RXRB - retinoid X receptor beta Gene

Homo sapiens

Also known as NR2B2; DAUDI6; RCoR-1; RXRbeta; H-2RIIBP; RXR-beta

Gene ID: 6257 | Gene type: protein coding

About RXRB

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:33,193,588-33,200,853 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 215 orthologues and 11 paralogues. Ubiquitous expression in thyroid (RPKM 13.3), spleen (RPKM 12.9) and 25 other tissues.

Summary

This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). The encoded protein forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

RXRB Products(3)

mRNA	Protein	Name
NM_001270401.2	NP_001257330.1	retinoic acid receptor RXR-beta isoform 1
NM_001291989.2	NP_001278918.1	retinoic acid receptor RXR-beta isoform 3
NM_021976.5	NP_068811.1	retinoic acid receptor RXR-beta isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	12767074	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12767074	GOA
enables nuclear receptor activity	IDA IDA: Inferred from direct assay	1662118	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	1662118	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12767074	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of RNA polymerase II transcription regulator complex	IPI IPI: Inferred from physical interaction	25416956	GOA
located in nucleus	IDA IDA: Inferred from direct assay	7990953	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RXRB Protein Structure

zf-C4

Hormone_recep

0
100
200
300
400
500
533 a.a.

Protein Preferred Names

Protein Names

retinoic acid receptor RXR-beta

MHC class I promoter binding protein

Related Diseases

Diseases

Alias

Granulomatosis With Polyangiitis

GPA	Wegener Granulomatosis
Wegener Granulomatosis, Formerly	Midline Granulomatosis
Wg, Formerly	Necrotizing Respiratory Granulomatosis
Wg	Wegeners Granulomatosis
Pauci-Immune Glomerulonephritis Associated With Granulomatosis With Polyangiitis

Vasculitis

Angiitis	Autoimmune Vasculitis
Systemic Vasculitis	Vasculitis, Autoimmune

Otospondylomegaepiphyseal Dysplasia, Autosomal Dominant

Weissenbacher-Zweymuller Syndrome	Wzs
Pierre Robin Syndrome With Fetal Chondrodysplasia	OSMEDA
Weissenbacher-Zweymüller Syndrome	Heterozygous Osmed
Stickler Syndrome, Type 3	Osmed, Heterozygous
Pierre Robin Syndrome With Fetal Chondrodysplasia Stickler Syndrome, Nonocular Type, Formerly	Stickler Syndrome, Type Iii, Formerly
Stl3, Formerly	Piere-Robin Syndrome
Pierre Robin Malformation	Heterozygous Otospondylomegaepiphyseal Dysplasia
Autosomal Dominant Otospondylomegaepiphyseal Dysplasia	Ad Osmed
Stickler Syndrome Type 3	Stickler Syndrome, Non-Ocular Type
Stickler-Like Syndrome	Stickler Syndrome 3
Stickler Syndrome Non-Ocular Type	Stickler Syndrome Type Iii
Stl3	Weissenbacher-Zweymueller Syndrome
Stickler Syndrome, Type Iii	Pierre Robin Syndrome
Dysplasia, Otospondylomegaepiphyseal, Autosomal Dominant

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Endometrial Cancer

Endometrial Carcinoma	Endometrial Neoplasm
Malignant Neoplasm Of Endometrium	Endometrioid Carcinoma
Endometrial Neoplasms	Carcinoma, Endometrioid
Endometrial Cancer, Familial	Endometrial Carcinoma, Somatic
Endometrial Cancer, Susceptibility To	Endometrial Ca
Malignant Endometrial Neoplasm	Neoplasm Of Endometrium
Primary Malignant Neoplasm Of Endometrium	Tumor Of Endometrium
Carcinoma Of The Endometrium	Endometrioid Carcinoma Of Female Reproductive System
ENDMC	Carcinoma Endometrioid
Endometrial Cancers	Cancer, Endometrial
Uterine Corpus Cancer

Alcohol Dependence

Alcoholism	Alcohol Dependence, Susceptibility To
Alcohol Dependence, Protection Against	Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against
Alcoholism, Susceptibility To	Alcoholic Intoxication, Chronic
Pharyngeal Neoplasms	Chronic Alcoholism
Dipsomania	Alcohol Addiction
Ethanol Dependence	Chronic Ethanolism
Chronic Alcoholic Disease Nos	Alcoholic Disease Nos
Alcoholic

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12362	RXRB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-160212	JP3000	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RXRB	VGNC	VGNC:45818
Macaca mulatta	RXRB	VGNC	VGNC:76952
Mus musculus	RXRB	MGD	MGI:98215
Bos taurus	RXRB	VGNC	VGNC:34231
Rattus norvegicus	RXRB	RGD	RGD:3611
Others	RXRB	NCBI

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