CCNB1IP1 - cyclin B1 interacting protein 1 Gene

Homo sapiens

Also known as HEI10; C14orf18

Gene ID: 57820 | Gene type: protein coding

About CCNB1IP1

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:20,311,370-20,333,279 (from NCBI)

This gene has 16 transcripts (splice variants), 198 orthologues and is associated with 50 phenotypes. Ubiquitous expression in ovary (RPKM 41.4), thyroid (RPKM 28.8) and 24 other tissues.

Summary

HEI10 is a member of the E3 ubiquitin Ligase family and functions in progression of the cell cycle through G(2)/M.[supplied by OMIM, Apr 2004]

CCNB1IP1 Products(3)

mRNA	Protein	Name
NM_021178.5	NP_067001.3	E3 ubiquitin-protein ligase CCNB1IP1
NM_182849.3	NP_878269.1	E3 ubiquitin-protein ligase CCNB1IP1
NM_182852.4	NP_878272.1	E3 ubiquitin-protein ligase CCNB1IP1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12612082	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCNB1IP1 Protein Structure

zf-RING_5

0
100
200
277 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase CCNB1IP1

RING-type E3 ubiquitin transferase CCNB1IP1

CCNB1IP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CCNB1IP1	Q9NPC3	H1-3	Homo sapiens	P16402	Anti Tag CoIP	28514442
Intra	CCNB1IP1	Q9NPC3	H1-3	Homo sapiens	P16402	Anti Tag CoIP	33961781
Intra	CCNB1IP1	Q9NPC3	PRKAA2	Homo sapiens	P54646	Y2H Prey Pooling	25416956
Intra	CCNB1IP1	Q9NPC3	PRKAA2	Homo sapiens	P54646	Y2H Array	25416956
Intra	CCNB1IP1	Q9NPC3	EPM2AIP1	Homo sapiens	Q7L775	Validated Y2H	25416956
Intra	CCNB1IP1	Q9NPC3	EPM2AIP1	Homo sapiens	Q7L775	Y2H Array	25416956
Intra	CCNB1IP1	Q9NPC3	KRT15	Homo sapiens	P19012	Y2H Array	25416956
Intra	CCNB1IP1	Q9NPC3	CCNB1IP1	Homo sapiens	Q9NPC3	Y2H Array	31515488
Intra	CCNB1IP1	Q9NPC3	CCNB1IP1	Homo sapiens	Q9NPC3	Y2H Pooling	16189514
Intra	CCNB1IP1	Q9NPC3	KEAP1	Homo sapiens	Q14145	Y2H Array	25416956
Intra	CCNB1IP1	Q9NPC3	CCNB1IP1	Homo sapiens	Q9NPC3	Y2H Array	25416956
Intra	CCNB1IP1	Q9NPC3	KEAP1	Homo sapiens	Q14145	Validated Y2H	25416956
Intra	CCNB1IP1	Q9NPC3	KEAP1	Homo sapiens	Q14145	Y2H Prey Pooling	25416956
Cross	CCNB1IP1	Q9NPC3	ubiqp_xenla	Crosspus laevis	P62972	Pull Down	12612082

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02119	CCNB1IP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CCNB1IP1	VGNC	VGNC:70827
Bos taurus	CCNB1IP1	VGNC	VGNC:26959
Canis familiaris	CCNB1IP1	VGNC	VGNC:38894
Felis catus	CCNB1IP1	VGNC	VGNC:60552
Rattus norvegicus	CCNB1IP1	RGD	RGD:1561930
Mus musculus	CCNB1IP1	MGD	MGI:2685134

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