2. Gene
  3. PTPN7 - protein tyrosine phosphatase non-receptor type 7 Gene

PTPN7 - protein tyrosine phosphatase non-receptor type 7 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as LPTP; HEPTP; PTPNI; BPTP-4; LC-PTP

Gene ID: 5778 | Gene type: protein coding

About PTPN7

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:202,147,013-202,161,588 (from NCBI)

This gene has 20 transcripts (splice variants), 131 orthologues and 35 paralogues. Biased expression in bone marrow (RPKM 19.6), lymph node (RPKM 18.1) and 11 other tissues.

Summary

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The non-catalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2010]

PTPN7 Products(5)

mRNA Protein Name
NM_001199797.2 NP_001186726.1 tyrosine-protein phosphatase non-receptor type 7 isoform 3
NM_001364877.2 NP_001351806.1 tyrosine-protein phosphatase non-receptor type 7 isoform 4
NM_001364878.1 NP_001351807.1 tyrosine-protein phosphatase non-receptor type 7 isoform 1
NM_002832.4 NP_002823.4 tyrosine-protein phosphatase non-receptor type 7 isoform 1
NM_080588.3 NP_542155.1 tyrosine-protein phosphatase non-receptor type 7 isoform 2
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
10415025 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
10940933 GOA
located in cytoplasmic side of plasma membrane IDA
IDA: Inferred from direct assay
10940933 GOA
located in cytosol IDA
IDA: Inferred from direct assay
10940933 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTPN7 Protein Structure

Y_phosphatase

Y_phosphatase: Protein-tyrosine phosphatase (120 - 347)

  • 0
  • 100
  • 200
  • 300
  • 360 a.a.
Protein Preferred Names Protein Names

tyrosine-protein phosphatase non-receptor type 7

dual specificity phosphatase 1

Related Diseases

Diseases Alias
Toxic Diffuse Goiter
Erythrocytosis, Familial, 7

ECYT7

Erythrocytosis 7

Familial Erythrocytosis 7

Erythrocytosis, Alpha-Globin Type

Polycythemia, Alpha-Globin Type

Alpha-Globin Type Erythrocytosis

Alpha-Globin Type Polycythemia
Rasopathy

Ras/Mitogen-Activated Protein Kinase Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-141800 MurA-IN-1 Inhibitor 99.32% Unkown
HY-RS11430 PTPN7 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PTPN7 VGNC VGNC:33542
Macaca mulatta PTPN7 VGNC VGNC:76608
Mus musculus PTPN7 MGD MGI:2156893
Canis familiaris PTPN7 VGNC VGNC:45180
Rattus norvegicus PTPN7 RGD RGD:708516