PTPN12 - protein tyrosine phosphatase non-receptor type 12 Gene

Homo sapiens

Also known as PTPG1; PTP-PEST

Gene ID: 5782 | Gene type: protein coding

About PTPN12

Cytogenetic location: 7q11.23 Genomic coordinates (GRCh38): 7:77,537,295-77,640,069 (from NCBI)

This gene has 16 transcripts (splice variants), 139 orthologues, 35 paralogues and is associated with 1 phenotype. Ubiquitous expression in lung (RPKM 36.1), placenta (RPKM 29.5) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]

PTPN12 Products(3)

mRNA	Protein	Name
NM_001131008.2	NP_001124480.1	tyrosine-protein phosphatase non-receptor type 12 isoform 2
NM_001131009.2	NP_001124481.1	tyrosine-protein phosphatase non-receptor type 12 isoform 3
NM_002835.4	NP_002826.3	tyrosine-protein phosphatase non-receptor type 12 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables SH3 domain binding	IPI IPI: Inferred from physical interaction	9285683	GOA
enables phosphoprotein phosphatase activity	IDA IDA: Inferred from direct assay	27134172	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9285683	GOA
enables protein tyrosine phosphatase activity	EXP EXP: Inferred from Experiment	21376233	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to epidermal growth factor stimulus	IMP IMP: Inferred from mutant phenotype	27134172	GOA
involved in peptidyl-tyrosine dephosphorylation	IDA IDA: Inferred from direct assay	27134172	GOA
involved in protein dephosphorylation	IDA IDA: Inferred from direct assay	27134172	GOA
involved in regulation of epidermal growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	27134172	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTPN12 Protein Structure

Y_phosphatase

0
200
400
600
780 a.a.

Protein Preferred Names

Protein Names

tyrosine-protein phosphatase non-receptor type 12

protein-tyrosine phosphatase G1

Recombinant PTPN12 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76557	PTPN12 Protein, Human	Q05209 (N-G&P, M1-Q355)	≥95%
HY-P76558	PTPN12 Protein, Human (sf9, His-GST)	Q05209 (M1-Q355)	≥95%

Related Diseases

Diseases

Alias

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Pyogenic Sterile Arthritis, Pyoderma Gangrenosum, And Acne

Papa Syndrome	Fra
Familial Recurrent Arthritis	Pyogenic Arthritis, Pyoderma Gangrenosum And Acne
PAPAS	Pyogenic Arthritis-Pyoderma Gangrenosum-Acne Syndrome
Pyogenic Arthritis, Pyoderma Gangrenosum, And Severe Cystic Acne	Pyogenic Sterile Arthritis, Pyoderma Gangrenosum And Acne

Leiomyomatosis

Charcot-Marie-Tooth Disease

Cmt	Hmsn
Hereditary Motor And Sensory Neuropathy	Pma
Cmt - Charcot-Marie-Tooth Disease	Charcot Marie Tooth Disease
Charcot-Marie-Tooth Hereditary Neuropathy	Charcot-Marie-Tooth Syndrome
Peroneal Muscular Atrophy	Hereditary Motor And Sensory Neuropathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11417	PTPN12 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PTPN12	VGNC	VGNC:45169
Macaca mulatta	PTPN12	VGNC	VGNC:76598
Mus musculus	PTPN12	MGD	MGI:104673
Bos taurus	PTPN12	VGNC	VGNC:33531
Felis catus	PTPN12	VGNC	VGNC:69159
Rattus norvegicus	PTPN12	RGD	RGD:620894
Others	PTPN12	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.