2. Gene
  3. RXRG - retinoid X receptor gamma Gene

RXRG - retinoid X receptor gamma Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as RXRC; NR2B3; RXRgamma; RXR-gamma

Gene ID: 6258 | Gene type: protein coding

About RXRG

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:165,400,922-165,445,126 (from NCBI)

This gene has 4 transcripts (splice variants), 277 orthologues and 11 paralogues. Broad expression in heart (RPKM 1.5), adrenal (RPKM 1.5) and 22 other tissues.

Summary

This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung Cancer cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]

RXRG Products(4)

mRNA Protein Name
NR_033824.2
NM_001256571.2 NP_001243500.1 retinoic acid receptor RXR-gamma isoform c
NM_001256570.2 NP_001243499.1 retinoic acid receptor RXR-gamma isoform c
NM_006917.5 NP_008848.1 retinoic acid receptor RXR-gamma isoform a
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables molecular condensate scaffold activity IDA
IDA: Inferred from direct assay
31881311 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RXRG Protein Structure

Nuc_recep-AF1

Nuc_recep-AF1: Nuclear/hormone receptor activator site AF-1 (24 - 134)

zf-C4

zf-C4: Zinc finger, C4 type (two domains) (138 - 206)

Hormone_recep

Hormone_recep: Ligand-binding domain of nuclear hormone receptor (261 - 443)

  • 0
  • 100
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  • 400
  • 463 a.a.
Protein Preferred Names Protein Names

retinoic acid receptor RXR-gamma

nuclear receptor subfamily 2 group B member 3

RXRG Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
RXRG P48443 NR1H2 Homo sapiens F1D8P7
Validated Y2H
25416956
Intra
RXRG P48443 NR1H2 Homo sapiens F1D8P7
Y2H Prey Pooling
32296183
Intra
RXRG P48443 NR1H2 Homo sapiens F1D8P7
Validated Y2H
25910212
Intra
RXRG P48443 NR1H2 Homo sapiens F1D8P7
Y2H Prey Pooling
25416956
Intra
RXRG P48443 NR1H2 Homo sapiens F1D8P7
Y2H Array
25416956
Intra
RXRG P48443 NR1H2 Homo sapiens F1D8P7
Y2H Array
25910212
Intra
RXRG P48443 NR1H2 Homo sapiens F1D8P7
Y2H Array
32296183
Intra
RXRG P48443 NR1H2 Homo sapiens F1D8P7
Y2H Bait-Prey Pool
25910212
Intra
RXRG P48443 RARA Homo sapiens P10276-2
Validated Y2H
25910212
Intra
RXRG P48443 RARA Homo sapiens P10276-2
Y2H Bait-Prey Pool
25910212
Intra
RXRG P48443 RARA Homo sapiens P10276-2
Y2H Array
25910212
Intra
RXRG P48443 RARA Homo sapiens P10276-2
Validated Y2H
25416956
Intra
RXRG P48443 RARA Homo sapiens P10276-2
Y2H Prey Pooling
25416956
Intra
RXRG P48443 CKMT1A Homo sapiens P12532
Y2H Prey Pooling
32296183
Intra
RXRG P48443 CKMT1A Homo sapiens P12532
Y2H Array
32296183
Intra
RXRG P48443 NR1H3 Homo sapiens Q13133-3
Validated Y2H
25910212
Intra
RXRG P48443 NR1H3 Homo sapiens Q13133-3
Y2H Array
25910212
Intra
RXRG P48443 NR1H3 Homo sapiens Q13133-3
Y2H Prey Pooling
32296183
Intra
RXRG P48443 NR1H3 Homo sapiens Q13133-3
Validated Y2H
32296183
Intra
RXRG P48443 NR1H3 Homo sapiens Q13133-3
Y2H Array
32296183
Intra
RXRG P48443 NR1H3 Homo sapiens Q13133-3
Y2H Bait-Prey Pool
25910212
Intra
RXRG P48443 NR1H4 Homo sapiens Q96RI1-1
Validated Y2H
32296183
Intra
RXRG P48443 NR1H4 Homo sapiens Q96RI1-1
Y2H Array
32296183
Intra
RXRG P48443 NR1H4 Homo sapiens Q96RI1-1
Y2H Prey Pooling
32296183
Intra
RXRG P48443 VDR Homo sapiens P11473-2
MAPPIT
32296183
Intra
RXRG P48443 VDR Homo sapiens P11473-2
Y2H Prey Pooling
32296183
Intra
RXRG P48443 VDR Homo sapiens P11473-2
Y2H Array
32296183
Intra
RXRG P48443 MPPED2 Homo sapiens Q15777
Validated Y2H
32296183
Intra
RXRG P48443 MPPED2 Homo sapiens Q15777
Y2H Prey Pooling
25416956
Intra
RXRG P48443 RARG Homo sapiens P13631
Y2H Prey Pooling
32296183
Intra
RXRG P48443 RARG Homo sapiens P13631
Y2H Array
32296183
Intra
RXRG P48443 GIPC1 Homo sapiens O14908-2
Y2H Pooling
32814053
Intra
RXRG P48443 GIPC1 Homo sapiens O14908-2
Validated Y2H
32814053
Intra
RXRG P48443 GIPC1 Homo sapiens O14908-2
Y2H Array
32814053
Intra
RXRG P48443 RARA Homo sapiens P10276
Y2H Array
31515488
Intra
RXRG P48443 RARA Homo sapiens P10276
Y2H Prey Pooling
25416956
Intra
RXRG P48443 RARA Homo sapiens P10276
Validated Y2H
25416956
Intra
RXRG P48443 RARA Homo sapiens P10276
Y2H Array
25416956
Intra
RXRG P48443 RARA Homo sapiens P10276
Y2H Array
29892012
Intra
RXRG P48443 RARA Homo sapiens P10276
Y2H
21988832
Intra
RXRG P48443 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
RXRG P48443 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
RXRG P48443 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
RXRG P48443 NR1H2 Homo sapiens P55055
Y2H Array
20211142
Intra
RXRG P48443 NR1H2 Homo sapiens P55055
Anti Tag CoIP
33961781
Intra
RXRG P48443 NR1H2 Homo sapiens P55055
Anti Tag CoIP
28514442
Intra
RXRG P48443 NR1H3 Homo sapiens Q13133
Y2H Array
25416956
Intra
RXRG P48443 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra
RXRG P48443 RARB Homo sapiens P10826-2
Validated Y2H
25416956
Intra
RXRG P48443 RARB Homo sapiens P10826-2
Y2H Array
31515488
Intra
RXRG P48443 RARB Homo sapiens P10826-2
Y2H Prey Pooling
32296183
Intra
RXRG P48443 RARB Homo sapiens P10826-2
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hyperlipidemia, Familial Combined, 3

Familial Combined Hyperlipidemia

Combined Hyperlipidemia, Familial

Mixed Hyperlipidaemia

FCHL3

Hyperlipidemia, Familial Combined

Familial Multiple Lipoprotein-Type Hyperlipidemia

Hyperbetalipoproteinemia With Prebetalipoproteinemia

Type Iib Hyperlipoproteinemia

Hyperlipidemia Familial Combined

Hyperlipoproteinemia Type Iib

Mixed Hyperlipemia

Hyperlipidaemia, Group C

Familial Hypercholesterolaemia With Hyperlipaemia

Familial Hyperbetalipoproteinaemia And Hyperprebetalipoproteinaemia

Hyperbetalipoproteinaemia With Prebetalipoproteinaemia

Hypercholesterolaemia With Endogenous Hyperglyceridaemia

Prebetalipoproteinemia Hyperbetalipoproteinaemia

Remnant Hyperlipoproteinemia
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Protection Against

Lung Cancer, Susceptibility To

Adenocarcinoma Of Lung, Somatic

Nonsmall Cell Lung Cancer

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Cone-Rod Dystrophy 2

Cone-Rod Dystrophy

CORD2

Cone-Rod Retinal Dystrophy

Rcrd2

Cone-Rod Retinal Dystrophy 2

Crd2

Cord

Crd

Retinal Cone-Rod Dystrophy

Cone-Rod Retinal Dystrophy-2

Retinal Cone-Rod Dystrophy 2

Tapetoretinal Degeneration

Cone-Rod Degeneration

Cone Rod Dystrophy

Dystrophy, Cone-Rod

Dystrophy, Cone-Rod, Type 2

Retinitis Pigmentosa

Retinitis Pigmentosa 2

Progressive Cone-Rod Dystrophy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12363 RXRG Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS12364 Rxrg Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS12365 RXRG Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-160212 JP3000 Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris RXRG VGNC VGNC:45819
Mus musculus RXRG MGD MGI:98216
Macaca mulatta RXRG VGNC VGNC:76953
Rattus norvegicus RXRG RGD RGD:620046
Felis catus RXRG VGNC VGNC:64835
Bos taurus RXRG VGNC VGNC:34232