2. Gene
  3. Trpm7 - transient receptor potential cation channel, subfamily M, member 7 Gene

Trpm7 - transient receptor potential cation channel, subfamily M, member 7 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as CHAK; CHAK1; Ltpr7; Ltrpc7; LTrpC-7; TRPPLIK; 2310022G15Rik; 4833414K03Rik; 5033407O22Rik

Gene ID: 58800 | Gene type: protein coding

About Trpm7

Summary

Enables Calcium Channel activity; cytoskeletal protein binding activity; and kinase activity. Acts upstream of or within several processes, including calcium ion transport; calcium-dependent cell-matrix adhesion; and protein autophosphorylation. Located in plasma membrane and ruffle. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and skin. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis-parkinsonism/dementia complex 1. Orthologous to human TRPM7 (transient receptor potential cation channel subfamily M member 7). [provided by Alliance of Genome Resources, Apr 2022]

Trpm7 Products(2)

mRNA Protein Name
NM_001164325.1 NP_001157797.1 transient receptor potential cation channel subfamily M member 7 isoform 2
NM_021450.2 NP_067425.2 transient receptor potential cation channel subfamily M member 7 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables actin binding IDA
IDA: Inferred from direct assay
16407977 MGI
enables calcium channel activity IDA
IDA: Inferred from direct assay
16407977 MGI
enables kinase activity IDA
IDA: Inferred from direct assay
16407977 MGI
enables myosin binding IPI
IPI: Inferred from physical interaction
16407977 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16407977 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
29203869 MGI
enables zinc ion transmembrane transporter activity IDA
IDA: Inferred from direct assay
28696294 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within actomyosin structure organization IDA
IDA: Inferred from direct assay
16407977 MGI
acts upstream of or within calcium ion transport IDA
IDA: Inferred from direct assay
16407977 MGI
acts upstream of or within calcium-dependent cell-matrix adhesion IDA
IDA: Inferred from direct assay
16407977 MGI
involved in intracellular magnesium ion homeostasis IMP
IMP: Inferred from mutant phenotype
21045827 MGI
involved in magnesium ion transmembrane transport IDA
IDA: Inferred from direct assay
11385574 MGI
acts upstream of or within protein autophosphorylation IDA
IDA: Inferred from direct assay
16407977 MGI
involved in protein homotetramerization IDA
IDA: Inferred from direct assay
30108148 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
16407977 MGI
involved in zinc ion transport IDA
IDA: Inferred from direct assay
28696294 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
28696294 MGI
located in nucleus IDA
IDA: Inferred from direct assay
24855944 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
16407977 MGI
located in ruffle IDA
IDA: Inferred from direct assay
16407977 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transient receptor potential cation channel subfamily M member 7

channel-kinase 1

long transient receptor potential channel 7

transient receptor potential M7

transient receptor potential-phospholipase C-interacting kinase

transient receptor potential-related protein, ChaK

Trpm7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Trpm7 Q923J1 Ddb1 Mus musculus Q3U1J4
Anti Tag CoIP
24855944
Cross
Trpm7 Q923J1 DDX3X Homo sapiens O00571
Anti Bait CoIP
24855944
Intra
Trpm7 Q923J1 Actb Mus musculus P60710
Anti Tag CoIP
16407977
Intra
Trpm7 Q923J1 Actb Mus musculus P60710
Anti Tag CoIP
24855944
Intra
Trpm7 Q923J1 Myh9 Mus musculus Q8VDD5
Anti Tag CoIP
16407977
Intra
Trpm7 Q923J1 Myh9 Mus musculus Q8VDD5
Protein Kinase Assay
16407977
Intra
Trpm7 Q923J1 Myh9 Mus musculus Q8VDD5
Anti Tag CoIP
24855944
Cross
Trpm7 Q923J1 RYBP Homo sapiens Q8N488
Pull Down
24855944
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-101302 Naltriben mesylate 99.65% Unkown
HY-157227 VPC01091.4 Inhibitor 98.04% Unkown
HY-RS15117 TRPM7 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-133717 Naltriben / Unkown
HY-149999 Xeniafaraunol A Inhibitor / Unkown
HY-160509 BTB 06061 Inhibitor / Unkown
HY-162968 MRTF-A-IN-1 Inhibitor / Unkown
HY-162969 MRTF-A-IN-2 Inhibitor / Unkown
HY-168471 AAL-149 Inhibitor / Unkown
HY-168608 TRPM7-IN-1 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Trpm7 NCBI NCBI:54822