PTPN7 - protein tyrosine phosphatase non-receptor type 7 Gene

Homo sapiens

Also known as LPTP; HEPTP; PTPNI; BPTP-4; LC-PTP

Gene ID: 5778 | Gene type: protein coding

About PTPN7

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:202,147,013-202,161,588 (from NCBI)

This gene has 20 transcripts (splice variants), 131 orthologues and 35 paralogues. Biased expression in bone marrow (RPKM 19.6), lymph node (RPKM 18.1) and 11 other tissues.

Summary

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The non-catalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2010]

PTPN7 Products(5)

mRNA	Protein	Name
NM_001199797.2	NP_001186726.1	tyrosine-protein phosphatase non-receptor type 7 isoform 3
NM_001364877.2	NP_001351806.1	tyrosine-protein phosphatase non-receptor type 7 isoform 4
NM_001364878.1	NP_001351807.1	tyrosine-protein phosphatase non-receptor type 7 isoform 1
NM_002832.4	NP_002823.4	tyrosine-protein phosphatase non-receptor type 7 isoform 1
NM_080588.3	NP_542155.1	tyrosine-protein phosphatase non-receptor type 7 isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10415025	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10940933	GOA
located in cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	10940933	GOA
located in cytosol	IDA IDA: Inferred from direct assay	10940933	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTPN7 Protein Structure

Y_phosphatase

0
100
200
300
360 a.a.

Protein Preferred Names

Protein Names

tyrosine-protein phosphatase non-receptor type 7

dual specificity phosphatase 1

PTPN7 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PTPN7	P35236	FLJ13057	Homo sapiens	Q53SE7	Y2H Prey Pooling	25416956
Intra	PTPN7	P35236	CCDC57	Homo sapiens	Q2TAC2	Y2H Prey Pooling	25416956
Cross	PTPN7	P35236	Mapk14	Mus musculus	P47811	Anti Tag CoIP	10415025
Intra	PTPN7	P35236	MAPK1	Homo sapiens	P28482	Anti Tag CoIP	10415025
Intra	PTPN7	P35236	MAPK1	Homo sapiens	P28482	Pull Down	10415025
Intra	PTPN7	P35236	MAPK1	Homo sapiens	P28482	PLA	25241761
Intra	PTPN7	P35236	MAPK1	Homo sapiens	P28482	Anti Tag CoIP	12592337

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Toxic Diffuse Goiter

Erythrocytosis, Familial, 7

ECYT7	Erythrocytosis 7
Familial Erythrocytosis 7	Erythrocytosis, Alpha-Globin Type
Polycythemia, Alpha-Globin Type	Alpha-Globin Type Erythrocytosis
Alpha-Globin Type Polycythemia

Rasopathy

Ras/Mitogen-Activated Protein Kinase Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-141800	MurA-IN-1	Inhibitor	99.32%	Unkown
HY-RS11430	PTPN7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PTPN7	VGNC	VGNC:33542
Macaca mulatta	PTPN7	VGNC	VGNC:76608
Mus musculus	PTPN7	MGD	MGI:2156893
Canis familiaris	PTPN7	VGNC	VGNC:45180
Rattus norvegicus	PTPN7	RGD	RGD:708516

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