2. Gene
  3. RRAGA - Ras related GTP binding A Gene

RRAGA - Ras related GTP binding A Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as FIP1; RAGA; FIP-1

Gene ID: 10670 | Gene type: protein coding

About RRAGA

Cytogenetic location: 9p22.1 Genomic coordinates (GRCh38): 9:19,049,427-19,051,025 (from NCBI)

This gene has 1 transcript (splice variant), 175 orthologues, 3 paralogues and is associated with 1 phenotype.

Summary

Enables several functions, including GTP binding activity; protein dimerization activity; and ubiquitin protein Ligase binding activity. Involved in several processes, including cellular response to amino acid starvation; negative regulation of autophagy; and positive regulation of TORC1 signaling. Located in lysosome and nucleus. Colocalizes with GATOR1 complex. [provided by Alliance of Genome Resources, Apr 2022]

RRAGA Products(1)

mRNA Protein Name
NM_006570.5 NP_006561.1 ras-related GTP-binding protein A
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables GTP binding IDA
IDA: Inferred from direct assay
7499430 GOA
enables GTPase activity IDA
IDA: Inferred from direct assay
31601708 GOA
enables phosphoprotein binding IDA
IDA: Inferred from direct assay
8995684 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
8995684 GOA
enables protein heterodimerization activity IPI
IPI: Inferred from physical interaction
11073942 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
14660641 GOA
enables protein-membrane adaptor activity IDA
IDA: Inferred from direct assay
31601708 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
25936802 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to amino acid starvation IMP
IMP: Inferred from mutant phenotype
25936802 GOA
involved in cellular response to amino acid stimulus IMP
IMP: Inferred from mutant phenotype
20381137 GOA
involved in cellular response to nutrient levels IDA
IDA: Inferred from direct assay
31601708 GOA
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
9394008 GOA
involved in negative regulation of autophagy IMP
IMP: Inferred from mutant phenotype
25936802 GOA
involved in positive regulation of TORC1 signaling IDA
IDA: Inferred from direct assay
31601708 GOA
involved in positive regulation of TORC1 signaling IMP
IMP: Inferred from mutant phenotype
25936802 GOA
involved in protein localization IMP
IMP: Inferred from mutant phenotype
20381137 GOA
involved in protein localization to lysosome IDA
IDA: Inferred from direct assay
31601708 GOA
involved in protein localization to membrane IDA
IDA: Inferred from direct assay
31601708 GOA
involved in tumor necrosis factor-mediated signaling pathway IDA
IDA: Inferred from direct assay
8995684 GOA
Cellular Component GO Annotation Evidence Reference Source
part of FNIP-folliculin RagC/D GAP IDA
IDA: Inferred from direct assay
36103527 GOA
part of GATOR1 complex IDA
IDA: Inferred from direct assay
25936802 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
9394008 GOA
is active in lysosomal membrane IDA
IDA: Inferred from direct assay
31601708 GOA
located in lysosome IDA
IDA: Inferred from direct assay
20381137 GOA
located in nucleoplasm IDA
IDA: Inferred from direct assay
8995684 GOA
located in nucleus IDA
IDA: Inferred from direct assay
9394008 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RRAGA Protein Structure

Gtr1_RagA

Gtr1_RagA: Gtr1/RagA G protein conserved region (9 - 235)

  • 0
  • 100
  • 200
  • 313 a.a.
Protein Preferred Names Protein Names

ras-related GTP-binding protein A

adenovirus E3 14.7 kDa-interacting protein 1

RRAGA Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
RRAGA Q7L523 DYNLT1 Homo sapiens P63172
Y2H Array
32296183
Intra
RRAGA Q7L523 DYNLT1 Homo sapiens P63172
Y2H Prey Pooling
32296183
Intra
RRAGA Q7L523 LAMTOR1 Homo sapiens Q6IAA8
Anti Bait CoIP
25561175
Intra
RRAGA Q7L523 LAMTOR1 Homo sapiens Q6IAA8
Anti Tag CoIP
25561175
Intra
RRAGA Q7L523 RRAGC Homo sapiens Q9HB90
BRET
37398436
Intra
RRAGA Q7L523 RRAGC Homo sapiens Q9HB90
Anti Tag CoIP
33961781
Intra
RRAGA Q7L523 RRAGC Homo sapiens Q9HB90
Y2H Pooling
16189514
Intra
RRAGA Q7L523 RRAGC Homo sapiens Q9HB90
Anti Tag CoIP
28514442
Intra
RRAGA Q7L523 RRAGC Homo sapiens Q9HB90
BiLC
37398436
Intra
RRAGA Q7L523 RRAGC Homo sapiens Q9HB90
Anti Tag CoIP
11073942
Intra
RRAGA Q7L523 RRAGC Homo sapiens Q9HB90
Y2H
11073942
Intra
RRAGA Q7L523 RRAGC Homo sapiens Q9HB90
Anti Tag CoIP
25561175
Intra
RRAGA Q7L523 RRAGC Homo sapiens Q9HB90
Lumier
37398436
Intra
RRAGA Q7L523 RRAGD Homo sapiens Q9NQL2
Anti Tag CoIP
25561175
Intra
RRAGA Q7L523 RRAGD Homo sapiens Q9NQL2
Anti Tag CoIP
11073942
Intra
RRAGA Q7L523 RRAGD Homo sapiens Q9NQL2
Anti Tag CoIP
28514442
Intra
RRAGA Q7L523 RRAGD Homo sapiens Q9NQL2
Anti Tag CoIP
33961781
Intra
RRAGA Q7L523 RRAGD Homo sapiens Q9NQL2
Y2H
11073942
Intra
RRAGA Q7L523 SLC38A9 Homo sapiens Q8NBW4
Anti Bait CoIP
32433612
Intra
RRAGA Q7L523 SLC38A9 Homo sapiens Q8NBW4
Anti Bait CoIP
25561175
Intra
RRAGA Q7L523 SLC38A9 Homo sapiens Q8NBW4
Anti Tag CoIP
25561175
Intra
RRAGA Q7L523 SLC38A9 Homo sapiens Q8NBW4
Anti Bait CoIP
25567906
Intra
RRAGA Q7L523 SLC38A9 Homo sapiens Q8NBW4
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Premature Ovarian Failure 18

POF18

Primary Ovarian Insufficiency 18

Ovarian Failure, Premature, Type 18
Birt-Hogg-Dube Syndrome

Hornstein-Knickenberg Syndrome

Fibrofolliculomas With Trichodiscomas And Acrochordons

BHD

Birt-Hogg-Dubé Syndrome

Multiple Fibrofolliculoma Familial

Bhd Syndrome

Birt Hogg Dube Syndrome

Hornstein-Birt-Hogg-Dubé Syndrome

Multiple Fibrofolliculomas
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12276 RRAGA Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RRAGA RGD RGD:619804
Macaca mulatta RRAGA VGNC VGNC:77031
Felis catus RRAGA VGNC VGNC:64767
Mus musculus RRAGA MGD MGI:1915691