PTPRM - protein tyrosine phosphatase receptor type M Gene

Homo sapiens

Also known as RPTPM; RPTPU; PTPRL1; hR-PTPu; R-PTP-MU

Gene ID: 5797 | Gene type: protein coding

About PTPRM

Cytogenetic location: 18p11.23 Genomic coordinates (GRCh38): 18:7,567,316-8,406,856 (from NCBI)

This gene has 15 transcripts (splice variants), 283 orthologues and 35 paralogues. Broad expression in fat (RPKM 28.8), thyroid (RPKM 25.6) and 23 other tissues.

Summary

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms. [provided by RefSeq, Jul 2008]

PTPRM Products(8)

mRNA	Protein	Name
NM_001105244.2	NP_001098714.1	receptor-type tyrosine-protein phosphatase mu isoform 1 precursor
NM_001378142.1	NP_001365071.1	receptor-type tyrosine-protein phosphatase mu isoform 3
NM_001378143.1	NP_001365072.1	receptor-type tyrosine-protein phosphatase mu isoform 4
NM_001378144.1	NP_001365073.1	receptor-type tyrosine-protein phosphatase mu isoform 5
NM_001378145.1	NP_001365074.1	receptor-type tyrosine-protein phosphatase mu isoform 6
NM_001378146.1	NP_001365075.1	receptor-type tyrosine-protein phosphatase mu isoform 7
NM_001378147.1	NP_001365076.1	receptor-type tyrosine-protein phosphatase mu isoform 8
NM_002845.4	NP_002836.3	receptor-type tyrosine-protein phosphatase mu isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cadherin binding	IDA IDA: Inferred from direct assay	9531566	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	10809770	GOA
enables phosphatase activity	IDA IDA: Inferred from direct assay	10753936	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9531566	GOA
enables protein tyrosine phosphatase activity	IDA IDA: Inferred from direct assay	8393854	GOA
enables transmembrane receptor protein tyrosine phosphatase activity	IDA IDA: Inferred from direct assay	10809770	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in homophilic cell adhesion via plasma membrane adhesion molecules	IDA IDA: Inferred from direct assay	8393854	GOA
involved in negative regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	18566238	GOA
involved in negative regulation of endothelial cell migration	IMP IMP: Inferred from mutant phenotype	18566238	GOA
involved in negative regulation of endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	18566238	GOA
involved in neuron projection development	IDA IDA: Inferred from direct assay	16380380	GOA
involved in neuron projection development	IMP IMP: Inferred from mutant phenotype	17276081	GOA
involved in protein dephosphorylation	IDA IDA: Inferred from direct assay	8393854	GOA
involved in response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	18566238	GOA
involved in retina layer formation	IMP IMP: Inferred from mutant phenotype	14623235	GOA
involved in retinal ganglion cell axon guidance	IDA IDA: Inferred from direct assay	15080886	GOA
involved in signal transduction	IDA IDA: Inferred from direct assay	15080886	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in adherens junction	IDA IDA: Inferred from direct assay	17965016	GOA
is active in cell-cell junction	IDA IDA: Inferred from direct assay	10753936	GOA
located in cell-cell junction	IDA IDA: Inferred from direct assay	15491993	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	16380380	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	15706045	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	15491993	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTPRM Protein Structure

MAM

fn3

Y_phosphatase

0
300
600
900
1200
1452 a.a.

Protein Preferred Names

Protein Names

receptor-type tyrosine-protein phosphatase mu

protein tyrosine phosphatase mu

PTPRM Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PTPRM	P28827	PTPRM	Homo sapiens	P28827	Y2H	10809770
Intra	PTPRM	P28827	PTPRM	Homo sapiens	P28827	Anti Tag CoIP	10809770
Intra	PTPRM	P28827	H2BC5	Homo sapiens	P58876	Crosslink	30021884
Intra	PTPRM	P28827	H2BC21	Homo sapiens	Q16778	Crosslink	30021884
Intra	PTPRM	P28827	DTNBP1	Homo sapiens	Q96EV8	Anti Tag CoIP	27880917
Intra	PTPRM	P28827	NHSL1	Homo sapiens	Q5SYE7	BioID	27880917
Intra	PTPRM	P28827	nagA	Bacillus anthracis	A0A6L8NZ66	Y2H Pooling	20711500
Intra	PTPRM	P28827	EHD4	Homo sapiens	Q9H223	BioID	27880917
Intra	PTPRM	P28827	LMTK2	Homo sapiens	Q8IWU2	BioID	27880917
Intra	PTPRM	P28827	Cdh2	Mus musculus	P15116	CoIP	9531566
Cross	PTPRM	P28827	Cdh1	Mus musculus	P09803	CoIP	9531566
Intra	PTPRM	P28827	PTPRM	Homo sapiens	P28827	ToxCat	15978577
Intra	PTPRM	P28827	SELENBP1	Homo sapiens	Q13228	Anti Tag CoIP	33961781
Intra	PTPRM	P28827	Cdh4	Mus musculus	P39038	CoIP	9531566
Intra	PTPRM	P28827	CDC42BPA	Homo sapiens	Q5VT25	BioID	27880917

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Spastic Hemiplegia

Spastic Hemiplegic Cerebral Palsy	Hemiplegic Cerebral Palsy
Congenital Hemiplegia	Hemiplegic Infantile Cerebral Palsy
Cerebral Palsy Spastic Hemiplegic	Spastic Hemiplegia Cerebral Palsy
Hemiplegia, Spastic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11443	PTPRM Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PTPRM	VGNC	VGNC:76619
Felis catus	PTPRM	VGNC	VGNC:69177
Bos taurus	PTPRM	VGNC	VGNC:33553
Rattus norvegicus	PTPRM	RGD	RGD:620776
Mus musculus	PTPRM	MGD	MGI:102694
Canis familiaris	PTPRM	VGNC	VGNC:45192
Others	PTPRM	NCBI

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