WRNIP1 - WRN helicase interacting protein 1 Gene

Homo sapiens

Also known as WHIP; FAP93; CFAP93; bA420G6.2

Gene ID: 56897 | Gene type: protein coding

About WRNIP1

Cytogenetic location: 6p25.2 Genomic coordinates (GRCh38): 6:2,765,393-2,786,952 (from NCBI)

This gene has 5 transcripts (splice variants) and 192 orthologues. Ubiquitous expression in thyroid (RPKM 15.6), placenta (RPKM 14.5) and 25 other tissues.

Summary

Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA Polymerase delta and increases the initiation frequency of DNA Polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene. [provided by RefSeq, Jul 2012]

WRNIP1 Products(2)

mRNA	Protein	Name
NM_020135.3	NP_064520.2	ATPase WRNIP1 isoform 1
NM_130395.3	NP_569079.1	ATPase WRNIP1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP hydrolysis activity	IMP IMP: Inferred from mutant phenotype	15670210	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	15670210	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15670210	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA synthesis involved in DNA repair	IDA IDA: Inferred from direct assay	15670210	GOA
involved in regulation of DNA-templated DNA replication initiation	IDA IDA: Inferred from direct assay	15670210	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
colocalizes with chromosome, telomeric region	IDA IDA: Inferred from direct assay	24270157	GOA
located in nucleus	IDA IDA: Inferred from direct assay	17888034	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	17888034	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WRNIP1 Protein Structure

AAA

MgsA_C

0
200
400
600
665 a.a.

Protein Preferred Names

Protein Names

ATPase WRNIP1

Werner helicase interacting protein 1

WRNIP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	WRNIP1	Q96S55	WRNIP1	Homo sapiens	Q96S55	GMS	15670210
Intra	WRNIP1	Q96S55	POLD1	Homo sapiens	P28340	Anti Tag CoIP	15670210
Intra	WRNIP1	Q96S55	TOLLIP	Homo sapiens	Q9H0E2	Anti Tag CoIP	21903422
Intra	WRNIP1	Q96S55	FXR1	Homo sapiens	P51114	Y2H Pooling	21653829
Intra	WRNIP1	Q96S55	POLD4	Homo sapiens	Q9HCU8	Anti Tag CoIP	15670210
Intra	WRNIP1	Q96S55	POLD2	Homo sapiens	P49005	Anti Tag CoIP	15670210
Intra	WRNIP1	Q96S55	q7ard3_yerpe	Yersinia pestis	Q7ARD3	Y2H Pooling	20711500
Intra	WRNIP1	Q96S55	WRNIP1	Homo sapiens	Q96S55	Density Sedimentation	15670210

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Werner Syndrome

Werner'S Syndrome	WRN
Adult Progeria	Ws
Adult Premature Ageing Syndrome	Adult Premature Aging Syndrome
Werners Syndrome

Spinal Canal Intradural Extramedullary Neoplasm

Intradural Extramedullary Spinal Tumors

Intradural Extramedullary Spinal Canal Neoplasm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15848	WRNIP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	WRNIP1	RGD	RGD:628836
Macaca mulatta	WRNIP1	VGNC	VGNC:79293
Felis catus	WRNIP1	VGNC	VGNC:102548
Bos taurus	WRNIP1	VGNC	VGNC:54245
Canis familiaris	WRNIP1	VGNC	VGNC:48434
Mus musculus	WRNIP1	MGD	MGI:1926153

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