SELENBP1 - selenium binding protein 1 Gene

Homo sapiens

Also known as MTO; LPSB; SP56; hSBP; EHMTO; SBP56; HEL-S-134P

Gene ID: 8991 | Gene type: protein coding

About SELENBP1

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:151,364,304-151,372,705 (from NCBI)

This gene has 19 transcripts (splice variants), 269 orthologues and is associated with 2 phenotypes. Broad expression in colon (RPKM 232.0), lung (RPKM 124.7) and 17 other tissues.

Summary

This gene encodes a member of the selenium-binding protein family. Selenium is an essential nutrient that exhibits potent anticarcinogenic properties, and deficiency of selenium may cause certain neurologic diseases. The effects of selenium in preventing Cancer and neurologic diseases may be mediated by selenium-binding proteins, and decreased expression of this gene may be associated with several types of Cancer. The encoded protein may play a selenium-dependent role in ubiquitination/deubiquitination-mediated protein degradation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]

SELENBP1 Products(3)

mRNA	Protein	Name
NM_001258288.2	NP_001245217.1	methanethiol oxidase isoform 2
NM_001258289.2	NP_001245218.1	methanethiol oxidase isoform 3
NM_003944.4	NP_003935.2	methanethiol oxidase isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables methanethiol oxidase activity	IMP IMP: Inferred from mutant phenotype	29255262	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SELENBP1 Protein Structure

SBP56

0
100
200
300
400
472 a.a.

Protein Preferred Names

Protein Names

methanethiol oxidase

56 kDa selenium-binding protein

Related Diseases

Diseases

Alias

Extraoral Halitosis Due To Methanethiol Oxidase Deficiency

Methanethiol Oxidase Deficiency	Extraoral Halitosis Due To Mto Deficiency
EHMTO	Mto Deficiency
Extraoral Halitosis With Dimethylsulfoxiduria	Autosomal Recessive Extra-Oral Halitosis
Mto-Deficiency

Methionine Adenosyltransferase Deficiency

Mat Deficiency	Hepatic Methionine Adenosyltransferase Deficiency
Deficiency Of Acetyl-Coa Acetyltransferase

Tyrosinemia

Hypertyrosinemia	Tyrosinemias
Hereditary Tyrosinemia	Hypertyrosinaemia
Tyrosinaemia	Hereditary Hypertyrosinemia

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12633	SELENBP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SELENBP1	VGNC	VGNC:64981
Bos taurus	SELENBP1	VGNC	VGNC:34422
Canis familiaris	SELENBP1	VGNC	VGNC:45981
Macaca mulatta	SELENBP1	VGNC	VGNC:100137
Rattus norvegicus	SELENBP1	RGD	RGD:620571
Mus musculus	SELENBP1	MGD	MGI:96825

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