BAG1 - BAG cochaperone 1 Gene

Homo sapiens

Also known as HAP; BAG-1; RAP46

Gene ID: 573 | Gene type: protein coding

About BAG1

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:33,252,471-33,264,708 (from NCBI)

This gene has 11 transcripts (splice variants) and 199 orthologues. Ubiquitous expression in kidney (RPKM 19.7), colon (RPKM 18.5) and 25 other tissues.

Summary

The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to Apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. Multiple protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) initiation codon, and three alternative downstream AUG initiation codons. A related pseudogene has been defined on chromosome X. [provided by RefSeq, Feb 2010]

BAG1 Products(4)

mRNA	Protein	Name
NM_001172415.2	NP_001165886.1	BAG family molecular chaperone regulator 1 isoform BAG-1S
NM_001349286.2	NP_001336215.1	BAG family molecular chaperone regulator 1 isoform BAG-1M
NM_001349299.2	NP_001336228.1	BAG family molecular chaperone regulator 1 isoform BAG1
NM_004323.6	NP_004314.6	BAG family molecular chaperone regulator 1 isoform BAG-1L

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables adenyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	24318877	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9305631	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	16207813	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in chaperone cofactor-dependent protein refolding	IDA IDA: Inferred from direct assay	12853476	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	9679980	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BAG1 Protein Structure

ubiquitin

BAG

0
100
200
300
345 a.a.

Protein Preferred Names

Protein Names

BAG family molecular chaperone regulator 1

BCL2 associated athanogene 1

BAG1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	BAG1	Q99933	HSPA8	Homo sapiens	Q96IS6	Validated Y2H	25416956
Intra	BAG1	Q99933	HSPA8	Homo sapiens	Q96IS6	Y2H Array	25416956
Intra	BAG1	Q99933	MLF2	Homo sapiens	Q15773	Anti Tag CoIP	25036637
Intra	BAG1	Q99933	MLF2	Homo sapiens	Q15773	Lumier	25036637
Intra	BAG1	Q99933	HSPA8	Homo sapiens	P11142	Validated Y2H	26871637
Intra	BAG1	Q99933	HSPA8	Homo sapiens	P11142	Y2H Prey Pooling	26871637
Intra	BAG1	Q99933	HSPA8	Homo sapiens	P11142	SPR	19800331
Intra	BAG1	Q99933	HSPA8	Homo sapiens	P11142	Y2H Array	26871637
Intra	BAG1	Q99933	STUB1	Homo sapiens	Q9UNE7	Anti Tag CoIP	25036637
Intra	BAG1	Q99933	PSMD2	Homo sapiens	Q13200	Lumier	25036637
Intra	BAG1	Q99933	PSMD2	Homo sapiens	Q13200	Anti Tag CoIP	33961781
Intra	BAG1	Q99933	PSMD2	Homo sapiens	Q13200	Y2H Array	25416956
Intra	BAG1	Q99933	PSMD2	Homo sapiens	Q13200	Y2H Array	32296183
Intra	BAG1	Q99933	PSMD2	Homo sapiens	Q13200	Y2H Prey Pooling	25416956
Intra	BAG1	Q99933	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	25416956
Intra	BAG1	Q99933	TRIM27	Homo sapiens	P14373	Y2H Array	31515488
Intra	BAG1	Q99933	TRIM27	Homo sapiens	P14373	Validated Y2H	26871637
Intra	BAG1	Q99933	TRIM27	Homo sapiens	P14373	Y2H Array	25416956
Intra	BAG1	Q99933	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	26871637
Intra	BAG1	Q99933	TRIM27	Homo sapiens	P14373	Y2H Array	26871637
Intra	BAG1	Q99933	q96be0_human	Homo sapiens	Q96BE0	Lumier	25036637
Intra	BAG1	Q99933	q53fc7_human	Homo sapiens	Q53FC7	Lumier	25036637

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Coccidiosis

Intestinal Coccidiosis

Enteric Coccidiosis

Laryngeal Squamous Cell Carcinoma

Epidermoid Carcinoma Of The Larynx	Squamous Cell Carcinoma Of Larynx
Squamous Cell Carcinoma Of The Larynx	Squamous Cell Carcinoma Of Head And Neck

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia	B-Cell Chronic Lymphocytic Leukemia
CLL	B-Cell Chronic Lymphoid Leukemia
Chronic Lymphatic Leukemia	Chronic Lymphocytic Leukaemia
Lymphoplasmacytic Leukemia	Small Lymphocytic Lymphoma
Leukemia, Chronic Lymphatic	B-Cell Chronic Lymphocytic Leukaemia
Chronic Lymphatic Leukaemia	Lymphoplasmacytic Leukaemia
B Cell Chronic Lymphocytic Leukemia	Chronic B-Cell Lymphocytic Leukemia
Leukemia, Lymphocytic, Chronic	B-Cll
Chronic Lymphoid Leukemia	Leukemia Lymphocytic Chronic
Lymphoma Small Lymphocytic	Leukemia, Lymphocytic, Chronic, B-Cell

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-124611	JG-231		98.81%	Unkown
HY-124811	IRES-C11	Inhibitor	99.03%	Unkown
HY-RS01342	BAG1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	BAG1	VGNC	VGNC:84875
Felis catus	BAG1	VGNC	VGNC:69043
Bos taurus	BAG1	VGNC	VGNC:26405
Canis familiaris	BAG1	VGNC	VGNC:38363
Mus musculus	BAG1	MGD	MGI:108047
Rattus norvegicus	BAG1	RGD	RGD:1305203

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