PSMB7 - proteasome 20S subunit beta 7 Gene

Homo sapiens

Gene ID: 5695 | Gene type: protein coding

About PSMB7

Cytogenetic location: 9q33.3 Genomic coordinates (GRCh38): 9:124,353,465-124,415,442 (from NCBI)

This gene has 6 transcripts (splice variants), 217 orthologues and 18 paralogues. Ubiquitous expression in testis (RPKM 70.4), adrenal (RPKM 65.0) and 25 other tissues.

Summary

The Proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave Peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the Proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the Proteasome. Expression of this catalytic subunit is downregulated by gamma interferon, and proteolytic processing is required to generate a mature subunit. A pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Jul 2012]

PSMB7 Products(1)

mRNA	Protein	Name
NM_002799.4	NP_002790.1	proteasome subunit beta type-7 precursor

PSMB7 Protein Structure

Proteasome

Pr_beta_C

0
100
200
277 a.a.

Protein Preferred Names

Protein Names

proteasome subunit beta type-7

epididymis secretory sperm binding protein

PSMB7 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PSMB7	Q99436	PSMB5	Homo sapiens	P28074	Y2H	14733938
Intra	PSMB7	Q99436	PSMB5	Homo sapiens	P28074	Anti Tag CoIP	28514442
Intra	PSMB7	Q99436	PSMB5	Homo sapiens	P28074	Anti Bait CoIP	20723761
Intra	PSMB7	Q99436	PSMB5	Homo sapiens	P28074	Anti Tag CoIP	33961781
Intra	PSMB7	Q99436	PSMB6	Homo sapiens	P28072	Anti Tag CoIP	33961781
Intra	PSMB7	Q99436	PSMB6	Homo sapiens	P28072	Y2H	17948026
Intra	PSMB7	Q99436	PSMB6	Homo sapiens	P28072	Anti Tag CoIP	28514442
Intra	PSMB7	Q99436	PSMB6	Homo sapiens	P28072	Y2H	14733938
Intra	PSMB7	Q99436	PSMD4	Homo sapiens	P55036	Anti Tag CoIP	35271311
Intra	PSMB7	Q99436	PSMB1	Homo sapiens	P20618	Y2H	17948026
Intra	PSMB7	Q99436	PSMB1	Homo sapiens	P20618	Anti Tag CoIP	35271311
Intra	PSMB7	Q99436	PSMB1	Homo sapiens	P20618	Anti Bait CoIP	20723761
Intra	PSMB7	Q99436	PSMB1	Homo sapiens	P20618	Anti Tag CoIP	33961781
Intra	PSMB7	Q99436	PSMB9	Homo sapiens	P28065	Anti Tag CoIP	33961781
Intra	PSMB7	Q99436	PSMB9	Homo sapiens	P28065	Anti Tag CoIP	28514442
Intra	PSMB7	Q99436	PSMB9	Homo sapiens	P28065	Anti Bait CoIP	20723761
Intra	PSMB7	Q99436	PSMB3	Homo sapiens	P49720	Y2H	14733938
Intra	PSMB7	Q99436	PSMB4	Homo sapiens	P28070	Anti Tag CoIP	33961781
Intra	PSMB7	Q99436	POMP	Homo sapiens	Q9Y244	Anti Tag CoIP	35271311
Intra	PSMB7	Q99436	POMP	Homo sapiens	Q9Y244	Anti Tag CoIP	33961781
Intra	PSMB7	Q99436	POMP	Homo sapiens	Q9Y244	Y2H	17948026
Intra	PSMB7	Q99436	POMP	Homo sapiens	Q9Y244	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11307	PSMB7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PSMB7	VGNC	VGNC:69111
Mus musculus	PSMB7	MGD	MGI:107637
Bos taurus	PSMB7	VGNC	VGNC:33451
Rattus norvegicus	PSMB7	RGD	RGD:621093
Canis familiaris	PSMB7	VGNC	VGNC:55791

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