2. Immunology/Inflammation Metabolic Enzyme/Protease
  3. Arginase
  4. OATD-02 hydrochloride

OATD-02 hydrochloride is the hydrochloride salt form of OATD-02 (HY-155108). OATD-02 hydrochloride an orally active, competitive, reversible, noncovalent dual inhibitor of Arginase1 and Arginase2. OATD-02 hydrochloride is a slow offset inhibitor, blocking intracellular arginases with IC50s of 20 nM (hARG1), 39 nM (hARG2), 39 nM (mARG1), and 28 nM (rARG1), respectively. OATD-02 hydrochloride bolishes tumor immunosuppression induced by both arginases. OATD-02 hydrochloride can be used for melanoma study.

For research use only. We do not sell to patients.

OATD-02 hydrochloride Chemical Structure

OATD-02 hydrochloride Chemical Structure

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1 mg USD 630 In-stock
5 mg USD 1575 In-stock
10 mg USD 2520 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of OATD-02 hydrochloride:

OATD-02 hydrochloride Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE OATD-02 hydrochloride

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  • Purity & Documentation

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  • Customer Review

Description

OATD-02 hydrochloride is the hydrochloride salt form of OATD-02 (HY-155108). OATD-02 hydrochloride an orally active, competitive, reversible, noncovalent dual inhibitor of Arginase1 and Arginase2. OATD-02 hydrochloride is a slow offset inhibitor, blocking intracellular arginases with IC50s of 20 nM (hARG1), 39 nM (hARG2), 39 nM (mARG1), and 28 nM (rARG1), respectively. OATD-02 hydrochloride bolishes tumor immunosuppression induced by both arginases. OATD-02 hydrochloride can be used for melanoma study[1].

IC50 & Target

IC50: 20 nM (hARG1), 39 nM (hARG2), 39 nM (mARG1), 28 nM (rARG1)
Molecular Weight

308.61

Formula

C12H26BClN2O4
Appearance

Solid

Color

White to off-white

SMILES

N[C@]1(C(O)=O)C[C@H](CCB(O)O)CC[C@H]1CN(C)C.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 250 mg/mL (810.08 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2403 mL 16.2017 mL 32.4034 mL
5 mM 0.6481 mL 3.2403 mL 6.4807 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.2403 mL 16.2017 mL 32.4034 mL 81.0084 mL
5 mM 0.6481 mL 3.2403 mL 6.4807 mL 16.2017 mL
10 mM 0.3240 mL 1.6202 mL 3.2403 mL 8.1008 mL
15 mM 0.2160 mL 1.0801 mL 2.1602 mL 5.4006 mL
20 mM 0.1620 mL 0.8101 mL 1.6202 mL 4.0504 mL
25 mM 0.1296 mL 0.6481 mL 1.2961 mL 3.2403 mL
30 mM 0.1080 mL 0.5401 mL 1.0801 mL 2.7003 mL
40 mM 0.0810 mL 0.4050 mL 0.8101 mL 2.0252 mL
50 mM 0.0648 mL 0.3240 mL 0.6481 mL 1.6202 mL
60 mM 0.0540 mL 0.2700 mL 0.5401 mL 1.3501 mL
80 mM 0.0405 mL 0.2025 mL 0.4050 mL 1.0126 mL
100 mM 0.0324 mL 0.1620 mL 0.3240 mL 0.8101 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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OATD-02 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OATD-02OATD02OATD 02ArginaseBMDMHuman primary hepatocytesB16F10ImmunosuppressionMelanomaorally activecompetitivereversibleInhibitorinhibitorinhibit

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