2. Gene
  3. PSMB5 - proteasome 20S subunit beta 5 Gene

PSMB5 - proteasome 20S subunit beta 5 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MB1; LMPX

Gene ID: 5693 | Gene type: protein coding

About PSMB5

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:23,025,851-23,035,220 (from NCBI)

This gene has 6 transcripts (splice variants), 217 orthologues and 18 paralogues. Ubiquitous expression in brain (RPKM 31.9), placenta (RPKM 30.5) and 25 other tissues.

Summary

The Proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave Peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified Proteasome, the immunoproteasome, is the processing of class I MHC Peptides. This gene encodes a member of the Proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit in the Proteasome. This catalytic subunit is not present in the immunoproteasome and is replaced by catalytic subunit 3i (Proteasome beta 8 subunit). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]

PSMB5 Products(3)

mRNA Protein Name
NM_001130725.1 NP_001124197.1 proteasome subunit beta type-5 isoform 2
NM_001144932.3 NP_001138404.1 proteasome subunit beta type-5 isoform 3
NM_002797.5 NP_002788.1 proteasome subunit beta type-5 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables peptidase activity IDA
IDA: Inferred from direct assay
17540904 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
14733938 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within proteolysis IDA
IDA: Inferred from direct assay
17540904 GOA
Cellular Component GO Annotation Evidence Reference Source
is active in cytoplasm IDA
IDA: Inferred from direct assay
34711951 GOA
is active in nucleus IDA
IDA: Inferred from direct assay
34711951 GOA
part of proteasome complex IDA
IDA: Inferred from direct assay
17323924 GOA
part of proteasome core complex IDA
IDA: Inferred from direct assay
34711951 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSMB5 Protein Structure

Proteasome

Proteasome: Proteasome subunit (56 - 238)

  • 0
  • 100
  • 200
  • 263 a.a.
Protein Preferred Names Protein Names

proteasome subunit beta type-5

PSX large multifunctional protease X

PSMB5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PSMB5 P28074 DUSP29 Homo sapiens Q68J44
Y2H Prey Pooling
32296183
Intra
PSMB5 P28074 DUSP29 Homo sapiens Q68J44
Validated Y2H
32296183
Intra
PSMB5 P28074 DUSP29 Homo sapiens Q68J44
Y2H Array
32296183
Intra
PSMB5 P28074 CCDC150 Homo sapiens Q8NCX0-3
Y2H Prey Pooling
32296183
Intra
PSMB5 P28074 CCDC150 Homo sapiens Q8NCX0-3
Validated Y2H
32296183
Intra
PSMB5 P28074 CCDC150 Homo sapiens Q8NCX0-3
Y2H Array
32296183
Intra
PSMB5 P28074 CLP1 Homo sapiens Q92989
Validated Y2H
32296183
Intra
PSMB5 P28074 BAG4 Homo sapiens O95429
Y2H Prey Pooling
32296183
Intra
PSMB5 P28074 BAG4 Homo sapiens O95429
Y2H Array
32296183
Intra
PSMB5 P28074 LSM1 Homo sapiens O15116
Y2H Array
32296183
Intra
PSMB5 P28074 LSM1 Homo sapiens O15116
Y2H Prey Pooling
32296183
Intra
PSMB5 P28074 PSMB1 Homo sapiens P20618
Anti Tag CoIP
35271311
Intra
PSMB5 P28074 PSMB7 Homo sapiens Q99436
Y2H
17948026
Intra
PSMB5 P28074 PSMB3 Homo sapiens P49720
Y2H
14733938
Intra
PSMB5 P28074 POMP Homo sapiens Q9Y244
Y2H
14733938
Intra
PSMB5 P28074 POMP Homo sapiens Q9Y244
Y2H
17948026
Intra
PSMB5 P28074 POMP Homo sapiens Q9Y244
Anti Tag CoIP
35271311
Intra
PSMB5 P28074 TCHP Homo sapiens Q9BT92
Validated Y2H
32296183
Intra
PSMB5 P28074 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
Intra
PSMB5 P28074 IKBKG Homo sapiens Q9Y6K9
Y2H Prey Pooling
32296183
Intra
PSMB5 P28074 IKBKG Homo sapiens Q9Y6K9
Validated Y2H
32296183
Intra
PSMB5 P28074 IKBKG Homo sapiens Q9Y6K9
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

PSMB5 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83719 PSMB5/MB1 Antibody WB, IHC-P, ICC/IF, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11305 PSMB5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PSMB5 VGNC VGNC:76445
Canis familiaris PSMB5 VGNC VGNC:45097
Bos taurus PSMB5 VGNC VGNC:33449
Felis catus PSMB5 VGNC VGNC:80876
Rattus norvegicus PSMB5 RGD RGD:61879
Mus musculus PSMB5 MGD MGI:1194513