PTPN4 - protein tyrosine phosphatase non-receptor type 4 Gene

Homo sapiens

Also known as MEG; PTPMEG; PTPMEG1

Gene ID: 5775 | Gene type: protein coding

About PTPN4

Cytogenetic location: 2q14.2 Genomic coordinates (GRCh38): 2:119,759,922-119,984,899 (from NCBI)

This gene has 12 transcripts (splice variants), 234 orthologues and 35 paralogues. Ubiquitous expression in thyroid (RPKM 7.2), brain (RPKM 5.8) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation. [provided by RefSeq, Jul 2008]

PTPN4 Products(1)

mRNA	Protein	Name
NM_002830.4	NP_002821.1	tyrosine-protein phosphatase non-receptor type 4

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16169070	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10940933	GOA
located in cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	10940933	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTPN4 Protein Structure

FERM_N

FERM_M

FERM_C

PDZ

Y_phosphatase

0
200
400
600
800
926 a.a.

Protein Preferred Names

Protein Names

tyrosine-protein phosphatase non-receptor type 4

PTPase-MEG1

PTPN4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PTPN4	P29074	LAMP2	Homo sapiens	P13473-2	Validated Y2H	32814053
Intra	PTPN4	P29074	LAMP2	Homo sapiens	P13473-2	Y2H Array	32814053
Intra	PTPN4	P29074	LAMP2	Homo sapiens	P13473-2	Y2H Pooling	32814053
Intra	PTPN4	P29074	KAT5	Homo sapiens	Q92993	Pull Down	16169070
Intra	PTPN4	P29074	KAT5	Homo sapiens	Q92993	Y2H Pooling	16169070
Intra	PTPN4	P29074	MAPK12	Homo sapiens	P53778	Enzymatic Study	25158884
Intra	PTPN4	P29074	CCK	Homo sapiens	P06307	Validated Y2H	32814053
Intra	PTPN4	P29074	CCK	Homo sapiens	P06307	Y2H Array	32814053
Intra	PTPN4	P29074	CCK	Homo sapiens	P06307	Y2H Pooling	32814053
Intra	PTPN4	P29074	CASP6	Homo sapiens	P55212	Y2H Array	32814053
Intra	PTPN4	P29074	CASP6	Homo sapiens	P55212	Y2H Pooling	32814053
Intra	PTPN4	P29074	CASP6	Homo sapiens	P55212	Validated Y2H	32814053
Intra	PTPN4	P29074	CRK	Homo sapiens	P46108	Anti Tag CoIP	21988832

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Rabies

Lyssa	Hydrophobia
St Hubert Disease

Mullegama-Klein-Martinez Syndrome

MKMS	Nedxcf
Neurodevelopmental Disorder, X-Linked, With Craniofacial Abnormalities	X-Linked Neurodevelopmental Disorder With Craniofacial Abnormalities

Toxic Diffuse Goiter

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11427	PTPN4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PTPN4	VGNC	VGNC:45177
Mus musculus	PTPN4	MGD	MGI:1099792
Rattus norvegicus	PTPN4	RGD	RGD:620712
Felis catus	PTPN4	VGNC	VGNC:69164
Bos taurus	PTPN4	VGNC	VGNC:33539
Macaca mulatta	PTPN4	VGNC	VGNC:76605

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