2. Gene
  3. RARG - retinoic acid receptor gamma Gene

RARG - retinoic acid receptor gamma Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as RARC; NR1B3; RARgamma

Gene ID: 5916 | Gene type: protein coding

About RARG

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:53,210,569-53,232,209 (from NCBI)

This gene has 18 transcripts (splice variants), 449 orthologues and 18 paralogues. Broad expression in skin (RPKM 47.1), esophagus (RPKM 32.0) and 18 other tissues.

Summary

This gene encodes a retinoic acid receptor that belongs to the nuclear hormone receptor family. Retinoic acid receptors (RARs) act as ligand-dependent transcriptional regulators. When bound to ligands, RARs activate transcription by binding as heterodimers to the retinoic acid response elements (RARE) found in the promoter regions of the target genes. In their unbound form, RARs repress transcription of their target genes. RARs are involved in various biological processes, including limb bud development, skeletal growth, and matrix homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

RARG Products(5)

mRNA Protein Name
NM_000966.6 NP_000957.1 retinoic acid receptor gamma isoform 1
NM_001042728.3 NP_001036193.1 retinoic acid receptor gamma isoform 2
NM_001243730.2 NP_001230659.1 retinoic acid receptor gamma isoform 4
NM_001243731.2 NP_001230660.1 retinoic acid receptor gamma isoform 5
NM_001243732.2 NP_001230661.1 retinoic acid receptor gamma isoform 3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
10428834 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence Reference Source
involved in response to retinoic acid IDA
IDA: Inferred from direct assay
17943189 GOA
involved in retinoic acid receptor signaling pathway IDA
IDA: Inferred from direct assay
17943189 GOA
Cellular Component GO Annotation Evidence Reference Source
located in chromatin IDA
IDA: Inferred from direct assay
21131358 GOA
located in nucleus IDA
IDA: Inferred from direct assay
18845237 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RARG Protein Structure

zf-C4

zf-C4: Zinc finger, C4 type (two domains) (89 - 157)

Hormone_recep

Hormone_recep: Ligand-binding domain of nuclear hormone receptor (227 - 395)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 454 a.a.
Protein Preferred Names Protein Names

retinoic acid receptor gamma

RAR-gamma

RARG Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
RARG P13631 SORBS3 Homo sapiens O60504-2
Anti Bait CoIP
15734736
Intra
RARG P13631 MYF5 Homo sapiens P13349
Y2H Array
32296183
Intra
RARG P13631 MYF5 Homo sapiens P13349
Y2H Prey Pooling
32296183
Intra
RARG P13631 BBS4 Homo sapiens Q96RK4
Y2H Prey Pooling
32296183
Intra
RARG P13631 BBS4 Homo sapiens Q96RK4
Validated Y2H
32296183
Intra
RARG P13631 BBS4 Homo sapiens Q96RK4
Y2H Array
32296183
Intra
RARG P13631 PRKAR1B Homo sapiens P31321
Y2H Array
32296183
Intra
RARG P13631 PRKAR1B Homo sapiens P31321
Validated Y2H
32296183
Intra
RARG P13631 PRKAR1B Homo sapiens P31321
Y2H Prey Pooling
32296183
Intra
RARG P13631 RXRG Homo sapiens P48443
Validated Y2H
32296183
Intra
RARG P13631 RXRB Homo sapiens P28702
Anti Tag CoIP
33961781
Intra
RARG P13631 RXRB Homo sapiens P28702
Anti Tag CoIP
28514442
Intra
RARG P13631 RXRB Homo sapiens P28702
Validated Y2H
32296183
Intra
RARG P13631 RXRB Homo sapiens P28702
Y2H Prey Pooling
32296183
Intra
RARG P13631 RXRB Homo sapiens P28702
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

RARG Antibodies

Cat. No. Product Name Application Reactivity
HY-P82115 Retinoic Acid Receptor gamma Antibody (YA1860) WB, ICC/IF Human, Rat

Related Diseases

Diseases Alias
Embryonal Carcinoma

Embryonal Neoplasm

Embryonal Cancer

Primary Extragonadal Embryonal Carcinoma

Embryo Neoplasm

Carcinoma Embryonal

Cancer Embryonal

Carcinoma, Embryonal

Extragonadal Embryonal Carcinoma

Cancer, Embryonal
Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic

Acute Myeloblastic Leukemia Type 3

Aml M3

APL

Leukemia, Acute Promyelocytic, Somatic

Aml With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Apml

Acute Myeloblastic Leukemia 3

Acute Myeloid Leukemia With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Acute Myeloblastic Leukaemia Type 3

Acute Myeloid Leukaemia M3

Acute Myeloid Leukemia M3

Acute Promyelocytic Leukaemia

M3 Anll

Myeloid Leukemia, Acute, M3

Leukemia Promyelocytic Acute

Leukemia, Promyelocytic, Acute

Leukemia, Acute, Promyelocytic
Fibrodysplasia Ossificans Progressiva

Myositis Ossificans Progressiva

Progressive Myositis Ossificans

FOP

Progressive Ossifying Myositis

Myositis Ossificans

Stone Man Syndrome

Man Of Stone

Myositis Ossificans Progressive

Diffuse Progressive Ossifying Polymyositis

Fibrodysplasia Ossificans Congenita

Myositis Ossificans Progressiva, Site Unspecified

Münchmeyer Disease

Fop - [Fibrodysplasia Ossificans Progressiva]

Progressive Myositis Ossificans Calcification
Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-155108B OATD-02 hydrochloride Inhibitor 99.88% Unkown
HY-155108 OATD-02 Inhibitor / Unkown
HY-RS11673 RARG Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus RARG VGNC VGNC:33730
Felis catus RARG VGNC VGNC:69242
Canis familiaris RARG VGNC VGNC:45353
Macaca mulatta RARG VGNC VGNC:76664
Rattus norvegicus RARG RGD RGD:1583230
Mus musculus RARG MGD MGI:97858