ID: 56896 | Gene type: protein coding

About DPYSL5

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:26,847,995-26,950,351 (from NCBI)

This gene has 7 transcripts (splice variants), 255 orthologues, 5 paralogues and is associated with 3 phenotypes. Biased expression in brain (RPKM 10.7), testis (RPKM 2.0) and 1 other tissue.

Summary

This gene encodes a member of the CRMP (collapsing response mediator protein) family thought to be involved in neural development. Antibodies to the encoded protein were found in some patients with neurologic symptoms who had paraneoplastic syndrome. A pseudogene of this gene is found on chromosome 11. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]

DPYSL5 Products(3)

mRNA	Protein	Name
NM_001253723.2	NP_001240652.1	dihydropyrimidinase-related protein 5
NM_001253724.2	NP_001240653.1	dihydropyrimidinase-related protein 5
NM_020134.4	NP_064519.2	dihydropyrimidinase-related protein 5

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	33894126	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DPYSL5 Protein Structure

Amidohydro_1

0
100
200
300
400
500
564 a.a.

Protein Preferred Names

Protein Names

dihydropyrimidinase-related protein 5

CRMP3-associated molecule

DPYSL5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DPYSL5	Q9BPU6	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	DPYSL5	Q9BPU6	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	DPYSL5	Q9BPU6	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	DPYSL5	Q9BPU6	DPYSL2	Homo sapiens	Q16555	Anti Tag CoIP	33961781
Intra	DPYSL5	Q9BPU6	DPYSL2	Homo sapiens	Q16555	Anti Tag CoIP	28514442
Intra	DPYSL5	Q9BPU6	DPYSL2	Homo sapiens	Q16555	Y2H Array	25416956
Intra	DPYSL5	Q9BPU6	DPYSL2	Homo sapiens	Q16555	Y2H Array	32296183
Intra	DPYSL5	Q9BPU6	DPYSL2	Homo sapiens	Q16555	Y2H Array	29892012
Intra	DPYSL5	Q9BPU6	DPYSL2	Homo sapiens	Q16555	Y2H Prey Pooling	32296183
Intra	DPYSL5	Q9BPU6	DPYSL2	Homo sapiens	Q16555	Y2H Array	31515488
Intra	DPYSL5	Q9BPU6	CFAP161	Homo sapiens	Q6P656	Y2H Array	32296183
Intra	DPYSL5	Q9BPU6	CFAP161	Homo sapiens	Q6P656	Y2H Prey Pooling	32296183
Intra	DPYSL5	Q9BPU6	q9y649_human	Homo sapiens	Q9Y649	Validated Y2H	32814053
Intra	DPYSL5	Q9BPU6	q9y649_human	Homo sapiens	Q9Y649	Y2H Array	32814053
Intra	DPYSL5	Q9BPU6	q9y649_human	Homo sapiens	Q9Y649	Y2H Pooling	32814053
Intra	DPYSL5	Q9BPU6	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	DPYSL5	Q9BPU6	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	DPYSL5	Q9BPU6	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	DPYSL5	Q9BPU6	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	DPYSL5	Q9BPU6	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	DPYSL5	Q9BPU6	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	DPYSL5	Q9BPU6	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	DPYSL5	Q9BPU6	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	DPYSL5	Q9BPU6	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	DPYSL5	Q9BPU6	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	DPYSL5	Q9BPU6	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	DPYSL5	Q9BPU6	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	DPYSL5	Q9BPU6	HIP1	Homo sapiens	O00291	Validated Y2H	32814053
Intra	DPYSL5	Q9BPU6	HIP1	Homo sapiens	O00291	Y2H Array	32814053
Intra	DPYSL5	Q9BPU6	HIP1	Homo sapiens	O00291	Y2H Pooling	32814053
Intra	DPYSL5	Q9BPU6	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	DPYSL5	Q9BPU6	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	DPYSL5	Q9BPU6	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	DPYSL5	Q9BPU6	COQ8A	Homo sapiens	Q8NI60	Y2H Array	32814053
Intra	DPYSL5	Q9BPU6	COQ8A	Homo sapiens	Q8NI60	Validated Y2H	32814053
Intra	DPYSL5	Q9BPU6	COQ8A	Homo sapiens	Q8NI60	Y2H Pooling	32814053
Intra	DPYSL5	Q9BPU6	PEX1	Homo sapiens	O43933	Y2H Array	32814053
Intra	DPYSL5	Q9BPU6	PEX1	Homo sapiens	O43933	Validated Y2H	32814053
Intra	DPYSL5	Q9BPU6	PEX1	Homo sapiens	O43933	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Ritscher-Schinzel Syndrome 4

RTSC4

Non-Specific Syndromic Intellectual Disability

Complex Neurodevelopmental Disorder

Thymoma

Primary Thymic Epithelial Neoplasm	Primary Thymic Epithelial Tumor
Thymus Neoplasms

Ritscher-Schinzel Syndrome

3c Syndrome	Ccc Dysplasia
Craniocerebellocardiac Dysplasia	Cranio-Cerebello-Cardiac Dysplasia

Optic Neuritis

Inflammatory Optic Neuropathy

Chorea Gravidarum

Anal Spasm

Proctospasm	Anorectal Spasm
Rectal Spasm

Vascular Myelopathy

Vascular Myelopathies

Choroid Plexus Meningioma

Choroid Meningioma

Meningioma Of The Choroid Plexus

Neuroretinitis

Juxtapapillary Focal Retinitis And Retinochoroiditis	Retinitis
Focal Retinitis And Retinochoroiditis, Juxtapapillary	Papilloretinitis

Autoimmune Optic Neuritis

Autoimmune Epilepsy

Transverse Myelitis

Myelitis Transverse

Myelitis, Transverse

Nutritional Optic Neuropathy

Cerebellopontine Angle Meningioma

Meningioma Of The Cerebellar Pontine Angle

Polyradiculopathy

La Crosse Encephalitis

California Encephalitis	California Virus Encephalitis
Neuroinvasive California Encephalitis Virus Infection	Californian Encephalitis
Encephalitis, California	California Meningoencephalitis
California Encephalitis Virus Infection	California Encephalitis Virus Infection Neuroinvasive Disease
California Meningoencephalitis Virus Disease	California Serogroup Virus Neuroinvasive Disease
California Viral Encephalitis	Ce - [California Encephalitis]
Lac - [La Crosse Encephalitis]

Autoimmune Disease Of Peripheral Nervous System

Thymus Gland Disease

Disease Of Thymus Gland

Neuritis

Peripheral Neuritis

Limbic Encephalitis

Thymus Cancer

Thymic Neoplasm	Thymic Tumor
Thymus Neoplasm	Thymus Neoplasms
Malignant Neoplasm Of Thymus	Neoplasm Of Thymus
Thymic Neoplasms	Thymoma, Familial
Thymic Carcinoma	Thymoma, Type C
Cancer Of Thymus	Malignant Tumour Of Thymus
Primary Malignant Neoplasm Of Thymus	Thymic Glandular Cancer
Thymus Gland Cancer

Choreatic Disease

Chorea

Hereditary Chorea

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Neurosarcoidosis

Cerebral Sarcoidosis

Plexopathy

Stiff-Person Syndrome

SPS	Stiff-Man Syndrome
Stiff Man Syndrome	Stiff Person Syndrome
Moersch-Woltman Syndrome	Sms
Stiff-Trunk Syndrome	Morsch Woltman Syndrome
Stiff Person Syndrome And Related Disorders	Stiff Person Spectrum Disorder
Classic Stiff Person Syndrome	Classic Sps
Focal Stiff Limb Syndrome	Focal Stiff-Person Syndrome
Stiff Leg Syndrome	Progressive Encephalomyelitis With Rigidity

Acute Disseminated Encephalomyelitis

Acute Disseminated Encephalitis	Adem
Ade	Encephalomyelitis Acute Disseminated
Encephalomyelitis, Acute Disseminated	Adem - [Acute Disseminated Encephalomyelitis]

Optic Papillitis

Papillitis

Papilledema

Anterograde Amnesia

Amnesia, Anterograde

Ritscher-Schinzel Syndrome 2

RTSC2

Brain Meningioma

Intracranial Meningioma

Mononeuritis Multiplex

Lingual-Facial-Buccal Dyskinesia

Orofacial Dyskinesia	Oro-Facial Dyskinesia
Dyskinesias

Neuromuscular Junction Disease

Neuromuscular Junction Diseases

Mononeuritis Of Upper Limb And Mononeuritis Multiplex

Myelitis

Spinal Cord Inflammation Nos	Radiculomyelitis Nos
Myeloradiculitis

Autoimmune Neuropathy

Whipple Disease

Intestinal Lipodystrophy	Whipple'S Disease
Intestinal Lipophagic Granulomatosis	Secondary Non-Tropical Sprue
Tropheryma Whippelii Infection	Whipples Disease

Cranial Nerve Disease

Cranial Nerve Disorder	Disorder Of Cranial Nerve
Cranial Nerve Diseases

Optic Nerve Disease

Optic Neuropathy	Disorder Of The Second Nerve
Optic Nerve Disorder	Optic Nerve
Abnormality Of The Optic Nerve	Optic Nerve Disorders
Neuropathy, Optic	Disorder Of The Optic Nerve

Mutism

Hyperekplexia

Hereditary Hyperekplexia	Kok Disease
Congenital Stiff Man Syndrome	Familial Startle Disease
Sthe	Stiff-Baby Syndrome
Hereditary Hyperexplexia	Startle Disease
Exaggerated Startle Reaction	Hyperexplexia Hereditary
Startle Disease, Familial	Startle Reaction, Exaggerated
Stiff-Man Syndrome, Congenital	Stiff-Person Syndrome, Congenital
Congenital Stiff-Man Syndrome	Congenital Stiff-Person Syndrome
Familial Hyperekplexia	Startle Syndrome
Stiff Baby Syndrome	Hyperekplexia, Hereditary
Stiff-Person Syndrome

Spinal Cord Disease

Spinal Cord Diseases	Myelopathy
Bone Marrow Diseases

Cerebellar Disease

Cerebellar Diseases	Cerebellar Dysfunction
Cerebellar Abnormality	Cerebellar Disorders

Movement Disease

Movement Disorders

Movement Disorder

Peripheral Nervous System Disease

Peripheral Neuropathy	Peripheral Nerve Disease
Peripheral Nerve Disorders	Neuropathy, Peripheral
Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03984	DPYSL5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DPYSL5	MGD	MGI:1929772
Rattus norvegicus	DPYSL5	RGD	RGD:620467
Canis familiaris	DPYSL5	VGNC	VGNC:40085
Bos taurus	DPYSL5	VGNC	VGNC:28198
Macaca mulatta	DPYSL5	VGNC	VGNC:71872
Felis catus	DPYSL5	VGNC	VGNC:61618