ADGRB3 - adhesion G protein-coupled receptor B3 Gene

Homo sapiens

Also known as BAI3

Gene ID: 577 | Gene type: protein coding

About ADGRB3

Cytogenetic location: 6q12-q13 Genomic coordinates (GRCh38): 6:68,635,282-69,389,506 (from NCBI)

This gene has 6 transcripts (splice variants), 216 orthologues and 42 paralogues. Biased expression in brain (RPKM 7.6), adrenal (RPKM 0.8) and 3 other tissues.

Summary

This p53-target gene encodes a brain-specific angiogenesis inhibitor, a seven-span transmembrane protein, and is thought to be a member of the Secretin Receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities, and may also play a role in angiogenesis. [provided by RefSeq, Jul 2008]

ADGRB3 Products(1)

mRNA	Protein	Name
NM_001704.3	NP_001695.2	adhesion G protein-coupled receptor B3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21262840	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in myoblast fusion	IDA IDA: Inferred from direct assay	24567399	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IPI IPI: Inferred from physical interaction	21262840	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADGRB3 Protein Structure

TSP_1

HRM

GPS

7tm_2

0
300
600
900
1200
1522 a.a.

Protein Preferred Names

Protein Names

adhesion G protein-coupled receptor B3

brain-specific angiogenesis inhibitor 3

Recombinant ADGRB3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7675	BAI3 Protein, Human (HEK293, His)	O60242 (A25-T880)	≥95%

Related Diseases

Diseases

Alias

Polymicrogyria, Bilateral Frontoparietal

Bilateral Frontoparietal Polymicrogyria	BFPP
Cerebellar Ataxia With Neuronal Migration Defect

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Carey-Fineman-Ziter Syndrome 1

Carey-Fineman-Ziter Syndrome	CFZS
Congenital Nonprogressive Myopathy With Moebius And Robin Sequences	Myopathy, Congenital Nonprogressive, With Moebius Sequence And Robin Sequence
Cfz Syndrome	Carey Fineman Ziter Syndrome
Myopathy, Congenital Nonprogressive With Moebius And Robin Sequences	Myopathy-Moebius-Robin Syndrome
CFZS1	Moebius Sequence, Robin Complex, And Hypotonia
Congenital Non-Progressive Myopathy With Moebius And Robin Sequences

Usher Syndrome, Type Iic

Usher Syndrome Type 2c	USH2C
Usher Syndrome, Type 2c	Usher Syndrome, Type Iic, Gpr98/Pdzd7 Digenic
Usher Syndrome Type Iic	Usher Syndrome, Type 2c, Gpr98/Pdzd7 Digenic
Usher Syndrome 2c	Usher'S Syndrome Type 2c
Usher Syndrome Type Iic Gpr98/Pdzd7 Digenic

Vibratory Urticaria

Vibratory Angioedema	Dermodistortive Urticaria
VBU	Ddu
Angioedema, Vibratory

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00347	ADGRB3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ADGRB3	VGNC	VGNC:59318
Felis catus	ADGRB3	VGNC	VGNC:69077
Canis familiaris	ADGRB3	VGNC	VGNC:37635
Rattus norvegicus	ADGRB3	RGD	RGD:1309703
Macaca mulatta	ADGRB3	VGNC	VGNC:81006
Mus musculus	ADGRB3	MGD	MGI:2441837

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