RFC3 - replication factor C subunit 3 Gene

Homo sapiens

Also known as RFC38

Gene ID: 5983 | Gene type: protein coding

About RFC3

Cytogenetic location: 13q13.2 Genomic coordinates (GRCh38): 13:33,818,149-33,977,377 (from NCBI)

This gene has 3 transcripts (splice variants), 208 orthologues and 3 paralogues. Ubiquitous expression in lymph node (RPKM 1.9), bone marrow (RPKM 1.4) and 24 other tissues.

Summary

The elongation of primed DNA templates by DNA Polymerase delta and DNA Polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kDa. This gene encodes the 38 kDa subunit. This subunit is essential for the interaction between the 140 kDa subunit and the core complex that consists of the 36, 37, and 40 kDa subunits. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

RFC3 Products(2)

mRNA	Protein	Name
NM_002915.4	NP_002906.1	replication factor C subunit 3 isoform 1
NM_181558.3	NP_853536.2	replication factor C subunit 3 isoform 2

RFC3 Protein Structure

DNA_pol3_delta2

Rep_fac_C

0
100
200
300
356 a.a.

Protein Preferred Names

Protein Names

replication factor C subunit 3

A1 38 kDa subunit

RFC3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RFC3	P40938	ANKRD40	Homo sapiens	Q6AI12	Y2H Prey Pooling	32296183
Intra	RFC3	P40938	ANKRD40	Homo sapiens	Q6AI12	Y2H Array	32296183
Intra	RFC3	P40938	ANKRD40	Homo sapiens	Q6AI12	Validated Y2H	32296183
Intra	RFC3	P40938	RFC4	Homo sapiens	P35249	Y2H Prey Pooling	32296183
Intra	RFC3	P40938	RFC4	Homo sapiens	P35249	Pull Down	9488738
Intra	RFC3	P40938	RFC4	Homo sapiens	P35249	Y2H Array	32296183
Intra	RFC3	P40938	INCA1	Homo sapiens	Q0VD86	Validated Y2H	32296183
Intra	RFC3	P40938	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	RFC3	P40938	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183
Intra	RFC3	P40938	KHDRBS3	Homo sapiens	O75525	Y2H Prey Pooling	32296183
Intra	RFC3	P40938	KHDRBS3	Homo sapiens	O75525	Y2H Array	32296183
Intra	RFC3	P40938	KHDRBS2	Homo sapiens	Q5VWX1	Y2H Array	32296183
Intra	RFC3	P40938	KHDRBS2	Homo sapiens	Q5VWX1	Y2H Prey Pooling	32296183
Intra	RFC3	P40938	KHDRBS2	Homo sapiens	Q5VWX1	Validated Y2H	32296183
Intra	RFC3	P40938	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	RFC3	P40938	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	RFC3	P40938	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Childhood Apraxia Of Speech

Cas	Articulatory Apraxia
Das	Developmental Apraxia Of Speech
Developmental Verbal Apraxia	Developmental Verbal Dyspraxia
Speech And Language Disorder With Orofacial Dyspraxia	Articulation Disorders, Developmental
Apraxia, Articulatory	Apraxia, Developmental Verbal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11867	RFC3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RFC3	RGD	RGD:1306832
Macaca mulatta	RFC3	VGNC	VGNC:76902
Felis catus	RFC3	VGNC	VGNC:69296
Bos taurus	RFC3	VGNC	VGNC:33887
Canis familiaris	RFC3	VGNC	VGNC:45494
Mus musculus	RFC3	MGD	MGI:1916513

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