2. Gene
  3. CTNNBIP1 - catenin beta interacting protein 1 Gene

CTNNBIP1 - catenin beta interacting protein 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ICAT

Gene ID: 56998 | Gene type: protein coding

About CTNNBIP1

Cytogenetic location: 1p36.22 Genomic coordinates (GRCh38): 1:9,848,276-9,910,269 (from NCBI)

This gene has 4 transcripts (splice variants), 181 orthologues and 1 paralogue. Ubiquitous expression in skin (RPKM 77.0), esophagus (RPKM 25.4) and 24 other tissues.

Summary

The protein encoded by this gene binds CTNNB1 and prevents interaction between CTNNB1 and TCF family members. The encoded protein is a negative regulator of the Wnt signaling pathway. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

CTNNBIP1 Products(2)

mRNA Protein Name
NM_001012329.2 NP_001012329.1 beta-catenin-interacting protein 1
NM_020248.3 NP_064633.1 beta-catenin-interacting protein 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables armadillo repeat domain binding IPI
IPI: Inferred from physical interaction
12408825 GOA
enables beta-catenin binding IPI
IPI: Inferred from physical interaction
12408825 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12408824 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
18977368 GOA
involved in negative regulation of mesenchymal cell proliferation IMP
IMP: Inferred from mutant phenotype
18977368 GOA
involved in negative regulation of protein binding IDA
IDA: Inferred from direct assay
12408825 GOA
involved in positive regulation of monocyte differentiation IMP
IMP: Inferred from mutant phenotype
19569129 GOA
involved in positive regulation of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
18977368 GOA
involved in regulation of vascular permeability involved in acute inflammatory response IMP
IMP: Inferred from mutant phenotype
18287330 GOA
Cellular Component GO Annotation Evidence Reference Source
part of beta-catenin destruction complex IDA
IDA: Inferred from direct assay
16188939 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
19569129 GOA
located in cytosol IDA
IDA: Inferred from direct assay
18287330 GOA
located in nucleus IDA
IDA: Inferred from direct assay
18287330 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CTNNBIP1 Protein Structure

ICAT

ICAT: Beta-catenin-interacting protein ICAT (1 - 81)

  • 0
  • 81 a.a.
Protein Preferred Names Protein Names

beta-catenin-interacting protein 1

beta-catenin-interacting protein ICAT

CTNNBIP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra CTNNBIP1 Q9NSA3 KRTAP10-7 Homo sapiens P60409
Y2H Array
25416956
Intra CTNNBIP1 Q9NSA3 MSS51 Homo sapiens Q4VC12
Y2H Array
32296183
Intra CTNNBIP1 Q9NSA3 MSS51 Homo sapiens Q4VC12
Y2H Prey Pooling
32296183
Intra CTNNBIP1 Q9NSA3 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
Intra CTNNBIP1 Q9NSA3 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
Intra CTNNBIP1 Q9NSA3 SPATA24 Homo sapiens Q86W54-2
Y2H Prey Pooling
32296183
Intra CTNNBIP1 Q9NSA3 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra CTNNBIP1 Q9NSA3 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra CTNNBIP1 Q9NSA3 REL Homo sapiens Q04864
Validated Y2H
25416956
Intra CTNNBIP1 Q9NSA3 REL Homo sapiens Q04864
Y2H Array
25416956
Intra CTNNBIP1 Q9NSA3 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
32296183
Intra CTNNBIP1 Q9NSA3 KRTAP5-9 Homo sapiens P26371
Y2H Array
32296183
Cross CTNNBIP1 Q9NSA3 Ctnnb1 Mus musculus Q02248
ITC
16293619
Intra CTNNBIP1 Q9NSA3 CTNNB1 Homo sapiens P35222
Anti Tag CoIP
28514442
Intra CTNNBIP1 Q9NSA3 CTNNB1 Homo sapiens P35222
X-Ray Diffraction
12408824
Intra CTNNBIP1 Q9NSA3 CTNNB1 Homo sapiens P35222
Competition Binding
18287330
Intra CTNNBIP1 Q9NSA3 CTNNB1 Homo sapiens P35222
Anti Tag CoIP
33961781
Intra CTNNBIP1 Q9NSA3 CTNNB1 Homo sapiens P35222
Anti Tag CoIP
21885566
Intra CTNNBIP1 Q9NSA3 CTNNB1 Homo sapiens P35222
Anti Bait CoIP
17353931
Intra CTNNBIP1 Q9NSA3 CTNNB1 Homo sapiens P35222
Pull Down
21885566
Intra CTNNBIP1 Q9NSA3 CTNNB1 Homo sapiens P35222
Anti Bait CoIP
21885566
Intra CTNNBIP1 Q9NSA3 CTNNB1 Homo sapiens P35222
Pull Down
18287330
Intra CTNNBIP1 Q9NSA3 INCA1 Homo sapiens Q0VD86
Validated Y2H
25416956
Intra CTNNBIP1 Q9NSA3 JUP Homo sapiens P14923
Y2H Prey Pooling
32296183
Intra CTNNBIP1 Q9NSA3 JUP Homo sapiens P14923
Anti Tag CoIP
33961781
Intra CTNNBIP1 Q9NSA3 JUP Homo sapiens P14923
Y2H Array
32296183
Intra CTNNBIP1 Q9NSA3 JUP Homo sapiens P14923
Anti Bait CoIP
17353931
Intra CTNNBIP1 Q9NSA3 USHBP1 Homo sapiens Q8N6Y0
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cheilitis
Anterior Segment Dysgenesis 5

Anterior Segment Dysgenesis 5, Multiple Subtypes

ASGD5

Dysgenesis, Anterior Segment, Type 5, Multiple Subtypes
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Osteogenesis Imperfecta, Type I

Osteogenesis Imperfecta Type I

OI1

Oi, Type I

Osteogenesis Imperfecta Tarda

Osteogenesis Imperfecta With Blue Sclerae

Osteogenesis Imperfecta Type 1

Adair-Dighton Syndrome

Mild Osteogenesis Imperfecta

Non-Deforming Osteogenesis Imperfecta

Oi Type 1

Van Der Hoeve Syndrome

Classic Non-Deforming Oi With Blue Sclerae

Osteogenesis Imperfecta 1

Oi-I

Osteopenic Non-Fracture Syndrome

Osteogenesis Imperfecta, Mild

Osteogenesis Imperfecta

Lobstein'S Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03309 CTNNBIP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CTNNBIP1 VGNC VGNC:80177
Rattus norvegicus CTNNBIP1 RGD RGD:1562749
Bos taurus CTNNBIP1 VGNC VGNC:27803
Mus musculus CTNNBIP1 MGD MGI:1915756